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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rc7TLOSugar 3-ketoreductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3rc7TLOSugar 3-ketoreductase/1.000
3rc9TLOSugar 3-ketoreductase/0.477
1euyQSIGlutamine--tRNA ligase6.1.1.180.475
2rd2QSIGlutamine--tRNA ligase6.1.1.180.468
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.465
3kxoKXOHematopoietic prostaglandin D synthase/0.463
2vcxD26Hematopoietic prostaglandin D synthase/0.458
2q0gUPUPoly(A) polymerase, putative/0.456
4jyzATPGlutamine--tRNA ligase6.1.1.180.456
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
2re8GSUGlutamine--tRNA ligase6.1.1.180.453
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
1necFMNOxygen-insensitive NAD(P)H nitroreductase10.449
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.447
2oz57XYUncharacterized protein/0.447
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.446
3tdkUPGUDP-glucose 6-dehydrogenase1.1.1.220.445
3apwDP0Alpha-1-acid glycoprotein 2/0.444
2qw034Z4-chlorobenzoyl CoA ligase/0.443
3stdMQ0Scytalone dehydratase4.2.1.940.443
1kruIPTGalactoside O-acetyltransferase2.3.1.180.442
3ngq1PSCCR4-NOT transcription complex subunit 6-like3.1.13.40.441
1xmvADPProtein RecA/0.440
2wgs1AZGlutamine synthetase6.3.1.20.440