sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3rib	SAH	N-lysine methyltransferase SMYD2

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3rib	SAH	N-lysine methyltransferase SMYD2	/	1.000
3n71	SFG	Histone-lysine N-methyltransferase Smyd1	/	0.559
3pdn	SFG	Histone-lysine N-methyltransferase SMYD3	2.1.1.43	0.521
3ru0	SFG	Histone-lysine N-methyltransferase SMYD3	2.1.1.43	0.517
2h21	SAM	Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	2.1.1.127	0.479
1mlv	SAH	Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	2.1.1.127	0.464