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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qftFADNADPH--cytochrome P450 reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qftFADNADPH--cytochrome P450 reductase/1.000
3qfsFADNADPH--cytochrome P450 reductase/0.592
1amoFADNADPH--cytochrome P450 reductase/0.555
1ja1FADNADPH--cytochrome P450 reductase/0.538
1w35FADFerredoxin--NADP reductase1.18.1.20.538
4y9rFADNADPH--cytochrome P450 reductase/0.536
4yaoFADNADPH--cytochrome P450 reductase/0.535
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.525
3w5uFADFerredoxin/0.519
3zc3FADFerredoxin--NADP reductase1.18.1.20.515
1sm4FADFerredoxin--NADP reductase/0.509
1j9zFADNADPH--cytochrome P450 reductase/0.508
1gawFADFerredoxin/0.507
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.507
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.507
4c43FADFerredoxin--NADP reductase1.18.1.20.507
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.506
1w87FADFerredoxin--NADP reductase1.18.1.20.503
3vo2FADFerredoxin--NADP reductase/0.503
1gjrFADFerredoxin--NADP reductase1.18.1.20.497
1h85FADFerredoxin--NADP reductase1.18.1.20.494
1rkwPNTHTH-type transcriptional regulator QacR/0.494
1e63FADFerredoxin--NADP reductase1.18.1.20.493
1qh0FADFerredoxin--NADP reductase1.18.1.20.490
3ojxFADNADPH--cytochrome P450 reductase/0.490
1go2FADFerredoxin--NADP reductase1.18.1.20.487
3fpkFADFerredoxin-NADP reductase/0.487
1queFADFerredoxin--NADP reductase1.18.1.20.485
1bjkFADFerredoxin--NADP reductase1.18.1.20.482
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.482
1qgyFADFerredoxin--NADP reductase1.18.1.20.482
2b5oFADFerredoxin--NADP reductase1.18.1.20.482
1h42FADFerredoxin--NADP reductase1.18.1.20.481
2rc6FADFerredoxin--NADP reductase/0.481
2gevCOKPantothenate kinase2.7.1.330.480
1gaqFADFerredoxin/0.479
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.479
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.478
3h3r14HCollagen type IV alpha-3-binding protein/0.477
1po7TZDBenzoylformate decarboxylase4.1.1.70.476
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.471
3zbtFADFerredoxin--NADP reductase1.18.1.20.469
2ok8FADFerredoxin--NADP reductase, apicoplast/0.466
4bfvZVVPantothenate kinase2.7.1.330.465
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.464
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.464
4gm4TZDBenzoylformate decarboxylase4.1.1.70.463
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.459
1qgzFADFerredoxin--NADP reductase1.18.1.20.458
1x1cSAHC-20 methyltransferase/0.458
4bfxZVXPantothenate kinase2.7.1.330.458
1e64FADFerredoxin--NADP reductase1.18.1.20.457
2gbyBRNHTH-type transcriptional regulator QacR/0.455
3junAJDPhenazine biosynthesis protein A/B/0.455
2bgiFADNADPH:ferredoxin reductase/0.454
2geuCOKPantothenate kinase2.7.1.330.454
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.454
1gr1FADFerredoxin--NADP reductase1.18.1.20.453
1mczRMNBenzoylformate decarboxylase4.1.1.70.453
4jtqNAPAldo-keto reductase family 1 member C2/0.453
1fdrFADFerredoxin--NADP reductase1.18.1.20.452
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.452
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
1b2rFADFerredoxin--NADP reductase1.18.1.20.451
2rc5FADFerredoxin--NADP reductase/0.451
3fhxPLPPyridoxal kinase2.7.1.350.451
3h3sH15Collagen type IV alpha-3-binding protein/0.451
1qtiGNTAcetylcholinesterase3.1.1.70.450
3ivcFG4Pantothenate synthetase6.3.2.10.450
4j7gTRHPCZA361.3/0.449
1toiHCIAspartate aminotransferase2.6.1.10.448
3djjFADGlutathione reductase, mitochondrial1.8.1.70.448
3fazNOSPurine nucleoside phosphorylase/0.448
4bftZVTPantothenate kinase2.7.1.330.448
1a8pFADFerredoxin--NADP reductase/0.447
1f20FADNitric oxide synthase, brain1.14.13.390.447
1yw8A75Methionine aminopeptidase 2/0.447
3otwCOAPhosphopantetheine adenylyltransferase/0.446
1ogiFADFerredoxin--NADP reductase1.18.1.20.445
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
2j3qTFLAcetylcholinesterase3.1.1.70.444
4xo7NAPAldo-keto reductase family 1 member C2/0.444
2vnjFADNADPH:ferredoxin reductase/0.443
3tneRITCandidapepsin-13.4.23.240.443
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.443
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.443
4lu3AZMCarbonic anhydrase 144.2.1.10.443
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.443
1ogjFADFerredoxin--NADP reductase1.18.1.20.442
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
2a9y26AAdenosine kinase2.7.1.200.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3qgf46FGenome polyprotein2.7.7.480.442
4b7zQ4QAcetylcholinesterase3.1.1.70.442
3ny9JSZBeta-2 adrenergic receptor/0.442
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.441
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.441
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.441
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1o9bNAIQuinate/shikimate dehydrogenase/0.440
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.440
3e4vFMNUncharacterized protein/0.440
5hvnNAD3-dehydroquinate synthase/0.440