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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rlq3RQHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rlq3RQHeat shock protein HSP 90-alpha/1.000
3r4pFU7Heat shock protein HSP 90-alpha/0.726
3ekrPY9Heat shock protein HSP 90-alpha/0.606
4fcr0TMHeat shock protein HSP 90-alpha/0.603
1yszNECEndoplasmin/0.564
2fypRDEEndoplasmin/0.563
1u2oNECEndoplasmin/0.562
3rlr3RRHeat shock protein HSP 90-alpha/0.558
3hekBD0Heat shock protein HSP 90-alpha/0.553
4xc0ACPHeat shock cognate 90 kDa protein/0.543
1u0zRDCEndoplasmin/0.539
3r4nFU5Heat shock protein HSP 90-alpha/0.539
3k974CDHeat shock protein HSP 90-alpha/0.536
3k981RCHeat shock protein HSP 90-alpha/0.535
4bqjXKLHeat shock protein HSP 90-alpha/0.534
3ekoPYUHeat shock protein HSP 90-alpha/0.532
1qy8RDIEndoplasmin/0.530
2wepADPATP-dependent molecular chaperone HSP82/0.526
1yc14BCHeat shock protein HSP 90-alpha/0.524
2yegXQGHeat shock protein HSP 90-alpha/0.523
2gqpPA7Endoplasmin/0.520
2xabVHDHeat shock protein HSP 90-alpha/0.517
2xhrC0PHeat shock protein HSP 90-alpha/0.514
2qg0A94Heat shock protein HSP 90-alpha/0.511
2iwuNP5ATP-dependent molecular chaperone HSP82/0.507
2bz5AB4Heat shock protein HSP 90-alpha/0.505
2yefANPHeat shock protein HSP 90-alpha/0.505
2hchN5AEndoplasmin/0.503
2hg1N5OEndoplasmin/0.503
2xcmADPCytosolic heat shock protein 90/0.501
1am1ADPATP-dependent molecular chaperone HSP82/0.493
2bt0CT5Heat shock protein HSP 90-alpha/0.493
2xhtC0YHeat shock protein HSP 90-alpha/0.491
2gfdRDAEndoplasmin/0.490
1u0yPA7Endoplasmin/0.484
2wi6ZZ6Heat shock protein HSP 90-alpha/0.484
3hhu819Heat shock protein HSP 90-alpha/0.483
1yc34BCHeat shock protein HSP 90-alpha/0.482
4ce17FKATP-dependent molecular chaperone HSP82/0.482
1qy5NECEndoplasmin/0.479
2breKJ2ATP-dependent molecular chaperone HSP82/0.479
3whaWHAHeat shock protein HSP 90-alpha/0.479
1y4sADPChaperone protein HtpG/0.476
3t10ACPHeat shock protein HSP 90-alpha/0.476
2werRDCATP-dependent molecular chaperone HSP82/0.472
3b28B2XHeat shock protein HSP 90-alpha/0.471
3ft8MOJHeat shock protein HSP 90-alpha/0.471
3k99PFTHeat shock protein HSP 90-alpha/0.471
3t2sAGSHeat shock protein HSP 90-alpha/0.470
4xcjADPHeat shock cognate 90 kDa protein/0.468
1uyhPU0Heat shock protein HSP 90-alpha/0.465
2byi2DDHeat shock protein HSP 90-alpha/0.465
1byqADPHeat shock protein HSP 90-alpha/0.464
1uy7PU4Heat shock protein HSP 90-alpha/0.464
3hyz42CHeat shock protein HSP 90-alpha/0.464
4ipeANPTNF receptor-associated protein 1/0.464
4ce2BO5ATP-dependent molecular chaperone HSP82/0.460
1uy8PU5Heat shock protein HSP 90-alpha/0.459
1yc443PHeat shock protein HSP 90-alpha/0.459
2byh2D7Heat shock protein HSP 90-alpha/0.458
2h55DZ8Heat shock protein HSP 90-alpha/0.458
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.455
2xx213CATP-dependent molecular chaperone HSP82/0.454
1osfKOSHeat shock protein HSP 90-alpha/0.453
3vhaVHAHeat shock protein HSP 90-alpha/0.453
4eftEFTHeat shock protein HSP 90-alpha/0.451
1uyiPUZHeat shock protein HSP 90-alpha/0.449
2wi72KLHeat shock protein HSP 90-alpha/0.449
2wi5ZZ5Heat shock protein HSP 90-alpha/0.448
2yjxYJXHeat shock protein HSP 90-alpha/0.448
2yi5YI5Heat shock protein HSP 90-alpha/0.447
3t1kANPHeat shock protein HSP 90-alpha/0.447
1uymPU3Heat shock protein HSP 90-beta/0.446
1uyePU9Heat shock protein HSP 90-alpha/0.445
2xd6XD6ATP-dependent molecular chaperone HSP82/0.445
4f650S9Fibroblast growth factor receptor 1/0.445
4jqlVJ6Heat shock protein HSP 90-alpha/0.445