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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ral04ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ral04ZCyclin-dependent kinase 22.7.11.221.000
3rak03ZCyclin-dependent kinase 22.7.11.220.749
3s1h56ZCyclin-dependent kinase 22.7.11.220.727
3rmf20ZCyclin-dependent kinase 22.7.11.220.707
3rpy27ZCyclin-dependent kinase 22.7.11.220.682
3sqq99ZCyclin-dependent kinase 22.7.11.220.635
3sw418KCyclin-dependent kinase 22.7.11.220.617
3r9dX6BCyclin-dependent kinase 22.7.11.220.609
2w06FRVCyclin-dependent kinase 22.7.11.220.608
3rk708ZCyclin-dependent kinase 22.7.11.220.606
3qtxX43Cyclin-dependent kinase 22.7.11.220.597
3rk507ZCyclin-dependent kinase 22.7.11.220.595
3qtzX42Cyclin-dependent kinase 22.7.11.220.591
2uznC96Cyclin-dependent kinase 22.7.11.220.590
3rpv26ZCyclin-dependent kinase 22.7.11.220.588
3qqkX02Cyclin-dependent kinase 22.7.11.220.585
3rjc06ZCyclin-dependent kinase 22.7.11.220.582
3qtrX36Cyclin-dependent kinase 22.7.11.220.580
4fkj11KCyclin-dependent kinase 22.7.11.220.580
3qzgX67Cyclin-dependent kinase 22.7.11.220.579
2r3lSCWCyclin-dependent kinase 22.7.11.220.574
1gih1PUCyclin-dependent kinase 22.7.11.220.573
1p2a5BNCyclin-dependent kinase 22.7.11.220.573
1urwI1PCyclin-dependent kinase 22.7.11.220.573
3qu0X40Cyclin-dependent kinase 22.7.11.220.572
3qxoX65Cyclin-dependent kinase 22.7.11.220.572
3qxpX64Cyclin-dependent kinase 22.7.11.220.572
4fkr45KCyclin-dependent kinase 22.7.11.220.572
4fkw62KCyclin-dependent kinase 22.7.11.220.571
4fkv61KCyclin-dependent kinase 22.7.11.220.569
2r3p3SCCyclin-dependent kinase 22.7.11.220.567
2xmyCDKCyclin-dependent kinase 22.7.11.220.567
3s0o50ZCyclin-dependent kinase 22.7.11.220.567
4acm7YGCyclin-dependent kinase 22.7.11.220.566
3rni21ZCyclin-dependent kinase 22.7.11.220.564
1fvt106Cyclin-dependent kinase 22.7.11.220.563
1v1k3FPCyclin-dependent kinase 22.7.11.220.563
1y91CT9Cyclin-dependent kinase 22.7.11.220.563
1oiyN41Cyclin-dependent kinase 22.7.11.220.562
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.562
4bgh3I6Cyclin-dependent kinase 22.7.11.220.562
4fx360KCyclin-dependent kinase 22.7.11.220.561
3r1sX73Cyclin-dependent kinase 22.7.11.220.560
2btsU32Cyclin-dependent kinase 22.7.11.220.559
3ezvEZVCyclin-dependent kinase 22.7.11.220.559
1oi9N20Cyclin-dependent kinase 22.7.11.220.557
3unk0BYCyclin-dependent kinase 22.7.11.220.557
1ke5LS1Cyclin-dependent kinase 22.7.11.220.556
1w0xOLOCyclin-dependent kinase 22.7.11.220.556
3r71X86Cyclin-dependent kinase 22.7.11.220.554
4fko20KCyclin-dependent kinase 22.7.11.220.554
4fkt48KCyclin-dependent kinase 22.7.11.220.554
1ke9LS5Cyclin-dependent kinase 22.7.11.220.553
2r3kSCQCyclin-dependent kinase 22.7.11.220.553
4fkg4CKCyclin-dependent kinase 22.7.11.220.553
3py0SU9Cyclin-dependent kinase 22.7.11.220.552
3ti1B49Cyclin-dependent kinase 22.7.11.220.552
3uli1N3Cyclin-dependent kinase 22.7.11.220.552
3r9hZ67Cyclin-dependent kinase 22.7.11.220.551
3sw719KCyclin-dependent kinase 22.7.11.220.551
4ez30S0Cyclin-dependent kinase 22.7.11.220.551
2b52D42Cyclin-dependent kinase 22.7.11.220.549
3roy22ZCyclin-dependent kinase 22.7.11.220.549
1aq1STUCyclin-dependent kinase 22.7.11.220.548
1oitHDTCyclin-dependent kinase 22.7.11.220.548
2iw84SPCyclin-dependent kinase 22.7.11.220.547
3r73X87Cyclin-dependent kinase 22.7.11.220.547
2c6iDT1Cyclin-dependent kinase 22.7.11.220.546
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.546
2w17I19Cyclin-dependent kinase 22.7.11.220.546
4ek610KCyclin-dependent kinase 22.7.11.220.546
2a0cCK9Cyclin-dependent kinase 22.7.11.220.545
4fkq42KCyclin-dependent kinase 22.7.11.220.545
2r64740Cyclin-dependent kinase 22.7.11.220.544
3ql8X01Cyclin-dependent kinase 22.7.11.220.544
3r7uX96Cyclin-dependent kinase 22.7.11.220.544
3qruX19Cyclin-dependent kinase 22.7.11.220.542
2c6o4SPCyclin-dependent kinase 22.7.11.220.541
3r7iX9ICyclin-dependent kinase 22.7.11.220.540
1ke6LS2Cyclin-dependent kinase 22.7.11.220.539
3qzhX69Cyclin-dependent kinase 22.7.11.220.539
1fvv107Cyclin-dependent kinase 22.7.11.220.538
2btrU73Cyclin-dependent kinase 22.7.11.220.538
3r9oZ71Cyclin-dependent kinase 22.7.11.220.537
3qqfX07Cyclin-dependent kinase 22.7.11.220.536
3qtuX44Cyclin-dependent kinase 22.7.11.220.536
2bhhRYUCyclin-dependent kinase 22.7.11.220.535
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.535
3fz1B98Cyclin-dependent kinase 22.7.11.220.535
3lfnA27Cyclin-dependent kinase 22.7.11.220.535
3r8zZ63Cyclin-dependent kinase 22.7.11.220.535
1pkdUCNCyclin-dependent kinase 22.7.11.220.534
1pxmCK5Cyclin-dependent kinase 22.7.11.220.534
1ke7LS3Cyclin-dependent kinase 22.7.11.220.533
2wxvWXVCyclin-dependent kinase 22.7.11.220.532
3qtqX35Cyclin-dependent kinase 22.7.11.220.532
1dm2HMDCyclin-dependent kinase 22.7.11.220.531
1g5sI17Cyclin-dependent kinase 22.7.11.220.531
3qtwX3ACyclin-dependent kinase 22.7.11.220.531
3unj0BXCyclin-dependent kinase 22.7.11.220.530
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.529
1e9hINRCyclin-dependent kinase 22.7.11.220.528
1oirHDYCyclin-dependent kinase 22.7.11.220.528
1oguST8Cyclin-dependent kinase 22.7.11.220.527
2vthLZ2Cyclin-dependent kinase 22.7.11.220.527
4eok4SPCyclin-dependent kinase 22.7.11.220.527
1ke8LS4Cyclin-dependent kinase 22.7.11.220.526
2w1hL0FCyclin-dependent kinase 22.7.11.220.526
1pxoCK7Cyclin-dependent kinase 22.7.11.220.524
2uzoC62Cyclin-dependent kinase 22.7.11.220.524
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.523
3tnwF18Cyclin-dependent kinase 22.7.11.220.523
1h1r6CPCyclin-dependent kinase 22.7.11.220.522
1h1s4SPCyclin-dependent kinase 22.7.11.220.522
1vyzN5BCyclin-dependent kinase 22.7.11.220.522
3s2pPMUCyclin-dependent kinase 22.7.11.220.522
1di8DTQCyclin-dependent kinase 22.7.11.220.521
2vv9IM9Cyclin-dependent kinase 22.7.11.220.520
3rk909ZCyclin-dependent kinase 22.7.11.220.519
3rm719ZCyclin-dependent kinase 22.7.11.220.519
1vyw292Cyclin-dependent kinase 22.7.11.220.518
3r6xX84Cyclin-dependent kinase 22.7.11.220.518
3r8lZ30Cyclin-dependent kinase 22.7.11.220.518
4qmpDKISerine/threonine-protein kinase 242.7.11.10.518
3pxyJWSCyclin-dependent kinase 22.7.11.220.516
3rkb12ZCyclin-dependent kinase 22.7.11.220.515
4fki09KCyclin-dependent kinase 22.7.11.220.515
2wihP48Cyclin-dependent kinase 22.7.11.220.514
1gii1PUCyclin-dependent kinase 22.7.11.220.513
1ykr628Cyclin-dependent kinase 22.7.11.220.513
3ddpRC8Cyclin-dependent kinase 22.7.11.220.513
3ddqRRCCyclin-dependent kinase 22.7.11.220.513
2bheBRYCyclin-dependent kinase 22.7.11.220.512
1pxpCK8Cyclin-dependent kinase 22.7.11.220.511
2b55D31Cyclin-dependent kinase 22.7.11.220.511
2fvdLIACyclin-dependent kinase 22.7.11.220.511
2vttLZDCyclin-dependent kinase 22.7.11.220.511
3ig7EFPCyclin-dependent kinase 22.7.11.220.511
4fkpLS5Cyclin-dependent kinase 22.7.11.220.511
2iw94SPCyclin-dependent kinase 22.7.11.220.510
4ek816KCyclin-dependent kinase 22.7.11.220.509
2i40BLZCyclin-dependent kinase 22.7.11.220.508
4lyn1YGCyclin-dependent kinase 22.7.11.220.508
3qzfX66Cyclin-dependent kinase 22.7.11.220.507
3raiX85Cyclin-dependent kinase 22.7.11.220.507
1h0w207Cyclin-dependent kinase 22.7.11.220.506
2wpa889Cyclin-dependent kinase 22.7.11.220.506
2j9mPY8Cyclin-dependent kinase 22.7.11.220.505
2w05FRTCyclin-dependent kinase 22.7.11.220.505
1oiqHDUCyclin-dependent kinase 22.7.11.220.504
3iggEFQCyclin-dependent kinase 22.7.11.220.504
2xnbY8LCyclin-dependent kinase 22.7.11.220.503
4fks46KCyclin-dependent kinase 22.7.11.220.502
3qqhX0ACyclin-dependent kinase 22.7.11.220.500
4eomATPCyclin-dependent kinase 22.7.11.220.500
4eol1ROCyclin-dependent kinase 22.7.11.220.499
1ckpPVBCyclin-dependent kinase 22.7.11.220.498
2r3o2SCCyclin-dependent kinase 22.7.11.220.498
1pyePM1Cyclin-dependent kinase 22.7.11.220.497
2cchATPCyclin-dependent kinase 22.7.11.220.497
2pvnP63Casein kinase II subunit alpha2.7.11.10.496
3qwkX62Cyclin-dependent kinase 22.7.11.220.496
3rzb02ZCyclin-dependent kinase 22.7.11.220.496
1r78FMDCyclin-dependent kinase 22.7.11.220.494
2vtsLZCCyclin-dependent kinase 22.7.11.220.494
3r8pZ46Cyclin-dependent kinase 22.7.11.220.494
4nj32KDCyclin-dependent kinase 22.7.11.220.493
3r1qX75Cyclin-dependent kinase 22.7.11.220.492
4bcnT9NCyclin-dependent kinase 22.7.11.220.492
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.492
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.491
4dgo0JWCasein kinase II subunit alpha2.7.11.10.491
1gij2PUCyclin-dependent kinase 22.7.11.220.490
3lfsA07Cyclin-dependent kinase 22.7.11.220.490
3rpo24ZCyclin-dependent kinase 22.7.11.220.490
2duv371Cyclin-dependent kinase 22.7.11.220.489
2c5nCK8Cyclin-dependent kinase 22.7.11.220.488
2c6tDT5Cyclin-dependent kinase 22.7.11.220.488
3lfqA28Cyclin-dependent kinase 22.7.11.220.488
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.488
2vu3LZECyclin-dependent kinase 22.7.11.220.487
1finATPCyclin-dependent kinase 22.7.11.220.486
2x1nX1NCyclin-dependent kinase 22.7.11.220.485
3r7vZ02Cyclin-dependent kinase 22.7.11.220.485
4ii5ADPCyclin-dependent kinase 22.7.11.220.485
3bhtMFRCyclin-dependent kinase 22.7.11.220.484
2uzlC94Cyclin-dependent kinase 22.7.11.220.482
3qwjX6ACyclin-dependent kinase 22.7.11.220.482
3rm618ZCyclin-dependent kinase 22.7.11.220.482
3pj8404Cyclin-dependent kinase 22.7.11.220.481
4bcpT3CCyclin-dependent kinase 22.7.11.220.481
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.481
2a4lRRCCyclin-dependent kinase 22.7.11.220.480
2r3fSC8Cyclin-dependent kinase 22.7.11.220.480
3wblPDYCyclin-dependent kinase 22.7.11.220.480
4eor4SPCyclin-dependent kinase 22.7.11.220.480
4eoi1ROCyclin-dependent kinase 22.7.11.220.479
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.479
3dogNNNCyclin-dependent kinase 22.7.11.220.478
3r7yZ04Cyclin-dependent kinase 22.7.11.220.478
1pxkCK3Cyclin-dependent kinase 22.7.11.220.477
2r3iSCFCyclin-dependent kinase 22.7.11.220.477
3r7eX88Cyclin-dependent kinase 22.7.11.220.477
1h1pCMGCyclin-dependent kinase 22.7.11.220.476
2uzeC95Cyclin-dependent kinase 22.7.11.220.476
3r28XA0Cyclin-dependent kinase 22.7.11.220.476
2r3r6SCCyclin-dependent kinase 22.7.11.220.475
4eos1ROCyclin-dependent kinase 22.7.11.220.474
3qx2X63Cyclin-dependent kinase 22.7.11.220.473
4kd11QKCyclin-dependent kinase 22.7.11.220.473
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.472
3my5RFZCyclin-dependent kinase 22.7.11.220.472
3qrtX14Cyclin-dependent kinase 22.7.11.220.472
4bcmT7ZCyclin-dependent kinase 22.7.11.220.472
2uzbC75Cyclin-dependent kinase 22.7.11.220.471
4btjATPTau-tubulin kinase 12.7.11.10.471
2c6kDT2Cyclin-dependent kinase 22.7.11.220.470
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.470
4eop1ROCyclin-dependent kinase 22.7.11.220.470
2eufLQQCyclin-dependent kinase 62.7.11.220.469
1oiuN76Cyclin-dependent kinase 22.7.11.220.468
2c6lDT4Cyclin-dependent kinase 22.7.11.220.468
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.467
3r83Z14Cyclin-dependent kinase 22.7.11.220.467
1e1xNW1Cyclin-dependent kinase 22.7.11.220.466
2c6mDT5Cyclin-dependent kinase 22.7.11.220.466
3tiz3TICyclin-dependent kinase 22.7.11.220.466
2c69CT8Cyclin-dependent kinase 22.7.11.220.465
3gubGUBDeath-associated protein kinase 12.7.11.10.465
2r3mSCXCyclin-dependent kinase 22.7.11.220.464
3axwTIDCasein kinase II subunit alpha2.7.11.10.463
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.462
1v0oINRCell division control protein 2 homolog2.7.11.220.462
2c5yMTWCyclin-dependent kinase 22.7.11.220.462
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.462
2bkzSBCCyclin-dependent kinase 22.7.11.220.461
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.460
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.460
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.459
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.459
4aua4AUCyclin-dependent kinase 62.7.11.220.459
1unlRRCCyclin-dependent-like kinase 52.7.11.10.458
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.458
4dgmAGICasein kinase II subunit alpha2.7.11.10.458
4eon1ROCyclin-dependent kinase 22.7.11.220.458
4gmy0X5Tyrosine-protein kinase JAK2/0.458
3gu6ADPDeath-associated protein kinase 12.7.11.10.457
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.457
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.457
1xjdSTUProtein kinase C theta type2.7.11.130.456
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.456
1vjy460TGF-beta receptor type-12.7.11.300.455
1h1q2A6Cyclin-dependent kinase 22.7.11.220.454
3gxlQIGTGF-beta receptor type-12.7.11.300.454
3zh8C58Protein kinase C iota type2.7.11.130.454
4anmWULCasein kinase II subunit alpha2.7.11.10.454
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.454
1y8yCT7Cyclin-dependent kinase 22.7.11.220.453
3qqlX03Cyclin-dependent kinase 22.7.11.220.453
3r1yX76Cyclin-dependent kinase 22.7.11.220.453
4dgnLU2Casein kinase II subunit alpha2.7.11.10.453
1gy3ATPCyclin-dependent kinase 22.7.11.220.452
4eooATPCyclin-dependent kinase 22.7.11.220.452
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.452
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.452
1b38ATPCyclin-dependent kinase 22.7.11.220.451
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.451
5e8wSTUTGF-beta receptor type-12.7.11.300.451
3qziX72Cyclin-dependent kinase 22.7.11.220.450
3r9nZ68Cyclin-dependent kinase 22.7.11.220.450
3rahO1ZCyclin-dependent kinase 22.7.11.220.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.450
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.449
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.449
3bheBZNGag-Pol polyprotein3.4.23.160.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
4qmySTUSerine/threonine-protein kinase 242.7.11.10.449
2c4g514Cyclin-dependent kinase 22.7.11.220.448
2r3gSC9Cyclin-dependent kinase 22.7.11.220.448
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
2wipP49Cyclin-dependent kinase 22.7.11.220.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.448
1b39ATPCyclin-dependent kinase 22.7.11.220.447
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.447
3ggfGVDSerine/threonine-protein kinase 26/0.447
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
4qmzB49Serine/threonine-protein kinase 242.7.11.10.447
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bcqTJFCyclin-dependent kinase 22.7.11.220.446
5av4GENDeath-associated protein kinase 12.7.11.10.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
2uzdC85Cyclin-dependent kinase 22.7.11.220.445
2xikJ60Serine/threonine-protein kinase 252.7.11.10.445
4ivb1J5Tyrosine-protein kinase JAK1/0.445
1unhIXMCyclin-dependent-like kinase 52.7.11.10.444
2zjwREFCasein kinase II subunit alpha2.7.11.10.444
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.444
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.441
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
3r8uZ31Cyclin-dependent kinase 22.7.11.220.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.441
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.440
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
5auwQUEDeath-associated protein kinase 12.7.11.10.440