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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s4qNK0Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3s4qNK0Mitogen-activated protein kinase 14/1.000
1zyjBI5Mitogen-activated protein kinase 14/0.593
3fklFKLMitogen-activated protein kinase 14/0.582
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.569
3gfeP37Mitogen-activated protein kinase 14/0.549
3uvqFS8Mitogen-activated protein kinase 14/0.548
3mpt1GKMitogen-activated protein kinase 14/0.541
3mvl38PMitogen-activated protein kinase 14/0.538
4kiq1RAMitogen-activated protein kinase 14/0.538
3hl7I47Mitogen-activated protein kinase 14/0.537
3iphG11Mitogen-activated protein kinase 14/0.537
4nka2K7Fibroblast growth factor receptor 1/0.537
3hllI45Mitogen-activated protein kinase 14/0.536
4f640S8Fibroblast growth factor receptor 1/0.530
1ywrLI9Mitogen-activated protein kinase 14/0.529
2balPQAMitogen-activated protein kinase 14/0.528
3nww3NWMitogen-activated protein kinase 14/0.528
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.527
3fln3FNMitogen-activated protein kinase 14/0.525
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.523
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.522
4kip1R9Mitogen-activated protein kinase 14/0.521
3l8xN4DMitogen-activated protein kinase 14/0.518
3flyFLYMitogen-activated protein kinase 14/0.517
3hp552PMitogen-activated protein kinase 14/0.516
4aa4QC0Mitogen-activated protein kinase 14/0.516
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.513
4eh60ONMitogen-activated protein kinase 14/0.513
3u8w09JMitogen-activated protein kinase 14/0.512
2rg5279Mitogen-activated protein kinase 14/0.511
3gc9B45Mitogen-activated protein kinase 112.7.11.240.511
4lopSB4Mitogen-activated protein kinase 14/0.511
3dt1P40Mitogen-activated protein kinase 14/0.509
3uvp048Mitogen-activated protein kinase 14/0.509
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.507
4f630S7Fibroblast growth factor receptor 1/0.507
4nks2M2Fibroblast growth factor receptor 1/0.507
2rg6287Mitogen-activated protein kinase 14/0.505
3fi4FI4Mitogen-activated protein kinase 14/0.505
3fskRO6Mitogen-activated protein kinase 14/0.505
3itzP66Mitogen-activated protein kinase 14/0.505
2zb0GK3Mitogen-activated protein kinase 14/0.504
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.503
3flsFLSMitogen-activated protein kinase 14/0.503
4aa5NQBMitogen-activated protein kinase 14/0.503
3roc29AMitogen-activated protein kinase 14/0.500
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.499
3mpaSB2Mitogen-activated protein kinase 14/0.498
4kin1M8Mitogen-activated protein kinase 14/0.498
4y93746Tyrosine-protein kinase/0.498
2zb1GK4Mitogen-activated protein kinase 14/0.496
3flwFLWMitogen-activated protein kinase 14/0.495
3fmh533Mitogen-activated protein kinase 14/0.494
4nk92K5Fibroblast growth factor receptor 1/0.492
1oecAA2Fibroblast growth factor receptor 2/0.491
1ouk084Mitogen-activated protein kinase 14/0.491
4anqVGHALK tyrosine kinase receptor2.7.10.10.491
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3gubGUBDeath-associated protein kinase 12.7.11.10.486
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
3fmkFMKMitogen-activated protein kinase 14/0.485
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.485
1m17AQ4Epidermal growth factor receptor2.7.10.10.484
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.484
4gk3L87Ephrin type-A receptor 32.7.10.10.484
4looSB4Mitogen-activated protein kinase 14/0.484
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.484
3flzFLZMitogen-activated protein kinase 14/0.483
3uibSB2Putative mitogen-activated protein kinase/0.483
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
2fgiPD1Fibroblast growth factor receptor 1/0.482
2of4979Tyrosine-protein kinase Lck2.7.10.20.482
3fkoFKOMitogen-activated protein kinase 14/0.482
1m7qDQOMitogen-activated protein kinase 14/0.481
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
2itzIREEpidermal growth factor receptor2.7.10.10.479
3fmn530Mitogen-activated protein kinase 14/0.479
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.478
2of2547Tyrosine-protein kinase Lck2.7.10.20.477
2qd9LGFMitogen-activated protein kinase 14/0.476
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
2hk51BMTyrosine-protein kinase HCK2.7.10.20.474
3vjoANPEpidermal growth factor receptor2.7.10.10.474
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.474
4gk2L66Ephrin type-A receptor 32.7.10.10.474
2eb3ANPEpidermal growth factor receptor2.7.10.10.473
4hvh19RTyrosine-protein kinase JAK32.7.10.20.473
4i231C9Epidermal growth factor receptor2.7.10.10.473
4jr3KJREpidermal growth factor receptor2.7.10.10.473
1di9MSQMitogen-activated protein kinase 14/0.472
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.472
3nwxKVSGag-Pol polyprotein3.4.23.160.472
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.471
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.471
3ocgOCGMitogen-activated protein kinase 14/0.471
1ouy094Mitogen-activated protein kinase 14/0.470
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.470
1ove358Mitogen-activated protein kinase 14/0.469
3bheBZNGag-Pol polyprotein3.4.23.160.469
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.469
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.469
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.468
5e8xSTUTGF-beta receptor type-12.7.11.300.468
3bv3P39Mitogen-activated protein kinase 14/0.467
4jq8KJ8Epidermal growth factor receptor2.7.10.10.467
2itqITQEpidermal growth factor receptor2.7.10.10.466
3ac1KZITyrosine-protein kinase Lck2.7.10.20.466
4loqSB4Mitogen-activated protein kinase 14/0.466
4nfn2KCTau-tubulin kinase 12.7.11.10.466
4yuqKS1Calmodulin-like domain protein kinase/0.466
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.465
2qo9ANPEphrin type-A receptor 32.7.10.10.465
4j97ACPFibroblast growth factor receptor 2/0.465
2excJNKMitogen-activated protein kinase 102.7.11.240.464
2y6o1N1Ephrin type-A receptor 42.7.10.10.464
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.463
4eh70OOMitogen-activated protein kinase 14/0.463
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.463
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.462
3zh8C58Protein kinase C iota type2.7.11.130.462
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.462
4g1wG1WMitogen-activated protein kinase 82.7.11.240.462
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.461
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.461
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.461
2itpAEEEpidermal growth factor receptor2.7.10.10.461
2vd5BI8Myotonin-protein kinase2.7.11.10.461
4ansVGHALK tyrosine kinase receptor2.7.10.10.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.461
4qnaX11Serine/threonine-protein kinase 242.7.11.10.461
1zz2B11Mitogen-activated protein kinase 14/0.460
2hog710Serine/threonine-protein kinase Chk12.7.11.10.460
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.460
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.460
3a62STURibosomal protein S6 kinase beta-12.7.11.10.460
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.460
3o8tBMUMitogen-activated protein kinase 14/0.460
4cd2FOLDihydrofolate reductase1.5.1.30.460
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.459
4ewqMWLMitogen-activated protein kinase 14/0.459
4j55031Gag-Pol polyprotein3.4.23.160.459
4jq7KJQEpidermal growth factor receptor2.7.10.10.459
2itwITQEpidermal growth factor receptor2.7.10.10.458
3fc152PMitogen-activated protein kinase 14/0.458
4hvg19QTyrosine-protein kinase JAK32.7.10.20.458
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
1finATPCyclin-dependent kinase 22.7.11.220.457
2i0ePDSProtein kinase C beta type2.7.11.130.457
3el4ROCGag-Pol polyprotein3.4.23.160.457
3obgSB2Mitogen-activated protein kinase 14/0.457
3zewSTUEphrin type-B receptor 42.7.10.10.457
4cd0AWJALK tyrosine kinase receptor2.7.10.10.457
4dce0JFALK tyrosine kinase receptor2.7.10.10.457
4fnzNZFALK tyrosine kinase receptor2.7.10.10.457
4j5j478Gag-Pol polyprotein3.4.23.160.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.457
1ida0POGag-Pol polyprotein3.4.23.470.456
1zzlTZYMitogen-activated protein kinase 14/0.456
3ds6A17Mitogen-activated protein kinase 14/0.456
3hvcGG5Mitogen-activated protein kinase 14/0.456
3zsh469Mitogen-activated protein kinase 14/0.456
4ic7ANPMitogen-activated protein kinase 72.7.11.240.456
4jrvKJVEpidermal growth factor receptor2.7.10.10.456
5aaaVGHALK tyrosine kinase receptor2.7.10.10.456
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
2yfxVGHALK tyrosine kinase receptor2.7.10.10.455
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.455
3gxlQIGTGF-beta receptor type-12.7.11.300.455
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.455
4bcqTJFCyclin-dependent kinase 22.7.11.220.455
5aacVGHALK tyrosine kinase receptor2.7.10.10.455
1hvsA77Gag-Pol polyprotein/0.454
2henADPEphrin type-B receptor 22.7.10.10.454
3fl4FL4Mitogen-activated protein kinase 14/0.454
3gi6D78Gag-Pol polyprotein/0.454
3ha85JZMitogen-activated protein kinase 14/0.454
3nwq2NCGag-Pol polyprotein3.4.23.160.454
4gk4L90Ephrin type-A receptor 32.7.10.10.454
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2f3kRO1Protease/0.453
2itnANPEpidermal growth factor receptor2.7.10.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
2pvyACPFibroblast growth factor receptor 2/0.453
3gc7B45Mitogen-activated protein kinase 14/0.453
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.453
4ye3G04Gag-Pol polyprotein3.4.23.160.453
1d4lPI9Gag-Pol polyprotein3.4.23.160.452
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.452
3em6017Gag-Pol polyprotein3.4.23.160.452
3fknFKNMitogen-activated protein kinase 14/0.452
3qpjN4IGag-Pol polyprotein3.4.23.160.452
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.452
4j54G52Gag-Pol polyprotein3.4.23.160.452
4y95746Tyrosine-protein kinase/0.452
1bl6SB6Mitogen-activated protein kinase 14/0.451
1k6cMK1Gag-Pol polyprotein3.4.23.160.451
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.451
4hyu1BKMitogen-activated protein kinase 82.7.11.240.451
1bxoPP7Penicillopepsin-13.4.23.200.450
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2aidTHKGag-Pol polyprotein3.4.23.160.450
2py3ACPFibroblast growth factor receptor 2/0.450
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.450
3w33W19Epidermal growth factor receptor2.7.10.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.450
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.450
5f0a1FBcGMP-dependent protein kinase, putative/0.450
2qoqANPEphrin type-A receptor 32.7.10.10.449
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3mvm39PMitogen-activated protein kinase 14/0.449
1agwSU2Fibroblast growth factor receptor 1/0.448
2aquDR7Gag-Pol polyprotein3.4.23.160.448
2qd7065Gag-Pol polyprotein3.4.23.160.448
3fmmXI2Mitogen-activated protein kinase 14/0.448
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.448
3tnwF18Cyclin-dependent kinase 22.7.11.220.448
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.448
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.447
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.447
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.447
4njt017Protease/0.447
1ppm0P1Penicillopepsin-13.4.23.200.446
2h96893Mitogen-activated protein kinase 82.7.11.240.446
2zazGK1Mitogen-activated protein kinase 14/0.446
3ekp478Gag-Pol polyprotein3.4.23.160.446
3nduROCGag-Pol polyprotein3.4.23.160.446
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4e4m0NHTyrosine-protein kinase JAK2/0.446
1yw2PGJMitogen-activated protein kinase 14/0.445
2vwz7X6Ephrin type-B receptor 42.7.10.10.445
3kf7L9GMitogen-activated protein kinase 14/0.445
3och2MXDihydrofolate reductase1.5.1.30.445
3ttp017Gag-Pol polyprotein3.4.23.160.445
5dr9SKEAurora kinase A2.7.11.10.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
1kzkJE2Gag-Pol polyprotein3.4.23.160.444
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.444
1t7i017Gag-Pol polyprotein3.4.23.160.444
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
3dcrKVSProtease/0.444
3w2rW2REpidermal growth factor receptor2.7.10.10.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1xkkFMMEpidermal growth factor receptor2.7.10.10.443
2qd8065Gag-Pol polyprotein3.4.23.160.443
2qnqQN3Gag-Pol polyprotein3.4.23.160.443
2vx07X7Ephrin type-B receptor 42.7.10.10.443
2vx17X8Ephrin type-B receptor 42.7.10.10.443
3nbwTR4Ketohexokinase/0.443
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.443
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2f8g017Gag-Pol polyprotein3.4.23.160.442
2nnpROCProtease/0.442
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.442
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.442
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.442
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.442
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.442
2zybKSLTyrosine-protein kinase Lck2.7.10.20.442
3bgbLJGGag-Pol polyprotein3.4.23.160.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3gstGPRGlutathione S-transferase Mu 12.5.1.180.442
3qp0NI8Gag-Pol polyprotein3.4.23.160.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
4r20AERCytochrome P450 family 17 polypeptide 2/0.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.441
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.441
3nu3478Gag-Pol polyprotein3.4.23.160.441
3q5iANPProtein kinase, putative/0.441
3qrsNK8Gag-Pol polyprotein3.4.23.160.441
3rinI2OMitogen-activated protein kinase 14/0.441
3ttjJBIMitogen-activated protein kinase 102.7.11.240.441
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.441
4hys1BJMitogen-activated protein kinase 82.7.11.240.441
4ix4ADPUncharacterized protein/0.441
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.440
1vikBAYGag-Pol polyprotein/0.440
2r43G3GGag-Pol polyprotein3.4.23.160.440
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.440
3bx5304Mitogen-activated protein kinase 14/0.440
3igoANPCalmodulin-domain protein kinase 1, putative/0.440
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.440
4b7sQLECytochrome P450 monooxygenase PikC/0.440
4e730NRMitogen-activated protein kinase 82.7.11.240.440
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.440
4nj32KDCyclin-dependent kinase 22.7.11.220.440
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440