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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rzb02ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rzb02ZCyclin-dependent kinase 22.7.11.221.000
1vyzN5BCyclin-dependent kinase 22.7.11.220.602
4fkt48KCyclin-dependent kinase 22.7.11.220.601
1gih1PUCyclin-dependent kinase 22.7.11.220.587
1p2a5BNCyclin-dependent kinase 22.7.11.220.587
3qzfX66Cyclin-dependent kinase 22.7.11.220.587
3rpy27ZCyclin-dependent kinase 22.7.11.220.587
1v1k3FPCyclin-dependent kinase 22.7.11.220.586
1ykr628Cyclin-dependent kinase 22.7.11.220.583
3rpv26ZCyclin-dependent kinase 22.7.11.220.583
3qtuX44Cyclin-dependent kinase 22.7.11.220.581
3ezvEZVCyclin-dependent kinase 22.7.11.220.579
3s0o50ZCyclin-dependent kinase 22.7.11.220.573
3qzgX67Cyclin-dependent kinase 22.7.11.220.572
1fvt106Cyclin-dependent kinase 22.7.11.220.571
1pxmCK5Cyclin-dependent kinase 22.7.11.220.570
3rk507ZCyclin-dependent kinase 22.7.11.220.570
3ti1B49Cyclin-dependent kinase 22.7.11.220.569
4ek610KCyclin-dependent kinase 22.7.11.220.568
4bgh3I6Cyclin-dependent kinase 22.7.11.220.566
3ral04ZCyclin-dependent kinase 22.7.11.220.564
2r3lSCWCyclin-dependent kinase 22.7.11.220.560
3r7eX88Cyclin-dependent kinase 22.7.11.220.559
3rm719ZCyclin-dependent kinase 22.7.11.220.557
3qtrX36Cyclin-dependent kinase 22.7.11.220.556
3r1sX73Cyclin-dependent kinase 22.7.11.220.554
3qxoX65Cyclin-dependent kinase 22.7.11.220.552
3unk0BYCyclin-dependent kinase 22.7.11.220.552
2xmyCDKCyclin-dependent kinase 22.7.11.220.551
3rjc06ZCyclin-dependent kinase 22.7.11.220.551
3qzhX69Cyclin-dependent kinase 22.7.11.220.550
2c6iDT1Cyclin-dependent kinase 22.7.11.220.549
1g5sI17Cyclin-dependent kinase 22.7.11.220.548
2btrU73Cyclin-dependent kinase 22.7.11.220.548
1pxkCK3Cyclin-dependent kinase 22.7.11.220.547
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.547
3rk708ZCyclin-dependent kinase 22.7.11.220.547
3s2pPMUCyclin-dependent kinase 22.7.11.220.546
1oguST8Cyclin-dependent kinase 22.7.11.220.545
3fz1B98Cyclin-dependent kinase 22.7.11.220.545
3roy22ZCyclin-dependent kinase 22.7.11.220.545
1ckpPVBCyclin-dependent kinase 22.7.11.220.544
1ke7LS3Cyclin-dependent kinase 22.7.11.220.544
1ke9LS5Cyclin-dependent kinase 22.7.11.220.544
2r64740Cyclin-dependent kinase 22.7.11.220.544
3qqhX0ACyclin-dependent kinase 22.7.11.220.544
3rk909ZCyclin-dependent kinase 22.7.11.220.544
2r3p3SCCyclin-dependent kinase 22.7.11.220.542
2w1hL0FCyclin-dependent kinase 22.7.11.220.542
4fkr45KCyclin-dependent kinase 22.7.11.220.542
2vthLZ2Cyclin-dependent kinase 22.7.11.220.541
3rni21ZCyclin-dependent kinase 22.7.11.220.541
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.540
3py0SU9Cyclin-dependent kinase 22.7.11.220.540
1ke5LS1Cyclin-dependent kinase 22.7.11.220.539
4ez30S0Cyclin-dependent kinase 22.7.11.220.539
1urwI1PCyclin-dependent kinase 22.7.11.220.538
1oiqHDUCyclin-dependent kinase 22.7.11.220.537
3qqfX07Cyclin-dependent kinase 22.7.11.220.537
3qtzX42Cyclin-dependent kinase 22.7.11.220.537
3qqkX02Cyclin-dependent kinase 22.7.11.220.536
3qtxX43Cyclin-dependent kinase 22.7.11.220.535
3r9dX6BCyclin-dependent kinase 22.7.11.220.535
4fkq42KCyclin-dependent kinase 22.7.11.220.535
1dm2HMDCyclin-dependent kinase 22.7.11.220.534
4fkg4CKCyclin-dependent kinase 22.7.11.220.534
2c6o4SPCyclin-dependent kinase 22.7.11.220.533
4fkpLS5Cyclin-dependent kinase 22.7.11.220.533
4fx360KCyclin-dependent kinase 22.7.11.220.533
3ig7EFPCyclin-dependent kinase 22.7.11.220.532
2vv9IM9Cyclin-dependent kinase 22.7.11.220.531
1w0xOLOCyclin-dependent kinase 22.7.11.220.529
2b52D42Cyclin-dependent kinase 22.7.11.220.528
2r3r6SCCyclin-dependent kinase 22.7.11.220.528
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.528
3r6xX84Cyclin-dependent kinase 22.7.11.220.528
3r73X87Cyclin-dependent kinase 22.7.11.220.528
1oiyN41Cyclin-dependent kinase 22.7.11.220.527
2r3iSCFCyclin-dependent kinase 22.7.11.220.527
2btsU32Cyclin-dependent kinase 22.7.11.220.526
2w06FRVCyclin-dependent kinase 22.7.11.220.526
3rmf20ZCyclin-dependent kinase 22.7.11.220.526
4acm7YGCyclin-dependent kinase 22.7.11.220.526
4fks46KCyclin-dependent kinase 22.7.11.220.525
1r78FMDCyclin-dependent kinase 22.7.11.220.524
4fko20KCyclin-dependent kinase 22.7.11.220.524
1ke6LS2Cyclin-dependent kinase 22.7.11.220.523
2uzoC62Cyclin-dependent kinase 22.7.11.220.523
3lfnA27Cyclin-dependent kinase 22.7.11.220.522
3qu0X40Cyclin-dependent kinase 22.7.11.220.521
1pxoCK7Cyclin-dependent kinase 22.7.11.220.519
1oi9N20Cyclin-dependent kinase 22.7.11.220.518
2iw94SPCyclin-dependent kinase 22.7.11.220.518
2a0cCK9Cyclin-dependent kinase 22.7.11.220.517
3ddqRRCCyclin-dependent kinase 22.7.11.220.516
3iggEFQCyclin-dependent kinase 22.7.11.220.514
1h1s4SPCyclin-dependent kinase 22.7.11.220.513
2r3o2SCCyclin-dependent kinase 22.7.11.220.513
2b55D31Cyclin-dependent kinase 22.7.11.220.512
2wpa889Cyclin-dependent kinase 22.7.11.220.512
2b54D05Cyclin-dependent kinase 22.7.11.220.511
3qtqX35Cyclin-dependent kinase 22.7.11.220.511
3r28XA0Cyclin-dependent kinase 22.7.11.220.511
1ke8LS4Cyclin-dependent kinase 22.7.11.220.510
3rpo24ZCyclin-dependent kinase 22.7.11.220.510
3pj8404Cyclin-dependent kinase 22.7.11.220.509
3r7uX96Cyclin-dependent kinase 22.7.11.220.509
4fki09KCyclin-dependent kinase 22.7.11.220.509
1vyw292Cyclin-dependent kinase 22.7.11.220.507
2r3kSCQCyclin-dependent kinase 22.7.11.220.507
3r9hZ67Cyclin-dependent kinase 22.7.11.220.507
2duv371Cyclin-dependent kinase 22.7.11.220.506
3ddpRC8Cyclin-dependent kinase 22.7.11.220.506
4lyn1YGCyclin-dependent kinase 22.7.11.220.506
2j9mPY8Cyclin-dependent kinase 22.7.11.220.504
3sqq99ZCyclin-dependent kinase 22.7.11.220.504
3uli1N3Cyclin-dependent kinase 22.7.11.220.503
4eok4SPCyclin-dependent kinase 22.7.11.220.503
1di8DTQCyclin-dependent kinase 22.7.11.220.502
4ek816KCyclin-dependent kinase 22.7.11.220.502
1gii1PUCyclin-dependent kinase 22.7.11.220.501
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.500
2xnbY8LCyclin-dependent kinase 22.7.11.220.500
3r7vZ02Cyclin-dependent kinase 22.7.11.220.500
2r3jSCJCyclin-dependent kinase 22.7.11.220.499
3qwkX62Cyclin-dependent kinase 22.7.11.220.499
1h1r6CPCyclin-dependent kinase 22.7.11.220.498
4fkj11KCyclin-dependent kinase 22.7.11.220.498
1b39ATPCyclin-dependent kinase 22.7.11.220.496
2iw84SPCyclin-dependent kinase 22.7.11.220.494
3qwjX6ACyclin-dependent kinase 22.7.11.220.494
2wxvWXVCyclin-dependent kinase 22.7.11.220.493
3raiX85Cyclin-dependent kinase 22.7.11.220.493
3rak03ZCyclin-dependent kinase 22.7.11.220.493
2bheBRYCyclin-dependent kinase 22.7.11.220.492
2w17I19Cyclin-dependent kinase 22.7.11.220.492
3s1h56ZCyclin-dependent kinase 22.7.11.220.492
4bcpT3CCyclin-dependent kinase 22.7.11.220.492
1h0vUN4Cyclin-dependent kinase 22.7.11.220.491
1oitHDTCyclin-dependent kinase 22.7.11.220.490
2r3mSCXCyclin-dependent kinase 22.7.11.220.489
3lfsA07Cyclin-dependent kinase 22.7.11.220.489
3qtsX46Cyclin-dependent kinase 22.7.11.220.489
3sw719KCyclin-dependent kinase 22.7.11.220.489
3r9oZ71Cyclin-dependent kinase 22.7.11.220.488
3sw418KCyclin-dependent kinase 22.7.11.220.488
1h0w207Cyclin-dependent kinase 22.7.11.220.487
4fkw62KCyclin-dependent kinase 22.7.11.220.487
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.486
3unj0BXCyclin-dependent kinase 22.7.11.220.486
2uzlC94Cyclin-dependent kinase 22.7.11.220.484
2wihP48Cyclin-dependent kinase 22.7.11.220.484
3pxyJWSCyclin-dependent kinase 22.7.11.220.484
3r1qX75Cyclin-dependent kinase 22.7.11.220.484
4fkv61KCyclin-dependent kinase 22.7.11.220.483
3tiz3TICyclin-dependent kinase 22.7.11.220.482
5aniES4Cyclin-dependent kinase 22.7.11.220.482
2vttLZDCyclin-dependent kinase 22.7.11.220.481
3r71X86Cyclin-dependent kinase 22.7.11.220.481
3rpr25ZCyclin-dependent kinase 22.7.11.220.481
4eos1ROCyclin-dependent kinase 22.7.11.220.481
2uznC96Cyclin-dependent kinase 22.7.11.220.480
3s00Z60Cyclin-dependent kinase 22.7.11.220.480
4eor4SPCyclin-dependent kinase 22.7.11.220.480
1gij2PUCyclin-dependent kinase 22.7.11.220.479
1pyePM1Cyclin-dependent kinase 22.7.11.220.479
2i40BLZCyclin-dependent kinase 22.7.11.220.478
4qmpDKISerine/threonine-protein kinase 242.7.11.10.478
1e1vCMGCyclin-dependent kinase 22.7.11.220.477
4eol1ROCyclin-dependent kinase 22.7.11.220.477
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.476
3wblPDYCyclin-dependent kinase 22.7.11.220.476
4eon1ROCyclin-dependent kinase 22.7.11.220.476
4eop1ROCyclin-dependent kinase 22.7.11.220.476
4kd11QKCyclin-dependent kinase 22.7.11.220.476
2bhhRYUCyclin-dependent kinase 22.7.11.220.475
4erwSTUCyclin-dependent kinase 22.7.11.220.475
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
2fvdLIACyclin-dependent kinase 22.7.11.220.474
1pxpCK8Cyclin-dependent kinase 22.7.11.220.472
3qrtX14Cyclin-dependent kinase 22.7.11.220.472
4eomATPCyclin-dependent kinase 22.7.11.220.472
1fvv107Cyclin-dependent kinase 22.7.11.220.471
2w05FRTCyclin-dependent kinase 22.7.11.220.471
2r3fSC8Cyclin-dependent kinase 22.7.11.220.470
3r8zZ63Cyclin-dependent kinase 22.7.11.220.470
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.469
4lopSB4Mitogen-activated protein kinase 14/0.468
4nj32KDCyclin-dependent kinase 22.7.11.220.468
2vtsLZCCyclin-dependent kinase 22.7.11.220.467
3lfqA28Cyclin-dependent kinase 22.7.11.220.467
2c69CT8Cyclin-dependent kinase 22.7.11.220.466
1finATPCyclin-dependent kinase 22.7.11.220.464
3dogNNNCyclin-dependent kinase 22.7.11.220.464
3r8vZ62Cyclin-dependent kinase 22.7.11.220.464
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.464
2a4lRRCCyclin-dependent kinase 22.7.11.220.463
2r3gSC9Cyclin-dependent kinase 22.7.11.220.463
2x1nX1NCyclin-dependent kinase 22.7.11.220.463
1h1pCMGCyclin-dependent kinase 22.7.11.220.461
2c5nCK8Cyclin-dependent kinase 22.7.11.220.461
3qx2X63Cyclin-dependent kinase 22.7.11.220.461
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.460
3qruX19Cyclin-dependent kinase 22.7.11.220.460
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.460
1e9hINRCyclin-dependent kinase 22.7.11.220.459
1pkdUCNCyclin-dependent kinase 22.7.11.220.459
2c6mDT5Cyclin-dependent kinase 22.7.11.220.459
3qtwX3ACyclin-dependent kinase 22.7.11.220.459
4cfnJYMCyclin-dependent kinase 22.7.11.220.459
1oiuN76Cyclin-dependent kinase 22.7.11.220.458
2c6tDT5Cyclin-dependent kinase 22.7.11.220.458
2eufLQQCyclin-dependent kinase 62.7.11.220.458
2r3q5SCCyclin-dependent kinase 22.7.11.220.458
3ggfGVDSerine/threonine-protein kinase 26/0.457
3rkb12ZCyclin-dependent kinase 22.7.11.220.457
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.456
3qziX72Cyclin-dependent kinase 22.7.11.220.455
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.455
4loqSB4Mitogen-activated protein kinase 14/0.455
1unlRRCCyclin-dependent-like kinase 52.7.11.10.454
4bcnT9NCyclin-dependent kinase 22.7.11.220.454
4eoi1ROCyclin-dependent kinase 22.7.11.220.454
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.453
3qn8NI7Gag-Pol polyprotein3.4.23.160.453
3r8uZ31Cyclin-dependent kinase 22.7.11.220.453
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.452
4bcoT6QCyclin-dependent kinase 22.7.11.220.452
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1e1xNW1Cyclin-dependent kinase 22.7.11.220.450
2c4g514Cyclin-dependent kinase 22.7.11.220.450
3ql8X01Cyclin-dependent kinase 22.7.11.220.450
1h1q2A6Cyclin-dependent kinase 22.7.11.220.449
3sheI85MAP kinase-activated protein kinase 32.7.11.10.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
1w8cN69Cyclin-dependent kinase 22.7.11.220.448
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.448
2cchATPCyclin-dependent kinase 22.7.11.220.447
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
1gy3ATPCyclin-dependent kinase 22.7.11.220.446
3ezrEZRCyclin-dependent kinase 22.7.11.220.446
4ivd15TTyrosine-protein kinase JAK1/0.446
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.445
1xjdSTUProtein kinase C theta type2.7.11.130.443
2fxdDR7Pol polyprotein/0.443
3lixE17Protease/0.443
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
3tl9ROCGag-Pol polyprotein3.4.23.160.442
1zsr0ZTGag-Pol polyprotein3.4.23.160.441
2uzdC85Cyclin-dependent kinase 22.7.11.220.441
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.441
2vu3LZECyclin-dependent kinase 22.7.11.220.440
3cid318Beta-secretase 13.4.23.460.440
3r7iX9ICyclin-dependent kinase 22.7.11.220.440
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.440