sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.786 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.783 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.780 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.752 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.741 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.733 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.720 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.720 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.719 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.719 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.715 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.714 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.713 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.712 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.710 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.705 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.704 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.695 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.688 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.687 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.685 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.677 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.676 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.674 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.666 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.658 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.650 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.638 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.602 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.577 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.569 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.568 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.564 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.564 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.562 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.558 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.551 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.548 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.542 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.531 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.519 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.519 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.518 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.517 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.512 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.502 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.495 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.493 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.490 | |
| 4iah | 1DX | Alr2278 protein | / | 0.489 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.488 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.487 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.486 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.481 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.480 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.477 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.476 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.476 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.476 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.475 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.475 | |
| 4iae | 1DX | Alr2278 protein | / | 0.475 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.474 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4nvk | 2NY | Peroxidase | / | 0.471 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.469 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.469 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.468 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.467 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.467 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.467 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.466 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.464 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.463 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.463 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.463 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.462 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.462 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.462 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.461 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.461 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.461 | |
| 1fml | RTL | Retinol dehydratase | / | 0.460 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.460 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.459 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.459 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.459 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.459 | |
| 3eku | CY9 | Actin-5C | / | 0.459 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.458 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.458 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.458 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.458 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.457 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.457 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.457 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.457 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.457 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.457 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.456 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.456 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.456 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 5cho | FAD | Flavin reductase | / | 0.456 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.455 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.455 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.455 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.455 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.455 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.454 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.454 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4iaw | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.454 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.454 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.453 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.453 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.453 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.453 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.452 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.452 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.452 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.452 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.451 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.451 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.451 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.450 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.450 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.450 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.450 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.450 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.449 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.449 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.449 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.449 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.448 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.448 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.448 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.448 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.448 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.448 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.448 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.448 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.447 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.447 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.447 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.447 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 3v2u | ATP | Protein GAL3 | / | 0.447 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.447 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.447 | |
| 4n1g | CEI | Obelin | / | 0.447 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.446 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.446 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.446 | |
| 4jic | FMN | GTN Reductase | / | 0.446 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.446 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.445 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.445 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.445 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.445 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.445 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1oo5 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.444 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.444 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.444 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.444 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.443 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.443 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.443 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.443 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.443 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.443 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.442 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.442 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1qxo | FMN | Chorismate synthase | / | 0.441 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.441 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.441 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.441 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.441 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.441 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.441 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.441 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.441 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.440 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.440 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.440 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.440 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.440 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.440 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.440 | |
| 4rel | KMP | Glycosyltransferase | / | 0.440 |