sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qto | 10P | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3qto | 10P | Prothrombin | 3.4.21.5 | 1.000 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.870 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.806 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.800 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.769 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.764 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.758 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.756 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.747 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.734 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.732 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.718 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.701 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.700 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.696 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.688 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.683 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.681 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.680 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.670 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.670 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.670 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.666 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.661 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.658 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.657 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.657 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.654 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.654 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.654 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.651 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.650 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.649 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.646 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.639 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.638 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.637 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.636 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.624 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.620 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.618 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.617 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.615 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.615 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.611 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.606 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.605 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.604 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.602 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.599 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.598 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.596 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.594 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.594 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.593 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.590 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.589 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.589 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.588 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.588 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.588 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.586 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.584 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.583 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.582 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.581 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.577 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.575 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.573 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.572 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.570 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.570 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.567 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.565 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.561 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.560 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.559 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.556 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.551 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.551 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.548 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.547 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.546 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.546 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.544 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.544 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.539 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.538 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.538 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.537 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.532 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.527 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.527 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.521 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.504 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.502 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.497 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.496 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.495 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.494 | |
| 3eks | CY9 | Actin-5C | / | 0.491 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.491 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.490 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.490 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.485 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.484 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.483 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.479 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.479 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.475 | |
| 3s7b | NH5 | N-lysine methyltransferase SMYD2 | / | 0.475 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.471 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.470 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.469 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.469 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.468 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.467 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.467 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.465 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.465 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.465 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.465 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.465 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.465 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.465 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.464 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.464 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.464 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.462 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.462 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.462 | |
| 1fml | RTL | Retinol dehydratase | / | 0.461 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.460 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.460 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.460 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.459 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.459 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.459 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.459 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.459 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.459 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.459 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.459 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.458 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.458 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4l96 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.457 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.457 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.457 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.456 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.456 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.456 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.456 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.456 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.455 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.455 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.455 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.454 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.454 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.454 | |
| 4b0c | C9H | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.454 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.454 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.453 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.453 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.453 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.453 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.453 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.452 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2p2x | SAH | Diphthine synthase | / | 0.452 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.452 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3qvi | K95 | HAP protein | / | 0.452 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.452 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.451 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.451 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.451 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.451 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.451 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.450 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.450 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.450 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.450 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.450 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.449 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.449 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.449 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3eku | CY9 | Actin-5C | / | 0.449 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.449 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.448 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.448 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 2zts | ADP | Uncharacterized protein | / | 0.448 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.448 | |
| 4jxr | ACO | Acetyltransferase | / | 0.448 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.448 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.447 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.447 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.446 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.446 | |
| 2pci | SAH | Diphthine synthase | / | 0.446 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.446 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4die | C5P | Cytidylate kinase | / | 0.446 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.445 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.445 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.445 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.445 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.444 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.444 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.444 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.444 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.444 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.444 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3p0h | FSE | Putative tyrosyl-tRNA synthetase | / | 0.444 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.444 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.444 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.444 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.444 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.443 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.443 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.443 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2xvv | 9DN | Serum albumin | / | 0.442 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.442 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.442 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.442 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4e2b | FMN | Dehydrogenase | / | 0.442 | |
| 4gek | GEK | Carboxy-S-adenosyl-L-methionine synthase | / | 0.442 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.441 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.441 | |
| 2ej2 | PPE | Branched-chain amino acid aminotransferase (IlvE) | / | 0.441 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.441 | |
| 3ipk | PMS | Surface protein adhesin | / | 0.441 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.441 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.441 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4h6p | FMN | Chromate reductase | / | 0.441 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1flm | FMN | FMN-binding protein | / | 0.440 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.440 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.440 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.440 | |
| 2r5n | TPP | Transketolase 1 | / | 0.440 | |
| 2r8o | T5X | Transketolase 1 | / | 0.440 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.440 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.440 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.440 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.440 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.440 | |
| 4h57 | 0PJ | Thermolysin | 3.4.24.27 | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 |