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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3repATPIntegrin-linked protein kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3repATPIntegrin-linked protein kinase2.7.11.11.000
4zseANPEpidermal growth factor receptor2.7.10.10.505
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.500
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.495
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.492
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.491
2henADPEphrin type-B receptor 22.7.10.10.484
2qoqANPEphrin type-A receptor 32.7.10.10.484
1ir3ANPInsulin receptor2.7.10.10.481
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.480
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.479
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.479
4k33ACPFibroblast growth factor receptor 32.7.10.10.478
3vs3VSETyrosine-protein kinase HCK2.7.10.20.477
1u54ACPActivated CDC42 kinase 1/0.476
3clyACPFibroblast growth factor receptor 2/0.476
4j98ACPFibroblast growth factor receptor 2/0.476
4wkqIREEpidermal growth factor receptor2.7.10.10.476
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.475
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.475
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.475
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.474
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.473
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
5eg3ACPFibroblast growth factor receptor 2/0.472
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.470
1g4sTPSThiamine-phosphate synthase/0.469
2qo9ANPEphrin type-A receptor 32.7.10.10.469
2acxANPG protein-coupled receptor kinase 62.7.11.160.468
2pwlACPFibroblast growth factor receptor 2/0.468
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.468
4gu94GUFocal adhesion kinase 12.7.10.20.468
4zohFADPutative oxidoreductase FAD-binding subunit/0.468
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.467
3s1dZIRCytokinin dehydrogenase 11.5.99.120.467
1i44ACPInsulin receptor2.7.10.10.466
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
1v9aSAHUncharacterized protein/0.465
1aj8COACitrate synthase/0.464
1cm8ANPMitogen-activated protein kinase 12/0.464
2py3ACPFibroblast growth factor receptor 2/0.464
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.464
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4nks2M2Fibroblast growth factor receptor 1/0.464
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.463
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
2y9qANPMitogen-activated protein kinase 12.7.11.240.463
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.463
5e8xSTUTGF-beta receptor type-12.7.11.300.463
1nzdUPGDNA beta-glucosyltransferase/0.462
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1g28FMNPHY3/0.461
1j39UPGDNA beta-glucosyltransferase/0.461
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2ghmLICMitogen-activated protein kinase 14/0.461
2puiADPMethylthioribose kinase2.7.1.1000.461
2pz5ACPFibroblast growth factor receptor 2/0.461
4btjATPTau-tubulin kinase 12.7.11.10.461
4k8aK8AFocal adhesion kinase 12.7.10.20.461
1d7yFADFerredoxin reductase/0.460
1gebCAMCamphor 5-monooxygenase1.14.15.10.460
1ykdCMPAdenylate cyclase/0.460
2qo7ANPEphrin type-A receptor 32.7.10.10.460
3hmm855TGF-beta receptor type-12.7.11.300.460
3oriAGSSerine/threonine protein kinase/0.460
4gk3L87Ephrin type-A receptor 32.7.10.10.460
4jrnANPRhoptry kinase family protein/0.460
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.459
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.459
4tmcFMNOld yellow enzyme/0.459
4ysjADPCalmodulin-like domain protein kinase/0.459
1g4tFTPThiamine-phosphate synthase/0.458
1nhhANPDNA mismatch repair protein MutL/0.458
2itzIREEpidermal growth factor receptor2.7.10.10.458
3ormAGSSerine/threonine protein kinase/0.458
3q5iANPProtein kinase, putative/0.458
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3qyw6PBMitogen-activated protein kinase 12.7.11.240.458
3ttjJBIMitogen-activated protein kinase 102.7.11.240.458
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.457
1yw2PGJMitogen-activated protein kinase 14/0.457
3ge1ADPGlycerol kinase/0.457
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.457
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
1ewyFADFerredoxin--NADP reductase1.18.1.20.456
1g6cIFPThiamine-phosphate synthase/0.456
4gmy0X5Tyrosine-protein kinase JAK2/0.456
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.455
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.455
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.455
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.455
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.455
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
5e92ANPTGF-beta receptor type-22.7.11.300.455
1wbvLI3Mitogen-activated protein kinase 14/0.454
3kvxFMYMitogen-activated protein kinase 102.7.11.240.454
3poz03PEpidermal growth factor receptor2.7.10.10.454
4ix5ANPUncharacterized protein/0.454
4qmlANPSerine/threonine-protein kinase 242.7.11.10.454
5e8ySTUTGF-beta receptor type-22.7.11.300.454
3ibqATPPyridoxal kinase/0.453
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.453
3w16P9JAurora kinase A2.7.11.10.453
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4g3rCAMCamphor 5-monooxygenase1.14.15.10.453
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.453
4riyADPEpidermal growth factor receptor2.7.10.10.453
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.452
4ccbOFGALK tyrosine kinase receptor2.7.10.10.452
4dcaADPAminoglycoside phosphotransferase/0.452
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
4oauADP2-5A-dependent ribonuclease3.1.260.452
5cp4CAMCamphor 5-monooxygenase1.14.15.10.452
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.451
1t87CAMCamphor 5-monooxygenase1.14.15.10.451
1t88CAMCamphor 5-monooxygenase1.14.15.10.451
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2csnCKICasein kinase I homolog 12.7.11.10.451
2izrBRKCasein kinase I isoform gamma-32.7.11.10.451
3ttiKBIMitogen-activated protein kinase 102.7.11.240.451
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.451
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.451
4ux9ANPMitogen-activated protein kinase 82.7.11.240.451
4z34ON7Lysophosphatidic acid receptor 1/0.451
1ao0ADPAmidophosphoribosyltransferase/0.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
2excJNKMitogen-activated protein kinase 102.7.11.240.450
2yn8STUEphrin type-B receptor 42.7.10.10.450
3c4wATPRhodopsin kinase/0.450
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.450
3ddw055Glycogen phosphorylase, liver form2.4.1.10.450
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.450
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.450
4a6nFADTetX family tetracycline inactivation enzyme/0.450
1yrdCAMCamphor 5-monooxygenase1.14.15.10.449
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3r1yX76Cyclin-dependent kinase 22.7.11.220.449
3u9eCOALmo1369 protein/0.449
4c58824Cyclin-G-associated kinase2.7.11.10.449
4ddhMS0Pantothenate synthetase6.3.2.10.449
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4zhqACPTubulin tyrosine ligase/0.449
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.448
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.448
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
2wouZZFTGF-beta receptor type-12.7.11.300.448
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.448
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.448
4j97ACPFibroblast growth factor receptor 2/0.448
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.448
1suoCPZCytochrome P450 2B41.14.14.10.447
1xkkFMMEpidermal growth factor receptor2.7.10.10.447
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.447
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.447
4g2rH1LProbable propionyl-CoA carboxylase beta chain 66.4.1.30.447
1gldADPGlycerol kinase/0.446
1lhwESMSex hormone-binding globulin/0.446
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.446
3dj4UD1Bifunctional protein GlmU/0.446
3fwiCAMCamphor 5-monooxygenase1.14.15.10.446
3kjm245Cytokinin dehydrogenase 11.5.99.120.446
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.446
3p62FMNPentaerythritol tetranitrate reductase/0.446
3plsANPMacrophage-stimulating protein receptor2.7.10.10.446
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4pl3ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
1i59ADPChemotaxis protein CheA2.7.13.30.445
2izsBRQCasein kinase I isoform gamma-32.7.11.10.445
2np8CC3Aurora kinase A2.7.11.10.445
2pzpACPFibroblast growth factor receptor 2/0.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.445
4btjADPTau-tubulin kinase 12.7.11.10.445
4eh60ONMitogen-activated protein kinase 14/0.445
4f9wLM4Mitogen-activated protein kinase 14/0.445
4nj32KDCyclin-dependent kinase 22.7.11.220.445
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.444
2c27ACOMycothiol acetyltransferase2.3.1.1890.444
2etm7PYFocal adhesion kinase 12.7.10.20.444
2oapANPType II secretion system protein (GspE-2)/0.444
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
3eem53VUncharacterized protein/0.444
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4fkg4CKCyclin-dependent kinase 22.7.11.220.444
5fwnNAPPutative dehydrogenase/0.444
1nzfUPGDNA beta-glucosyltransferase/0.443
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.443
1ol7ADPAurora kinase A2.7.11.10.443
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.443
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.443
2l84J28CREB-binding protein/0.443
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
3iggEFQCyclin-dependent kinase 22.7.11.220.443
3lqfNADGalactitol dehydrogenase/0.443
3qc9ADPRhodopsin kinase/0.443
3sptUD1Bifunctional protein GlmU/0.443
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.443
4gk4L90Ephrin type-A receptor 32.7.10.10.443
4j95ACPFibroblast growth factor receptor 2/0.443
1bwsNDPGDP-L-fucose synthase/0.442
1mx0ANPType 2 DNA topoisomerase 6 subunit B/0.442
1qmfKEFPenicillin-binding protein 2x/0.442
1ykr628Cyclin-dependent kinase 22.7.11.220.442
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.442
2bunFADAppA protein/0.442
3icsCOACoenzyme A disulfide reductase/0.442
3rm719ZCyclin-dependent kinase 22.7.11.220.442
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4bbe3O4Tyrosine-protein kinase JAK2/0.442
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.442
4jrvKJVEpidermal growth factor receptor2.7.10.10.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
1hzzNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1pmn984Mitogen-activated protein kinase 102.7.11.240.441
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.441
2c6eHPMAurora kinase A2.7.11.10.441
2pywADPMethylthioribose kinase2.7.1.1000.441
2v7a627Tyrosine-protein kinase ABL12.7.10.20.441
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3dd125DGlycogen phosphorylase, liver form2.4.1.10.441
3lfnA27Cyclin-dependent kinase 22.7.11.220.441
3livE16Protease/0.441
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3r7uX96Cyclin-dependent kinase 22.7.11.220.441
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.441
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
1h51FMNPentaerythritol tetranitrate reductase/0.440
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2pupADPMethylthioribose kinase2.7.1.1000.440
2qocANPEphrin type-A receptor 32.7.10.10.440
2y3rTRKTamL/0.440
2zdt46CMitogen-activated protein kinase 102.7.11.240.440
3p74FMNPentaerythritol tetranitrate reductase/0.440
3r7eX88Cyclin-dependent kinase 22.7.11.220.440
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.440
3w32W32Epidermal growth factor receptor2.7.10.10.440
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4gyiADPUncharacterized protein/0.440
4l4dCAMCamphor 5-monooxygenase1.14.15.10.440
4nka2K7Fibroblast growth factor receptor 1/0.440
5cshATPCasein kinase II subunit alpha2.7.11.10.440