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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rs7GNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rs7GNPGTPase HRas/1.000
3rs5GNPGTPase HRas/0.739
3oivGNPGTPase HRas/0.727
3lbnGNPGTPase HRas/0.693
3i3sGNPGTPase HRas/0.625
5b2zGNPGTPase HRas/0.624
2rgbGNPGTPase HRas/0.611
4dlwGNPGTPase HRas/0.611
4dlzGNPGTPase HRas/0.610
3oiuGNPGTPase HRas/0.609
4dlsGNPGTPase HRas/0.609
4dltGNPGTPase HRas/0.590
5dhaGNPGTP-binding nuclear protein Ran/0.587
3v4fGNPGTPase HRas/0.576
3rslGNPGTPase HRas/0.566
3rabGNPRas-related protein Rab-3A/0.564
4mitGTPRho-related protein racC/0.564
2rgcGNPGTPase HRas/0.555
4dlxGNPGTPase HRas/0.555
4nyiGNPGTPase HRas/0.551
4dlvGNPGTPase HRas/0.548
1m7bGTPRho-related GTP-binding protein RhoE/0.547
1g17GNPRas-related protein SEC4/0.546
1zc3GNPRas-related protein Ral-A/0.545
3kucGDPRas-related protein Rap-1A/0.539
4lhwGNPRas-related protein Rab-8A/0.539
4g0nGNPGTPase HRas/0.536
1kmqGNPTransforming protein RhoA/0.535
3rs0GNPGTPase HRas/0.530
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.529
4kvgGTPRas-related protein Rap-1A/0.526
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.524
1zc4GNPRas-related protein Ral-A/0.521
1cxzGSPTransforming protein RhoA/0.519
1zd9GDPADP-ribosylation factor-like protein 8A/0.518
3ea5GDPGTP-binding nuclear protein Ran/0.518
5jljGNPGTP-binding nuclear protein Ran/0.516
2rgeGNPGTPase HRas/0.514
1xtrGNPGTP-binding protein Rheb/0.513
3l8yGNPGTPase HRas/0.513
4qxaGTPRas-related protein Rab-9A/0.512
5difGNPGTP-binding nuclear protein Ran/0.511
1ibrGNPGTP-binding nuclear protein Ran/0.509
1uadGNPRas-related protein Ral-A/0.508
1xtsGTPGTP-binding protein Rheb/0.506
1yzqGNPRas-related protein Rab-6A/0.506
1oixGDPRas-related protein Rab-11A/0.504
4dsuGDPGTPase KRas/0.504
3bc1GNPRas-related protein Rab-27A/0.503
3oiwGNPGTPase HRas/0.502
3tsoGNPRas-related protein Rab-25/0.502
3pitGNPRas-related protein M-Ras/0.497
3a6pGTPGTP-binding nuclear protein Ran/0.495
4xoiGTPTransforming protein RhoA/0.495
3rs4GNPGTPase HRas/0.494
4nyjGNPGTPase HRas/0.493
4dxaGSPRas-related protein Rap-1b/0.492
3ddcGNPGTPase HRas/0.491
1s1cGNPTransforming protein RhoA/0.490
2gcpGSPRho-related GTP-binding protein RhoC/0.489
5hpyGDPTransforming protein RhoA/0.488
3kkoGNPRas-related protein M-Ras/0.486
1t91GTPRas-related protein Rab-7a/0.485
1zbdGTPRas-related protein Rab-3A/0.485
3a58GNPGTP-binding protein RHO1/0.485
4dsnGCPGTPase KRas/0.484
2c5lGTPGTPase HRas/0.482
3tnfGNPRas-related protein Rab-8A/0.481
3oesGNPGTPase RhebL1/0.480
2zetGTPRas-related protein Rab-27B/0.477
4rkfGNPRas-related protein Rab-3/0.477
3bbpGTPRas-related protein Rab-6A/0.475
3kz1GSPTransforming protein RhoA/0.475
4l9wGNPGTPase HRas/0.475
3nbzGTPGTP-binding nuclear protein Ran/0.472
1ow3GDPTransforming protein RhoA/0.471
1e96GTPRas-related C3 botulinum toxin substrate 1/0.469
4ol0GTPGTP-binding nuclear protein Ran/0.468
3w3zGTPGTP-binding nuclear protein Ran/0.467
4cymGCPRas-related protein Rab-32/0.465
3e5hGNPRas-related protein Rab-28/0.464
3kudGDPGTPase HRas/0.460
2bkuGTPGTP-binding nuclear protein Ran/0.459
4hdoGNPRas-related protein Rap-1b/0.459
4uj3GNPRas-related protein Rab-11A/0.458
3qbtGNPRas-related protein Rab-8A/0.453
2clsGTPRho-related GTP-binding protein Rho6/0.452
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.450
3eg5GNPCell division control protein 42 homolog/0.449
4js0GNPCell division control protein 42 homolog/0.444
4hdqGNPRas-related protein Rap-1b/0.443
1yhnGTPRas-related protein Rab-7a/0.442
2gilGTPRas-related protein Rab-6A/0.440
4o25GTPGTP-binding protein Rheb/0.440