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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3roy22ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3roy22ZCyclin-dependent kinase 22.7.11.221.000
3r6xX84Cyclin-dependent kinase 22.7.11.220.751
3r28XA0Cyclin-dependent kinase 22.7.11.220.741
3r1qX75Cyclin-dependent kinase 22.7.11.220.718
3qxoX65Cyclin-dependent kinase 22.7.11.220.699
3qu0X40Cyclin-dependent kinase 22.7.11.220.661
3qzhX69Cyclin-dependent kinase 22.7.11.220.660
3raiX85Cyclin-dependent kinase 22.7.11.220.656
3qwkX62Cyclin-dependent kinase 22.7.11.220.650
3qqfX07Cyclin-dependent kinase 22.7.11.220.649
1ckpPVBCyclin-dependent kinase 22.7.11.220.646
4lyn1YGCyclin-dependent kinase 22.7.11.220.645
1ke6LS2Cyclin-dependent kinase 22.7.11.220.642
4fki09KCyclin-dependent kinase 22.7.11.220.626
1v1k3FPCyclin-dependent kinase 22.7.11.220.625
2btrU73Cyclin-dependent kinase 22.7.11.220.622
3s2pPMUCyclin-dependent kinase 22.7.11.220.622
3r1sX73Cyclin-dependent kinase 22.7.11.220.618
1vyzN5BCyclin-dependent kinase 22.7.11.220.617
2r64740Cyclin-dependent kinase 22.7.11.220.617
3qwjX6ACyclin-dependent kinase 22.7.11.220.610
3r7vZ02Cyclin-dependent kinase 22.7.11.220.609
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.608
3sqq99ZCyclin-dependent kinase 22.7.11.220.608
1ke5LS1Cyclin-dependent kinase 22.7.11.220.607
3r73X87Cyclin-dependent kinase 22.7.11.220.607
3r7eX88Cyclin-dependent kinase 22.7.11.220.607
2btsU32Cyclin-dependent kinase 22.7.11.220.605
3r8lZ30Cyclin-dependent kinase 22.7.11.220.605
1oiqHDUCyclin-dependent kinase 22.7.11.220.604
3rm719ZCyclin-dependent kinase 22.7.11.220.604
4ek610KCyclin-dependent kinase 22.7.11.220.602
3lfnA27Cyclin-dependent kinase 22.7.11.220.600
1fvt106Cyclin-dependent kinase 22.7.11.220.597
1h0w207Cyclin-dependent kinase 22.7.11.220.596
3qtzX42Cyclin-dependent kinase 22.7.11.220.596
4fkq42KCyclin-dependent kinase 22.7.11.220.594
2c6o4SPCyclin-dependent kinase 22.7.11.220.593
1ke7LS3Cyclin-dependent kinase 22.7.11.220.591
2a0cCK9Cyclin-dependent kinase 22.7.11.220.590
3qqkX02Cyclin-dependent kinase 22.7.11.220.590
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.588
3iggEFQCyclin-dependent kinase 22.7.11.220.588
3rpv26ZCyclin-dependent kinase 22.7.11.220.588
3fz1B98Cyclin-dependent kinase 22.7.11.220.587
1ke9LS5Cyclin-dependent kinase 22.7.11.220.586
3s0o50ZCyclin-dependent kinase 22.7.11.220.586
1oitHDTCyclin-dependent kinase 22.7.11.220.585
2w06FRVCyclin-dependent kinase 22.7.11.220.585
3qx2X63Cyclin-dependent kinase 22.7.11.220.585
4fkpLS5Cyclin-dependent kinase 22.7.11.220.585
1oi9N20Cyclin-dependent kinase 22.7.11.220.584
1w0xOLOCyclin-dependent kinase 22.7.11.220.584
3r1yX76Cyclin-dependent kinase 22.7.11.220.584
4ez30S0Cyclin-dependent kinase 22.7.11.220.584
1ke8LS4Cyclin-dependent kinase 22.7.11.220.583
1oguST8Cyclin-dependent kinase 22.7.11.220.583
3ral04ZCyclin-dependent kinase 22.7.11.220.583
3rk909ZCyclin-dependent kinase 22.7.11.220.583
4fkr45KCyclin-dependent kinase 22.7.11.220.581
3ddqRRCCyclin-dependent kinase 22.7.11.220.580
1g5sI17Cyclin-dependent kinase 22.7.11.220.579
3ezvEZVCyclin-dependent kinase 22.7.11.220.579
3r9hZ67Cyclin-dependent kinase 22.7.11.220.577
3ig7EFPCyclin-dependent kinase 22.7.11.220.576
2iw94SPCyclin-dependent kinase 22.7.11.220.575
1p2a5BNCyclin-dependent kinase 22.7.11.220.574
3ddpRC8Cyclin-dependent kinase 22.7.11.220.574
3r71X86Cyclin-dependent kinase 22.7.11.220.574
3rni21ZCyclin-dependent kinase 22.7.11.220.574
1pxkCK3Cyclin-dependent kinase 22.7.11.220.573
1pxmCK5Cyclin-dependent kinase 22.7.11.220.573
3qtuX44Cyclin-dependent kinase 22.7.11.220.573
2b55D31Cyclin-dependent kinase 22.7.11.220.571
2uzoC62Cyclin-dependent kinase 22.7.11.220.570
1oiyN41Cyclin-dependent kinase 22.7.11.220.567
3rjc06ZCyclin-dependent kinase 22.7.11.220.567
3rkb12ZCyclin-dependent kinase 22.7.11.220.565
4fkj11KCyclin-dependent kinase 22.7.11.220.565
3rk708ZCyclin-dependent kinase 22.7.11.220.564
3sw418KCyclin-dependent kinase 22.7.11.220.563
1vyw292Cyclin-dependent kinase 22.7.11.220.562
1di8DTQCyclin-dependent kinase 22.7.11.220.561
1urwI1PCyclin-dependent kinase 22.7.11.220.561
2b52D42Cyclin-dependent kinase 22.7.11.220.561
1h1r6CPCyclin-dependent kinase 22.7.11.220.560
1h1s4SPCyclin-dependent kinase 22.7.11.220.560
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.560
3r7iX9ICyclin-dependent kinase 22.7.11.220.560
2r3lSCWCyclin-dependent kinase 22.7.11.220.559
4fkt48KCyclin-dependent kinase 22.7.11.220.559
1gih1PUCyclin-dependent kinase 22.7.11.220.557
2r3p3SCCyclin-dependent kinase 22.7.11.220.557
3r7uX96Cyclin-dependent kinase 22.7.11.220.557
4bcpT3CCyclin-dependent kinase 22.7.11.220.557
4eok4SPCyclin-dependent kinase 22.7.11.220.557
3rm618ZCyclin-dependent kinase 22.7.11.220.556
1w8cN69Cyclin-dependent kinase 22.7.11.220.555
3qzgX67Cyclin-dependent kinase 22.7.11.220.555
3s1h56ZCyclin-dependent kinase 22.7.11.220.555
3qruX19Cyclin-dependent kinase 22.7.11.220.554
2fvdLIACyclin-dependent kinase 22.7.11.220.553
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.553
2w05FRTCyclin-dependent kinase 22.7.11.220.553
2wpa889Cyclin-dependent kinase 22.7.11.220.553
4bcmT7ZCyclin-dependent kinase 22.7.11.220.553
4fkg4CKCyclin-dependent kinase 22.7.11.220.553
4eor4SPCyclin-dependent kinase 22.7.11.220.552
3qziX72Cyclin-dependent kinase 22.7.11.220.550
3lfsA07Cyclin-dependent kinase 22.7.11.220.549
2iw84SPCyclin-dependent kinase 22.7.11.220.547
3r9dX6BCyclin-dependent kinase 22.7.11.220.547
2vu3LZECyclin-dependent kinase 22.7.11.220.545
3ti1B49Cyclin-dependent kinase 22.7.11.220.545
4fx360KCyclin-dependent kinase 22.7.11.220.545
4eos1ROCyclin-dependent kinase 22.7.11.220.544
1finATPCyclin-dependent kinase 22.7.11.220.543
2i40BLZCyclin-dependent kinase 22.7.11.220.543
3rak03ZCyclin-dependent kinase 22.7.11.220.543
2duv371Cyclin-dependent kinase 22.7.11.220.542
1e9hINRCyclin-dependent kinase 22.7.11.220.541
2bhhRYUCyclin-dependent kinase 22.7.11.220.541
2c4g514Cyclin-dependent kinase 22.7.11.220.540
2r3iSCFCyclin-dependent kinase 22.7.11.220.540
3ezrEZRCyclin-dependent kinase 22.7.11.220.540
3rk507ZCyclin-dependent kinase 22.7.11.220.540
3tnwF18Cyclin-dependent kinase 22.7.11.220.539
3unk0BYCyclin-dependent kinase 22.7.11.220.538
2r3kSCQCyclin-dependent kinase 22.7.11.220.537
3ql8X01Cyclin-dependent kinase 22.7.11.220.537
2xmyCDKCyclin-dependent kinase 22.7.11.220.536
1r78FMDCyclin-dependent kinase 22.7.11.220.535
4bgh3I6Cyclin-dependent kinase 22.7.11.220.535
2a4lRRCCyclin-dependent kinase 22.7.11.220.534
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.534
2wxvWXVCyclin-dependent kinase 22.7.11.220.534
1e1xNW1Cyclin-dependent kinase 22.7.11.220.533
2vthLZ2Cyclin-dependent kinase 22.7.11.220.533
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.533
2vtsLZCCyclin-dependent kinase 22.7.11.220.532
1dm2HMDCyclin-dependent kinase 22.7.11.220.531
2j9mPY8Cyclin-dependent kinase 22.7.11.220.531
3my5RFZCyclin-dependent kinase 22.7.11.220.530
4kd11QKCyclin-dependent kinase 22.7.11.220.530
3rmf20ZCyclin-dependent kinase 22.7.11.220.529
1h1q2A6Cyclin-dependent kinase 22.7.11.220.528
3bhtMFRCyclin-dependent kinase 22.7.11.220.527
3qqlX03Cyclin-dependent kinase 22.7.11.220.527
4bcnT9NCyclin-dependent kinase 22.7.11.220.527
1pyePM1Cyclin-dependent kinase 22.7.11.220.526
1b39ATPCyclin-dependent kinase 22.7.11.220.525
3unj0BXCyclin-dependent kinase 22.7.11.220.525
4eon1ROCyclin-dependent kinase 22.7.11.220.525
2c6iDT1Cyclin-dependent kinase 22.7.11.220.524
3dogNNNCyclin-dependent kinase 22.7.11.220.524
3r9oZ71Cyclin-dependent kinase 22.7.11.220.524
4eol1ROCyclin-dependent kinase 22.7.11.220.524
4fkv61KCyclin-dependent kinase 22.7.11.220.524
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.523
2uznC96Cyclin-dependent kinase 22.7.11.220.523
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.523
2vv9IM9Cyclin-dependent kinase 22.7.11.220.523
1pxoCK7Cyclin-dependent kinase 22.7.11.220.522
4fkw62KCyclin-dependent kinase 22.7.11.220.521
4nj32KDCyclin-dependent kinase 22.7.11.220.520
5aniES4Cyclin-dependent kinase 22.7.11.220.520
3qxpX64Cyclin-dependent kinase 22.7.11.220.519
4fks46KCyclin-dependent kinase 22.7.11.220.519
3lfqA28Cyclin-dependent kinase 22.7.11.220.518
4bcoT6QCyclin-dependent kinase 22.7.11.220.518
4eomATPCyclin-dependent kinase 22.7.11.220.518
3pj8404Cyclin-dependent kinase 22.7.11.220.517
3pxyJWSCyclin-dependent kinase 22.7.11.220.517
3qzfX66Cyclin-dependent kinase 22.7.11.220.517
3r8zZ63Cyclin-dependent kinase 22.7.11.220.517
4cfnJYMCyclin-dependent kinase 22.7.11.220.517
2r3mSCXCyclin-dependent kinase 22.7.11.220.516
3qrtX14Cyclin-dependent kinase 22.7.11.220.516
4acm7YGCyclin-dependent kinase 22.7.11.220.516
2exmZIPCyclin-dependent kinase 22.7.11.220.515
2vttLZDCyclin-dependent kinase 22.7.11.220.514
3le62BZCyclin-dependent kinase 22.7.11.220.514
3rpy27ZCyclin-dependent kinase 22.7.11.220.514
3tiz3TICyclin-dependent kinase 22.7.11.220.514
3wblPDYCyclin-dependent kinase 22.7.11.220.514
2r3r6SCCyclin-dependent kinase 22.7.11.220.511
1b38ATPCyclin-dependent kinase 22.7.11.220.510
2c69CT8Cyclin-dependent kinase 22.7.11.220.510
3rahO1ZCyclin-dependent kinase 22.7.11.220.510
4fko20KCyclin-dependent kinase 22.7.11.220.510
1h1pCMGCyclin-dependent kinase 22.7.11.220.509
2r3gSC9Cyclin-dependent kinase 22.7.11.220.509
3qtrX36Cyclin-dependent kinase 22.7.11.220.509
3uli1N3Cyclin-dependent kinase 22.7.11.220.509
1gij2PUCyclin-dependent kinase 22.7.11.220.508
1h0vUN4Cyclin-dependent kinase 22.7.11.220.508
2r3o2SCCyclin-dependent kinase 22.7.11.220.508
3s00Z60Cyclin-dependent kinase 22.7.11.220.508
2c6mDT5Cyclin-dependent kinase 22.7.11.220.507
3qtqX35Cyclin-dependent kinase 22.7.11.220.507
1pxpCK8Cyclin-dependent kinase 22.7.11.220.506
3r8uZ31Cyclin-dependent kinase 22.7.11.220.506
3rzb02ZCyclin-dependent kinase 22.7.11.220.505
3qqhX0ACyclin-dependent kinase 22.7.11.220.502
1ykr628Cyclin-dependent kinase 22.7.11.220.501
2cchATPCyclin-dependent kinase 22.7.11.220.501
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.501
2w1hL0FCyclin-dependent kinase 22.7.11.220.501
3qtxX43Cyclin-dependent kinase 22.7.11.220.501
2x1nX1NCyclin-dependent kinase 22.7.11.220.500
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.499
4eoi1ROCyclin-dependent kinase 22.7.11.220.499
2wihP48Cyclin-dependent kinase 22.7.11.220.498
3qx4X4BCyclin-dependent kinase 22.7.11.220.498
3rpr25ZCyclin-dependent kinase 22.7.11.220.498
1oiuN76Cyclin-dependent kinase 22.7.11.220.495
2c5nCK8Cyclin-dependent kinase 22.7.11.220.495
2c6tDT5Cyclin-dependent kinase 22.7.11.220.495
3py0SU9Cyclin-dependent kinase 22.7.11.220.494
1pxlCK4Cyclin-dependent kinase 22.7.11.220.493
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.493
4qmpDKISerine/threonine-protein kinase 242.7.11.10.493
2c6lDT4Cyclin-dependent kinase 22.7.11.220.492
3qtwX3ACyclin-dependent kinase 22.7.11.220.492
1pkdUCNCyclin-dependent kinase 22.7.11.220.491
4bcqTJFCyclin-dependent kinase 22.7.11.220.491
4eop1ROCyclin-dependent kinase 22.7.11.220.491
2bheBRYCyclin-dependent kinase 22.7.11.220.489
2uzdC85Cyclin-dependent kinase 22.7.11.220.489
2r3jSCJCyclin-dependent kinase 22.7.11.220.488
2w17I19Cyclin-dependent kinase 22.7.11.220.487
2xnbY8LCyclin-dependent kinase 22.7.11.220.487
1fvv107Cyclin-dependent kinase 22.7.11.220.486
3r9nZ68Cyclin-dependent kinase 22.7.11.220.486
1unlRRCCyclin-dependent-like kinase 52.7.11.10.484
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.484
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.484
1gz8MBPCyclin-dependent kinase 22.7.11.220.483
2vtqLZACyclin-dependent kinase 22.7.11.220.483
4ii5ADPCyclin-dependent kinase 22.7.11.220.481
2b54D05Cyclin-dependent kinase 22.7.11.220.479
2uzlC94Cyclin-dependent kinase 22.7.11.220.479
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.477
1gy3ATPCyclin-dependent kinase 22.7.11.220.476
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.476
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.474
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.472
1e1vCMGCyclin-dependent kinase 22.7.11.220.469
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.468
2uzbC75Cyclin-dependent kinase 22.7.11.220.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.466
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4gmy0X5Tyrosine-protein kinase JAK2/0.466
2eufLQQCyclin-dependent kinase 62.7.11.220.465
2uzeC95Cyclin-dependent kinase 22.7.11.220.465
2wipP49Cyclin-dependent kinase 22.7.11.220.464
2b53D23Cyclin-dependent kinase 22.7.11.220.463
2r3fSC8Cyclin-dependent kinase 22.7.11.220.463
3gubGUBDeath-associated protein kinase 12.7.11.10.463
3qtsX46Cyclin-dependent kinase 22.7.11.220.463
3r8pZ46Cyclin-dependent kinase 22.7.11.220.463
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
2wotZZGTGF-beta receptor type-12.7.11.300.462
4dgo0JWCasein kinase II subunit alpha2.7.11.10.462
2bkzSBCCyclin-dependent kinase 22.7.11.220.461
2f2cAP9Cyclin-dependent kinase 62.7.11.220.460
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.460
2c5yMTWCyclin-dependent kinase 22.7.11.220.459
4ogrADNCyclin-dependent kinase 92.7.11.220.459
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.457
3ggfGVDSerine/threonine-protein kinase 26/0.457
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.455
4qmySTUSerine/threonine-protein kinase 242.7.11.10.455
1v0pPVBCell division control protein 2 homolog2.7.11.220.454
3lq5SLQCyclin-dependent kinase 92.7.11.220.454
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.454
1xjdSTUProtein kinase C theta type2.7.11.130.452
4ivb1J5Tyrosine-protein kinase JAK1/0.452
2r3q5SCCyclin-dependent kinase 22.7.11.220.451
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.450
1rw8580TGF-beta receptor type-12.7.11.300.449
3nup3NUCyclin-dependent kinase 62.7.11.220.449
5dt0SKEAurora kinase A2.7.11.10.449
3nux3NVCyclin-dependent kinase 62.7.11.220.448
4bchT7ZCyclin-dependent kinase 92.7.11.220.448
1v0oINRCell division control protein 2 homolog2.7.11.220.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.445
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.445
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
5dr6SKEAurora kinase A2.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2xikJ60Serine/threonine-protein kinase 252.7.11.10.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3t8oATPRhodopsin kinase/0.443
2xngA0HAurora kinase A2.7.11.10.442
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.442
3zep1NXTyrosine-protein kinase JAK32.7.10.20.442
4bgg844Activin receptor type-12.7.11.300.442
4ivd15TTyrosine-protein kinase JAK1/0.442
2j0m4STFocal adhesion kinase 12.7.10.20.441
2wouZZFTGF-beta receptor type-12.7.11.300.441
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.441
4e4m0NHTyrosine-protein kinase JAK2/0.441
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.441
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.440
1vjy460TGF-beta receptor type-12.7.11.300.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
3a60STURibosomal protein S6 kinase beta-12.7.11.10.440
3lltANPProtein serine/threonine kinase-1/0.440
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440
4jajXU1Aurora kinase A2.7.11.10.440