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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sfxJANUncharacterized protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3sfxJANUncharacterized protein/1.000
3sfy3FYUncharacterized protein/0.722
3q7fED2Uncharacterized protein/0.709
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.578
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.571
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.559
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.556
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.550
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.548
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.548
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.547
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.547
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.544
1s63778Protein farnesyltransferase subunit beta2.5.1.580.544
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.542
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.541
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.535
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.534
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.534
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.534
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.533
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.533
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.531
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.526
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.524
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.521
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.521
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.520
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.520
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.514
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.509
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.503
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.499
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.497
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.494
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.485
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.471
2xugTZ4Acetylcholinesterase3.1.1.70.462
4zj8SUVOrexin receptor type 1/0.460
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.459
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.458
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.457
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.455
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.447
2jf0HBPAcetylcholinesterase3.1.1.70.445
4mbsMRVC-C chemokine receptor type 5/0.445
1t7o152Carnitine O-acetyltransferase2.3.1.70.444
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.444
1pt5ACOFormyl-CoA:oxalate CoA-transferase/0.443
1x1bSAHC-20 methyltransferase/0.443
5jqhCAUBeta-2 adrenergic receptor/0.443
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.440