sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.651 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.649 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.647 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.642 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.640 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.614 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.613 | |
| 3qly | 55V | Uncharacterized protein | / | 0.605 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.604 | |
| 3eek | 53S | Uncharacterized protein | / | 0.602 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.600 | |
| 3cse | N22 | Uncharacterized protein | / | 0.600 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.596 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.594 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.593 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.588 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.585 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.584 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.582 | |
| 3eem | 53V | Uncharacterized protein | / | 0.579 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 3eej | 53R | Uncharacterized protein | / | 0.573 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.571 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.569 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.569 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.568 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.567 | |
| 3eel | 53T | Uncharacterized protein | / | 0.566 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.565 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.558 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.558 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.557 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.554 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.553 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.546 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.546 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.543 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.538 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.531 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.528 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.526 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.516 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.516 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.515 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.514 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.507 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.505 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.505 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.504 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.502 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.501 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.495 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.493 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.492 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.491 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.491 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.486 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.484 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.482 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.480 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.480 | |
| 1j3j | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.479 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.479 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.477 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.477 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.477 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.473 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.472 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.470 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.470 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.469 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.469 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.468 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.467 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.466 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.465 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.465 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.464 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.462 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.461 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.459 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.458 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.458 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.458 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.458 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.456 | |
| 4zas | TYD | CalS13 | / | 0.456 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.454 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.454 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.452 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.451 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.451 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.451 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.450 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.450 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.450 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.450 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.449 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.449 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.448 | |
| 1pp9 | SMA | Cytochrome b | / | 0.448 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.448 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2acw | UPG | Glycosyltransferase | / | 0.447 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.447 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.447 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2uxi | G50 | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4ug7 | 1EV | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.446 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2jfa | RAL | Estrogen receptor | / | 0.444 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4l9q | 9TP | Serum albumin | / | 0.443 | |
| 4ug7 | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.443 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.442 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.442 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.442 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.441 | |
| 3ert | OHT | Estrogen receptor | / | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2lf1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.440 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.440 |