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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qlrQLRDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3qlrQLRDihydrofolate reductase1.5.1.31.000
3qls55VDihydrofolate reductase1.5.1.30.651
1m78CLZDihydrofolate reductase1.5.1.30.649
1ia1TQ3Dihydrofolate reductase1.5.1.30.647
1aoeGW3Dihydrofolate reductase1.5.1.30.642
4h9614QDihydrofolate reductase1.5.1.30.640
4h9753SDihydrofolate reductase1.5.1.30.614
3qlwN22Dihydrofolate reductase1.5.1.30.613
3qly55VUncharacterized protein/0.605
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.604
3eek53SUncharacterized protein/0.602
1m7aMQUDihydrofolate reductase1.5.1.30.600
3cseN22Uncharacterized protein/0.600
3qlxQLRUncharacterized protein/0.596
4ixeIXEDihydrofolate reductase1.5.1.30.596
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.594
1m79MQ1Dihydrofolate reductase1.5.1.30.593
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.588
1ia2TQ4Dihydrofolate reductase1.5.1.30.585
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.584
2fziDH3Dihydrofolate reductase1.5.1.30.583
3qlsNDPDihydrofolate reductase1.5.1.30.583
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.582
3eem53VUncharacterized protein/0.579
3qlrNDPDihydrofolate reductase1.5.1.30.576
1ai9NDPDihydrofolate reductase1.5.1.30.575
1ia4TQ6Dihydrofolate reductase1.5.1.30.574
3eej53RUncharacterized protein/0.573
4h9506UDihydrofolate reductase1.5.1.30.572
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.571
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.569
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.569
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.568
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.567
3eel53TUncharacterized protein/0.566
4h9814QUncharacterized protein/0.565
1klkPMDDihydrofolate reductase1.5.1.30.562
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.558
3qlzQLZUncharacterized protein/0.558
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.557
4ixfIXFDihydrofolate reductase1.5.1.30.557
1dg5TOPDihydrofolate reductase1.5.1.30.554
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
1cd2FOLDihydrofolate reductase1.5.1.30.553
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.553
1ia3TQ5Dihydrofolate reductase1.5.1.30.552
3dfrMTXDihydrofolate reductase1.5.1.30.551
2cd2FOLDihydrofolate reductase1.5.1.30.549
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.546
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.546
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.545
1rx3MTXDihydrofolate reductase1.5.1.30.544
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.543
3td8D2RDihydrofolate reductase1.5.1.30.541
1vj3TABDihydrofolate reductase1.5.1.30.540
2w3vTOPDihydrofolate reductase/0.538
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.531
4ixgIXGDihydrofolate reductase1.5.1.30.529
2zzaFOLDihydrofolate reductase/0.528
1dajMOTDihydrofolate reductase1.5.1.30.527
4g8zTOPDihydrofolate reductase1.5.1.30.527
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.526
1hfqMOTDihydrofolate reductase1.5.1.30.525
4m2xTMQDihydrofolate reductase1.5.1.30.525
4xe606UDihydrofolate reductase1.5.1.30.525
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.523
3frdDHFDihydrofolate reductase1.5.1.30.521
3sh25DRDihydrofolate reductase1.5.1.30.521
2fzhDH1Dihydrofolate reductase1.5.1.30.520
3freTOPDihydrofolate reductase1.5.1.30.520
1dg7WRBDihydrofolate reductase1.5.1.30.518
1e26GPBDihydrofolate reductase1.5.1.30.517
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
3jwm5WBDihydrofolate reductase/0.516
3sa16DRDihydrofolate reductase/0.515
3cd2MTXDihydrofolate reductase1.5.1.30.514
3tq9MTXDihydrofolate reductase/0.514
4kbn25UDihydrofolate reductase1.5.1.30.513
1ddsMTXDihydrofolate reductase1.5.1.30.507
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.507
3jwcEKBDihydrofolate reductase/0.505
3koo24DBifunctional epoxide hydrolase 23.3.2.100.505
4fgg0U5Dihydrofolate reductase1.5.1.30.505
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.504
3fywXCFDihydrofolate reductase1.5.1.30.504
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.502
1og5SWFCytochrome P450 2C9/0.501
3fy9XCFDihydrofolate reductase1.5.1.30.501
3i8aN22Dihydrofolate reductase1.5.1.30.500
4fgh0U6Dihydrofolate reductase1.5.1.30.500
4kak06UDihydrofolate reductase1.5.1.30.500
4m6l21VDihydrofolate reductase1.5.1.30.500
3k47D09Dihydrofolate reductase1.5.1.30.499
1hfpMOTDihydrofolate reductase1.5.1.30.498
1ly3COGDihydrofolate reductase1.5.1.30.497
3tqbFOLDihydrofolate reductase/0.495
7dfrFOLDihydrofolate reductase1.5.1.30.495
1df7MTXDihydrofolate reductase1.5.1.30.493
3jw5TOPDihydrofolate reductase/0.493
3ia4MTXDihydrofolate reductase/0.492
1s3yTQTDihydrofolate reductase1.5.1.30.491
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.491
3sai9DRDihydrofolate reductase/0.491
1dg8NDPDihydrofolate reductase1.5.1.30.489
3frfXCFDihydrofolate reductase1.5.1.30.489
4nx6FOLDihydrofolate reductase1.5.1.30.489
3srqQ19Dihydrofolate reductase1.5.1.30.488
4kd79DRDihydrofolate reductase1.5.1.30.487
4x5gFOLDihydrofolate reductase1.5.1.30.487
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.486
4cd2FOLDihydrofolate reductase1.5.1.30.486
4kjjFOLDihydrofolate reductase1.5.1.30.486
1disBDMDihydrofolate reductase1.5.1.30.485
3fraI2HDihydrofolate reductase1.5.1.30.485
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.484
4kfj1R0Dihydrofolate reductase1.5.1.30.484
1fmjRTLRetinol dehydratase/0.482
2w3aTOPDihydrofolate reductase1.5.1.30.482
1draMTXDihydrofolate reductase1.5.1.30.481
3ql3FOLDihydrofolate reductase1.5.1.30.481
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.480
3sa27DRDihydrofolate reductase/0.480
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.479
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
3vt5YI2Vitamin D3 receptor/0.479
3oafOAGDihydrofolate reductase1.5.1.30.477
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.477
4fhf0TTSpore photoproduct lyase/0.477
4p66MTXDihydrofolate reductase/0.477
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.475
4nx7FOLDihydrofolate reductase1.5.1.30.475
3sgy06WDihydrofolate reductase1.5.1.30.474
3gwfNAPCyclohexanone monooxygenase/0.473
3nxvD2FDihydrofolate reductase1.5.1.30.473
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
4j6cSTRCytochrome P450 monooxygenase/0.472
4x5jFOLDihydrofolate reductase1.5.1.30.472
2zbaZBATrichothecene 3-O-acetyltransferase/0.470
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.470
3ad9NADSubunit alpha of sarocosine oxidase/0.469
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.469
3mg3ECHOrange carotenoid-binding protein/0.469
4x5fFOLDihydrofolate reductase1.5.1.30.469
1bozPRDDihydrofolate reductase1.5.1.30.468
3r336MEDihydrofolate reductase1.5.1.30.468
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.468
2w3wVG9Dihydrofolate reductase/0.467
3nj0PYVAbscisic acid receptor PYL2/0.467
1ek2CDUBifunctional epoxide hydrolase 2/0.466
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2w9gTOPDihydrofolate reductase1.5.1.30.466
3l3rOAGDihydrofolate reductase1.5.1.30.466
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.466
3bfa9ODOdorant binding protein ASP1/0.465
4ele31IDihydrofolate reductase/0.465
1m13HYFNuclear receptor subfamily 1 group I member 2/0.464
1rx1NAPDihydrofolate reductase1.5.1.30.464
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
3drcMTXDihydrofolate reductase1.5.1.30.464
3sqyQ11Dihydrofolate reductase1.5.1.30.464
1rx8FOLDihydrofolate reductase1.5.1.30.462
3adaNADSubunit alpha of sarocosine oxidase/0.462
3d84NDPDihydrofolate reductase1.5.1.30.462
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1dhjMTXDihydrofolate reductase1.5.1.30.461
3fy8XCFDihydrofolate reductase1.5.1.30.461
3kpzZNEVitamin D3 receptor/0.461
3nmpPYVAbscisic acid receptor PYL2/0.461
1dyiFOLDihydrofolate reductase1.5.1.30.460
3eigMTXDihydrofolate reductase1.5.1.30.460
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3srwQ27Dihydrofolate reductase1.5.1.30.460
1q5dEPBEpothilone C/D epoxidase1.140.459
1re7FOLDihydrofolate reductase1.5.1.30.459
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
4i1nFOLDihydrofolate reductase1.5.1.30.459
4kebFOLDihydrofolate reductase1.5.1.30.459
1dr3TAPDihydrofolate reductase1.5.1.30.458
1ly4COQDihydrofolate reductase1.5.1.30.458
1rc4DDFDihydrofolate reductase1.5.1.30.458
2zlcVDXVitamin D3 receptor/0.458
3lfcZ86Mitogen-activated protein kinase 14/0.458
3m08RARDihydrofolate reductase1.5.1.30.458
3mdmFJZCholesterol 24-hydroxylase/0.458
4cukNAID-lactate dehydrogenase/0.458
4ia1BIVVitamin D3 receptor A/0.458
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.458
5eccNAPDehydrofolate reductase type I/0.458
2uxhQUEHTH-type transcriptional regulator TtgR/0.457
2vbpVB1Isopenicillin N synthase1.21.3.10.457
3d80Q22Dihydrofolate reductase1.5.1.30.457
1cjkFOKAdenylate cyclase type 2/0.456
1cjkFOKAdenylate cyclase type 5/0.456
1ohjCOPDihydrofolate reductase1.5.1.30.456
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2vcmM11Isopenicillin N synthase1.21.3.10.456
3qyoQ24Dihydrofolate reductase1.5.1.30.456
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.456
4zasTYDCalS13/0.456
1jolFFODihydrofolate reductase1.5.1.30.455
3och2MXDihydrofolate reductase1.5.1.30.455
3srrQ20Dihydrofolate reductase1.5.1.30.455
4ia7BIVVitamin D3 receptor A/0.455
1hfrMOTDihydrofolate reductase1.5.1.30.454
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
4iui1GQEstrogen receptor/0.454
4m7vRARDihydrofolate reductase/0.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3ntz3TZDihydrofolate reductase1.5.1.30.453
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4ej1FOLDihydrofolate reductase1.5.1.30.453
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4kne1CYDihydrofolate reductase1.5.1.30.453
1d2sDHTSex hormone-binding globulin/0.452
1jomFFODihydrofolate reductase1.5.1.30.452
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.452
4dfrMTXDihydrofolate reductase1.5.1.30.452
4enhFVXCholesterol 24-hydroxylase/0.452
1ie9VDXVitamin D3 receptor/0.451
1rb3MTXDihydrofolate reductase1.5.1.30.451
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.451
3dauMTXDihydrofolate reductase1.5.1.30.451
3nglNAPBifunctional protein FolD/0.451
3tq8TOPDihydrofolate reductase/0.451
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.451
1ddrMTXDihydrofolate reductase1.5.1.30.450
2x7hPFNProstaglandin reductase 310.450
3fl8RARDihydrofolate reductase/0.450
4j6bPLOCytochrome P450 monooxygenase/0.450
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
4p68MTXDihydrofolate reductase/0.450
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
1kmsLIHDihydrofolate reductase1.5.1.30.449
1pkfEPDEpothilone C/D epoxidase1.140.449
1rx2FOLDihydrofolate reductase1.5.1.30.449
4iv21GREstrogen receptor/0.449
4j6dTESCytochrome P450 monooxygenase/0.449
1i58ACPChemotaxis protein CheA2.7.13.30.448
1pp9SMACytochrome b/0.448
1upw444Oxysterols receptor LXR-beta/0.448
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
3fyvXCFDihydrofolate reductase1.5.1.30.448
3gyf51PDihydrofolate reductase1.5.1.30.448
3h3r14HCollagen type IV alpha-3-binding protein/0.448
3vtcTK3Vitamin D3 receptor/0.448
3zoiM2WIsopenicillin N synthase1.21.3.10.448
4l0qNADAlcohol dehydrogenase class-3/0.448
4x5iFOLDihydrofolate reductase1.5.1.30.448
1dyrTOPDihydrofolate reductase1.5.1.30.447
1x8lOXRRetinol dehydratase/0.447
2acwUPGGlycosyltransferase/0.447
2fzjDH3Dihydrofolate reductase1.5.1.30.447
3gieACPSensor histidine kinase DesK2.7.13.30.447
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3qdd94MHeat shock protein HSP 90-alpha/0.447
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.447
1bzfTMQDihydrofolate reductase1.5.1.30.446
1tdrMTXDihydrofolate reductase1.5.1.30.446
2uxiG50HTH-type transcriptional regulator TtgR/0.446
2w3mFOLDihydrofolate reductase1.5.1.30.446
3ghwGHWDihydrofolate reductase1.5.1.30.446
4g1z0VPVitamin D3 receptor A/0.446
4ug71EVNitric oxide synthase oxygenase1.14.13.1650.446
1t85CAMCamphor 5-monooxygenase1.14.15.10.445
2hqpNDPDihydrofolate reductase1.5.1.30.445
2jfaRALEstrogen receptor/0.444
3qm4PN0Cytochrome P450 2D6/0.444
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3vt65YIVitamin D3 receptor/0.444
4g95OAGDihydrofolate reductase1.5.1.30.444
1rx6DDFDihydrofolate reductase1.5.1.30.443
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4l9q9TPSerum albumin/0.443
4ug7H4BNitric oxide synthase oxygenase1.14.13.1650.443
1kijNOVDNA gyrase subunit B/0.442
3hz142CHeat shock protein HSP 90-alpha/0.442
3inxJZCHeat shock protein HSP 90-alpha/0.442
3k1wBFXRenin3.4.23.150.442
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4i8vBHFCytochrome P450 1A11.14.14.10.442
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
1ohkCOPDihydrofolate reductase1.5.1.30.441
2rhrEMOPutative ketoacyl reductase1.3.10.441
3antS82Bifunctional epoxide hydrolase 23.3.2.100.441
3ertOHTEstrogen receptor/0.441
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.441
4fhbFOLDihydrofolate reductase1.5.1.30.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
2bxmIMNSerum albumin/0.440
2hcdBIVVitamin D3 receptor A/0.440
2lf1NDPDihydrofolate reductase1.5.1.30.440
2q9fC3SCholesterol 24-hydroxylase/0.440
2vbdV10Isopenicillin N synthase1.21.3.10.440
2yee2ECHeat shock protein HSP 90-alpha/0.440
3mdvCL6Cholesterol 24-hydroxylase/0.440
3srsM23Dihydrofolate reductase1.5.1.30.440