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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rpr25ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rpr25ZCyclin-dependent kinase 22.7.11.221.000
3r9nZ68Cyclin-dependent kinase 22.7.11.220.640
3qtsX46Cyclin-dependent kinase 22.7.11.220.614
1w8cN69Cyclin-dependent kinase 22.7.11.220.548
3s00Z60Cyclin-dependent kinase 22.7.11.220.547
3qzgX67Cyclin-dependent kinase 22.7.11.220.546
1e1xNW1Cyclin-dependent kinase 22.7.11.220.545
3s0o50ZCyclin-dependent kinase 22.7.11.220.545
1h0w207Cyclin-dependent kinase 22.7.11.220.538
3r71X86Cyclin-dependent kinase 22.7.11.220.538
2c69CT8Cyclin-dependent kinase 22.7.11.220.537
5aniES4Cyclin-dependent kinase 22.7.11.220.532
3r8uZ31Cyclin-dependent kinase 22.7.11.220.531
3iggEFQCyclin-dependent kinase 22.7.11.220.523
3raiX85Cyclin-dependent kinase 22.7.11.220.520
2c6mDT5Cyclin-dependent kinase 22.7.11.220.519
1h1r6CPCyclin-dependent kinase 22.7.11.220.514
3r9hZ67Cyclin-dependent kinase 22.7.11.220.514
3qtrX36Cyclin-dependent kinase 22.7.11.220.513
3rpv26ZCyclin-dependent kinase 22.7.11.220.512
2r3gSC9Cyclin-dependent kinase 22.7.11.220.511
3qwjX6ACyclin-dependent kinase 22.7.11.220.507
3my5RFZCyclin-dependent kinase 22.7.11.220.506
3qruX19Cyclin-dependent kinase 22.7.11.220.504
3r9dX6BCyclin-dependent kinase 22.7.11.220.504
3rpo24ZCyclin-dependent kinase 22.7.11.220.504
2c6o4SPCyclin-dependent kinase 22.7.11.220.503
4fkj11KCyclin-dependent kinase 22.7.11.220.502
3qx2X63Cyclin-dependent kinase 22.7.11.220.501
3qqkX02Cyclin-dependent kinase 22.7.11.220.500
2c6iDT1Cyclin-dependent kinase 22.7.11.220.498
3rm719ZCyclin-dependent kinase 22.7.11.220.498
3r1sX73Cyclin-dependent kinase 22.7.11.220.497
3rk909ZCyclin-dependent kinase 22.7.11.220.497
2w06FRVCyclin-dependent kinase 22.7.11.220.496
3pj8404Cyclin-dependent kinase 22.7.11.220.496
3qzhX69Cyclin-dependent kinase 22.7.11.220.496
3qqhX0ACyclin-dependent kinase 22.7.11.220.491
3r28XA0Cyclin-dependent kinase 22.7.11.220.491
3r73X87Cyclin-dependent kinase 22.7.11.220.490
2vtsLZCCyclin-dependent kinase 22.7.11.220.489
4eos1ROCyclin-dependent kinase 22.7.11.220.489
4ez30S0Cyclin-dependent kinase 22.7.11.220.488
3qtuX44Cyclin-dependent kinase 22.7.11.220.487
3unk0BYCyclin-dependent kinase 22.7.11.220.487
1w0xOLOCyclin-dependent kinase 22.7.11.220.485
1g5sI17Cyclin-dependent kinase 22.7.11.220.484
1v1k3FPCyclin-dependent kinase 22.7.11.220.483
1ke6LS2Cyclin-dependent kinase 22.7.11.220.482
1pxmCK5Cyclin-dependent kinase 22.7.11.220.482
4fkq42KCyclin-dependent kinase 22.7.11.220.482
1e1vCMGCyclin-dependent kinase 22.7.11.220.481
3ig7EFPCyclin-dependent kinase 22.7.11.220.481
1ke5LS1Cyclin-dependent kinase 22.7.11.220.479
4eol1ROCyclin-dependent kinase 22.7.11.220.479
3roy22ZCyclin-dependent kinase 22.7.11.220.478
4eor4SPCyclin-dependent kinase 22.7.11.220.478
2btsU32Cyclin-dependent kinase 22.7.11.220.477
4acm7YGCyclin-dependent kinase 22.7.11.220.477
2b55D31Cyclin-dependent kinase 22.7.11.220.476
3r6xX84Cyclin-dependent kinase 22.7.11.220.476
2btrU73Cyclin-dependent kinase 22.7.11.220.475
3qtwX3ACyclin-dependent kinase 22.7.11.220.472
4fklCK2Cyclin-dependent kinase 22.7.11.220.471
1gii1PUCyclin-dependent kinase 22.7.11.220.470
2vu3LZECyclin-dependent kinase 22.7.11.220.470
3qqfX07Cyclin-dependent kinase 22.7.11.220.470
1b38ATPCyclin-dependent kinase 22.7.11.220.469
3qtxX43Cyclin-dependent kinase 22.7.11.220.469
1vyzN5BCyclin-dependent kinase 22.7.11.220.468
2r3r6SCCyclin-dependent kinase 22.7.11.220.468
2fvdLIACyclin-dependent kinase 22.7.11.220.467
2r3fSC8Cyclin-dependent kinase 22.7.11.220.467
3fz1B98Cyclin-dependent kinase 22.7.11.220.467
3qtqX35Cyclin-dependent kinase 22.7.11.220.467
3qwkX62Cyclin-dependent kinase 22.7.11.220.467
3rk708ZCyclin-dependent kinase 22.7.11.220.467
4eoi1ROCyclin-dependent kinase 22.7.11.220.467
1ke9LS5Cyclin-dependent kinase 22.7.11.220.466
3qqlX03Cyclin-dependent kinase 22.7.11.220.466
3s2pPMUCyclin-dependent kinase 22.7.11.220.466
4fko20KCyclin-dependent kinase 22.7.11.220.466
1r78FMDCyclin-dependent kinase 22.7.11.220.465
2wotZZGTGF-beta receptor type-12.7.11.300.465
1h1pCMGCyclin-dependent kinase 22.7.11.220.464
1h1s4SPCyclin-dependent kinase 22.7.11.220.464
1ke7LS3Cyclin-dependent kinase 22.7.11.220.464
1oguST8Cyclin-dependent kinase 22.7.11.220.464
3qu0X40Cyclin-dependent kinase 22.7.11.220.464
3qxoX65Cyclin-dependent kinase 22.7.11.220.464
2r3o2SCCyclin-dependent kinase 22.7.11.220.463
3py0SU9Cyclin-dependent kinase 22.7.11.220.463
3r8lZ30Cyclin-dependent kinase 22.7.11.220.463
3rmf20ZCyclin-dependent kinase 22.7.11.220.462
3unj0BXCyclin-dependent kinase 22.7.11.220.462
2iw84SPCyclin-dependent kinase 22.7.11.220.461
1di8DTQCyclin-dependent kinase 22.7.11.220.460
3rjc06ZCyclin-dependent kinase 22.7.11.220.460
1vyw292Cyclin-dependent kinase 22.7.11.220.459
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.459
3ddpRC8Cyclin-dependent kinase 22.7.11.220.459
4fkpLS5Cyclin-dependent kinase 22.7.11.220.459
3ddqRRCCyclin-dependent kinase 22.7.11.220.458
3r7eX88Cyclin-dependent kinase 22.7.11.220.458
4eon1ROCyclin-dependent kinase 22.7.11.220.458
3r7vZ02Cyclin-dependent kinase 22.7.11.220.457
3rkb12ZCyclin-dependent kinase 22.7.11.220.457
3ti1B49Cyclin-dependent kinase 22.7.11.220.457
4fkw62KCyclin-dependent kinase 22.7.11.220.457
4i3zADPCyclin-dependent kinase 22.7.11.220.457
4qmpDKISerine/threonine-protein kinase 242.7.11.10.457
1ckpPVBCyclin-dependent kinase 22.7.11.220.456
1gy3ATPCyclin-dependent kinase 22.7.11.220.456
1h0vUN4Cyclin-dependent kinase 22.7.11.220.456
2j9mPY8Cyclin-dependent kinase 22.7.11.220.456
3r8pZ46Cyclin-dependent kinase 22.7.11.220.455
4fkr45KCyclin-dependent kinase 22.7.11.220.455
1gij2PUCyclin-dependent kinase 22.7.11.220.454
2c4g514Cyclin-dependent kinase 22.7.11.220.454
2w1hL0FCyclin-dependent kinase 22.7.11.220.454
3r1yX76Cyclin-dependent kinase 22.7.11.220.454
3rak03ZCyclin-dependent kinase 22.7.11.220.454
3rk507ZCyclin-dependent kinase 22.7.11.220.454
4eomATPCyclin-dependent kinase 22.7.11.220.454
2uzoC62Cyclin-dependent kinase 22.7.11.220.453
4erwSTUCyclin-dependent kinase 22.7.11.220.453
4fki09KCyclin-dependent kinase 22.7.11.220.453
1p2a5BNCyclin-dependent kinase 22.7.11.220.452
2a0cCK9Cyclin-dependent kinase 22.7.11.220.452
2c6lDT4Cyclin-dependent kinase 22.7.11.220.452
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.452
3r1qX75Cyclin-dependent kinase 22.7.11.220.452
3rni21ZCyclin-dependent kinase 22.7.11.220.452
3sqq99ZCyclin-dependent kinase 22.7.11.220.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
1fvt106Cyclin-dependent kinase 22.7.11.220.451
1pxkCK3Cyclin-dependent kinase 22.7.11.220.451
3qzfX66Cyclin-dependent kinase 22.7.11.220.451
3s1h56ZCyclin-dependent kinase 22.7.11.220.451
2b52D42Cyclin-dependent kinase 22.7.11.220.450
2vv9IM9Cyclin-dependent kinase 22.7.11.220.449
4btjATPTau-tubulin kinase 12.7.11.10.449
1ke8LS4Cyclin-dependent kinase 22.7.11.220.448
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.448
3ql8X01Cyclin-dependent kinase 22.7.11.220.448
1gih1PUCyclin-dependent kinase 22.7.11.220.447
2c68CT6Cyclin-dependent kinase 22.7.11.220.447
1gz8MBPCyclin-dependent kinase 22.7.11.220.446
3qtzX42Cyclin-dependent kinase 22.7.11.220.446
4uuxAPRCinA-like protein/0.446
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.445
3ezvEZVCyclin-dependent kinase 22.7.11.220.445
2iw94SPCyclin-dependent kinase 22.7.11.220.444
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.443
4bgh3I6Cyclin-dependent kinase 22.7.11.220.443
1urwI1PCyclin-dependent kinase 22.7.11.220.442
2b54D05Cyclin-dependent kinase 22.7.11.220.442
3dogNNNCyclin-dependent kinase 22.7.11.220.442
3uli1N3Cyclin-dependent kinase 22.7.11.220.442
3wblPDYCyclin-dependent kinase 22.7.11.220.442
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4eop1ROCyclin-dependent kinase 22.7.11.220.442
4bcmT7ZCyclin-dependent kinase 22.7.11.220.441
4bcpT3CCyclin-dependent kinase 22.7.11.220.441
1jstATPCyclin-dependent kinase 22.7.11.220.440
1oi9N20Cyclin-dependent kinase 22.7.11.220.440
2w05FRTCyclin-dependent kinase 22.7.11.220.440
3k5uPFQAurora kinase A2.7.11.10.440