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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.629
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.611
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.599
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.570
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.566
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.562
4f640S8Fibroblast growth factor receptor 1/0.558
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.554
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.552
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.547
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.547
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.547
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.547
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.541
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.537
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.536
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.534
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.534
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.533
1m17AQ4Epidermal growth factor receptor2.7.10.10.532
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.531
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.530
2pwlACPFibroblast growth factor receptor 2/0.529
4j97ACPFibroblast growth factor receptor 2/0.528
4nks2M2Fibroblast growth factor receptor 1/0.527
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.526
3vs3VSETyrosine-protein kinase HCK2.7.10.20.526
3js2VM1Fibroblast growth factor receptor 1/0.522
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.521
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.520
4nka2K7Fibroblast growth factor receptor 1/0.520
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.519
2hk51BMTyrosine-protein kinase HCK2.7.10.20.517
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.517
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.516
2of4979Tyrosine-protein kinase Lck2.7.10.20.512
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.512
3vjoANPEpidermal growth factor receptor2.7.10.10.511
3w2sW2REpidermal growth factor receptor2.7.10.10.510
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.509
2of2547Tyrosine-protein kinase Lck2.7.10.20.508
3bhy7CPDeath-associated protein kinase 3/0.507
2eb3ANPEpidermal growth factor receptor2.7.10.10.505
3zewSTUEphrin type-B receptor 42.7.10.10.504
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.504
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.503
2j7t274Serine/threonine-protein kinase 102.7.11.10.503
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.503
4gmy0X5Tyrosine-protein kinase JAK2/0.503
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.502
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.500
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.500
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.500
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.498
4jq8KJ8Epidermal growth factor receptor2.7.10.10.496
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.494
2hog710Serine/threonine-protein kinase Chk12.7.11.10.493
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.493
2qo9ANPEphrin type-A receptor 32.7.10.10.492
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.492
4jrvKJVEpidermal growth factor receptor2.7.10.10.491
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.490
2pzrACPFibroblast growth factor receptor 2/0.489
2wouZZFTGF-beta receptor type-12.7.11.300.487
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.486
2py3ACPFibroblast growth factor receptor 2/0.486
2yn8STUEphrin type-B receptor 42.7.10.10.486
5eg3ACPFibroblast growth factor receptor 2/0.485
2vwu7X1Ephrin type-B receptor 42.7.10.10.484
1wvxBD4Death-associated protein kinase 12.7.11.10.483
2ittAEEEpidermal growth factor receptor2.7.10.10.483
4gk4L90Ephrin type-A receptor 32.7.10.10.483
5dr9SKEAurora kinase A2.7.11.10.483
2xp2VGHALK tyrosine kinase receptor2.7.10.10.482
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.482
4gk2L66Ephrin type-A receptor 32.7.10.10.482
2itzIREEpidermal growth factor receptor2.7.10.10.480
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.480
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.480
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.479
3w33W19Epidermal growth factor receptor2.7.10.10.479
4c62XWWTyrosine-protein kinase JAK2/0.479
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.478
2fgiPD1Fibroblast growth factor receptor 1/0.477
2x6dX6DAurora kinase A2.7.11.10.477
3ac1KZITyrosine-protein kinase Lck2.7.10.20.477
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.477
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.477
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.477
4gk3L87Ephrin type-A receptor 32.7.10.10.476
4j99ACPFibroblast growth factor receptor 2/0.476
4y95746Tyrosine-protein kinase/0.476
2vwx7X4Ephrin type-B receptor 42.7.10.10.475
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.475
3s4qNK0Mitogen-activated protein kinase 14/0.475
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.474
2c6eHPMAurora kinase A2.7.11.10.474
3vs1VSATyrosine-protein kinase HCK2.7.10.20.474
4i231C9Epidermal growth factor receptor2.7.10.10.474
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.474
4jr3KJREpidermal growth factor receptor2.7.10.10.473
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.471
5e8xSTUTGF-beta receptor type-12.7.11.300.471
1bygSTUTyrosine-protein kinase CSK/0.470
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.469
4hvh19RTyrosine-protein kinase JAK32.7.10.20.469
4y93746Tyrosine-protein kinase/0.469
1oecAA2Fibroblast growth factor receptor 2/0.468
4k33ACPFibroblast growth factor receptor 32.7.10.10.468
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
4nk92K5Fibroblast growth factor receptor 1/0.468
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.468
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.467
1finATPCyclin-dependent kinase 22.7.11.220.467
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2itqITQEpidermal growth factor receptor2.7.10.10.467
2pzpACPFibroblast growth factor receptor 2/0.467
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.467
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.467
1py5PY1TGF-beta receptor type-12.7.11.300.466
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.466
2qocANPEphrin type-A receptor 32.7.10.10.466
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4wkqIREEpidermal growth factor receptor2.7.10.10.466
2qoqANPEphrin type-A receptor 32.7.10.10.465
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.465
4jia1K3Tyrosine-protein kinase JAK2/0.465
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.465
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.464
2pvlP55Casein kinase II subunit alpha2.7.11.10.464
4bcmT7ZCyclin-dependent kinase 22.7.11.220.464
4btkDTQTau-tubulin kinase 12.7.11.10.464
4hni16WCasein kinase I isoform epsilon2.7.11.10.464
5aaaVGHALK tyrosine kinase receptor2.7.10.10.464
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.463
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.463
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.463
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.462
2pvyACPFibroblast growth factor receptor 2/0.462
4anqVGHALK tyrosine kinase receptor2.7.10.10.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
3tucFPWTyrosine-protein kinase SYK2.7.10.20.461
4cd0AWJALK tyrosine kinase receptor2.7.10.10.461
4riyADPEpidermal growth factor receptor2.7.10.10.461
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.459
1xkkFMMEpidermal growth factor receptor2.7.10.10.459
2itpAEEEpidermal growth factor receptor2.7.10.10.459
2y6o1N1Ephrin type-A receptor 42.7.10.10.459
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.459
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.459
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.459
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.458
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4g2fC07Ephrin type-A receptor 32.7.10.10.458
4ic7ANPMitogen-activated protein kinase 72.7.11.240.458
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.458
1xl2189Gag-Pol polyprotein3.4.23.160.457
2xa4AZ5Tyrosine-protein kinase JAK2/0.457
3emg685Tyrosine-protein kinase SYK2.7.10.20.457
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4aotGW8Serine/threonine-protein kinase 102.7.11.10.457
4id71G0Activated CDC42 kinase 1/0.457
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.457
5e8ySTUTGF-beta receptor type-22.7.11.300.457
1zyjBI5Mitogen-activated protein kinase 14/0.456
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.456
3oom507Activin receptor type-12.7.11.300.456
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.456
4f630S7Fibroblast growth factor receptor 1/0.456
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
2xngA0HAurora kinase A2.7.11.10.455
2z2w770Wee1-like protein kinase2.7.10.20.455
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.455
4hvg19QTyrosine-protein kinase JAK32.7.10.20.455
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.455
2pz5ACPFibroblast growth factor receptor 2/0.454
2xyuQ9GEphrin type-A receptor 42.7.10.10.454
3a7hATPSerine/threonine-protein kinase 242.7.11.10.454
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.454
3mtfA3FActivin receptor type-12.7.11.300.453
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.453
3uvp048Mitogen-activated protein kinase 14/0.453
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.452
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.452
3ac2KSETyrosine-protein kinase Lck2.7.10.20.452
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.452
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.452
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.452
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.451
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.451
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.451
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4jq7KJQEpidermal growth factor receptor2.7.10.10.451
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.450
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.450
1u54ACPActivated CDC42 kinase 1/0.450
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.450
3ezrEZRCyclin-dependent kinase 22.7.11.220.450
3igoANPCalmodulin-domain protein kinase 1, putative/0.450
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.450
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.449
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.449
2xvdAS6Ephrin type-B receptor 42.7.10.10.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.449
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4i22IREEpidermal growth factor receptor2.7.10.10.449
1k6tXN1Gag-Pol polyprotein3.4.23.160.448
1vjy460TGF-beta receptor type-12.7.11.300.448
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.448
3vryB43Tyrosine-protein kinase HCK2.7.10.20.448
4c57FEFCyclin-G-associated kinase2.7.11.10.448
4hvi19STyrosine-protein kinase JAK32.7.10.20.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1zrzBI1Protein kinase C iota type2.7.11.130.447
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.447
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.447
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
2ijmADPFocal adhesion kinase 12.7.10.20.446
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2vwy7X5Ephrin type-B receptor 42.7.10.10.446
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.446
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.446
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.446
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.446
3reyXACAdenosine receptor A2a/0.446
1rbyKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.445
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.445
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.445
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.445
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
1yvj4STTyrosine-protein kinase JAK32.7.10.20.444
2csnCKICasein kinase I homolog 12.7.11.10.444
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.444
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.444
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.444
4fyn0VETyrosine-protein kinase SYK2.7.10.20.444
5cnnANPEpidermal growth factor receptor2.7.10.10.444
1hncGDNGlutathione S-transferase Mu 22.5.1.180.443
2a0cCK9Cyclin-dependent kinase 22.7.11.220.443
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.443
2vd5BI8Myotonin-protein kinase2.7.11.10.443
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.443
3lpbNVBTyrosine-protein kinase JAK2/0.443
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.443
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.443
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4c02TAKActivin receptor type-12.7.11.300.443
4dce0JFALK tyrosine kinase receptor2.7.10.10.443
5dt0SKEAurora kinase A2.7.11.10.443
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
3gubGUBDeath-associated protein kinase 12.7.11.10.442
3w2rW2REpidermal growth factor receptor2.7.10.10.442
4fnzNZFALK tyrosine kinase receptor2.7.10.10.442
2vww7X2Ephrin type-B receptor 42.7.10.10.441
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
3eb0DRKUncharacterized protein/0.441
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.441
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fnyI3KALK tyrosine kinase receptor2.7.10.10.441
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.441
4o0sADNAurora kinase A2.7.11.10.441
1dkfBMSRetinoic acid receptor alpha/0.440
2bujSTUSerine/threonine-protein kinase 16/0.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440
4hyu1BKMitogen-activated protein kinase 82.7.11.240.440