sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3s7a	684	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3s7a	684	Dihydrofolate reductase	1.5.1.3	1.000
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.536
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.507
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.503
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.500
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.500
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.492
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.482
3nxx	NDP	Dihydrofolate reductase	1.5.1.3	0.482
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.482
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.476
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.462
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.459
2w3b	NDP	Dihydrofolate reductase	1.5.1.3	0.449
1dr3	TAP	Dihydrofolate reductase	1.5.1.3	0.446
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.442
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.440