sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3r33	6ME	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3r33	6ME	Dihydrofolate reductase	1.5.1.3	1.000
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.462
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.460
3ia4	MTX	Dihydrofolate reductase	/	0.455
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
2w3v	TOP	Dihydrofolate reductase	/	0.452
3eem	53V	Uncharacterized protein	/	0.451
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.450
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.448
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.443
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.443
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.443
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.440