sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3qow	SAM	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3qow	SAM	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43	1.000
3sr4	TT8	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43	0.608
1nw3	SAM	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43	0.605
2eg5	SAH	7-methylxanthosine synthase 1	/	0.467
4ekg	0QJ	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43	0.465
4eki	0QK	Histone-lysine N-methyltransferase, H3 lysine-79 specific	2.1.1.43	0.457
2wvl	GDD	Mannosyl-3-phosphogylcerate synthase	/	0.441