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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3q9zTXQCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3q9zTXQCasein kinase II subunit alpha2.7.11.11.000
3q9xEMOCasein kinase II subunit alpha2.7.11.10.606
5cvhADPCasein kinase II subunit alpha2.7.11.10.561
4dgnLU2Casein kinase II subunit alpha2.7.11.10.549
2pvlP55Casein kinase II subunit alpha2.7.11.10.541
2pvnP63Casein kinase II subunit alpha2.7.11.10.541
1m2pHNACasein kinase II subunit alpha2.7.11.10.536
4jr7GNPCasein kinase II subunit alpha2.7.11.10.536
1m2qMNXCasein kinase II subunit alpha2.7.11.10.535
4dgo0JWCasein kinase II subunit alpha2.7.11.10.535
1m2rMNYCasein kinase II subunit alpha2.7.11.10.529
3be9P04Casein kinase II subunit alpha2.7.11.10.529
4anmWULCasein kinase II subunit alpha2.7.11.10.528
3nga3NGCasein kinase II subunit alpha2.7.11.10.521
3at3ATKCasein kinase II subunit alpha2.7.11.10.520
3nszANPCasein kinase II subunit alpha2.7.11.10.520
1dawANPCasein kinase II subunit alpha2.7.11.10.519
1lp4ANPCasein kinase II subunit alpha2.7.11.10.519
5cshATPCasein kinase II subunit alpha2.7.11.10.518
4mwhATPCasein kinase II subunit alpha2.7.11.10.517
4fi1ATPCasein kinase II subunit alpha2.7.11.10.516
1om1IQACasein kinase II subunit alpha2.7.11.10.511
2pvhP19Casein kinase II subunit alpha2.7.11.10.509
1cqp803Integrin alpha-L/0.508
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.503
2wihP48Cyclin-dependent kinase 22.7.11.220.499
1dayGNPCasein kinase II subunit alpha2.7.11.10.496
4dgmAGICasein kinase II subunit alpha2.7.11.10.495
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.491
3at4CCKCasein kinase II subunit alpha2.7.11.10.491
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.491
4gub0Y4Casein kinase II subunit alpha2.7.11.10.491
4jqeANPCasein kinase II subunit alpha2.7.11.10.490
4grb0XGCasein kinase II subunit alpha2.7.11.10.488
2iw84SPCyclin-dependent kinase 22.7.11.220.483
3owk18ECasein kinase II subunit alpha2.7.11.10.483
3gwfFADCyclohexanone monooxygenase/0.482
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.482
3unj0BXCyclin-dependent kinase 22.7.11.220.482
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.481
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.480
3rk507ZCyclin-dependent kinase 22.7.11.220.480
4bgg844Activin receptor type-12.7.11.300.480
4qmpDKISerine/threonine-protein kinase 242.7.11.10.480
3owj1ELCasein kinase II subunit alpha2.7.11.10.479
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.478
2excJNKMitogen-activated protein kinase 102.7.11.240.477
3mb601ICasein kinase II subunit alpha2.7.11.10.477
3qu0X40Cyclin-dependent kinase 22.7.11.220.476
4k28NADShikimate dehydrogenase family protein/0.476
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
1pkdUCNCyclin-dependent kinase 22.7.11.220.474
1x2hLPALipoate-protein ligase A6.3.1.200.474
1xjdSTUProtein kinase C theta type2.7.11.130.474
1h1s4SPCyclin-dependent kinase 22.7.11.220.473
5dosATPAurora kinase A2.7.11.10.473
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.472
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.471
3uli1N3Cyclin-dependent kinase 22.7.11.220.470
4q73FADBifunctional protein PutA/0.470
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.469
2zaxCAMCamphor 5-monooxygenase1.14.15.10.469
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.469
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.469
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.469
1oi9N20Cyclin-dependent kinase 22.7.11.220.468
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.468
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.468
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.468
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
3wowANPCasein kinase II subunit alpha2.7.11.10.466
2c6tDT5Cyclin-dependent kinase 22.7.11.220.465
2cchATPCyclin-dependent kinase 22.7.11.220.465
3r7eX88Cyclin-dependent kinase 22.7.11.220.465
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.465
5dt4ATPAurora kinase A2.7.11.10.465
1di8DTQCyclin-dependent kinase 22.7.11.220.464
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.464
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.464
2uzlC94Cyclin-dependent kinase 22.7.11.220.464
2xa4AZ5Tyrosine-protein kinase JAK2/0.464
3ql8X01Cyclin-dependent kinase 22.7.11.220.464
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.463
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.463
3eljGS7Mitogen-activated protein kinase 82.7.11.240.463
3hllI45Mitogen-activated protein kinase 14/0.463
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.463
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.463
3r9oZ71Cyclin-dependent kinase 22.7.11.220.462
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
5e8wSTUTGF-beta receptor type-12.7.11.300.462
1ke9LS5Cyclin-dependent kinase 22.7.11.220.461
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.461
2vagV25Dual specificity protein kinase CLK12.7.12.10.461
3axwTIDCasein kinase II subunit alpha2.7.11.10.461
3pe6ZYHMonoglyceride lipase/0.461
3r9dX6BCyclin-dependent kinase 22.7.11.220.461
4l4cCAMCamphor 5-monooxygenase1.14.15.10.461
1e9hINRCyclin-dependent kinase 22.7.11.220.459
3imeBZ2Pantothenate synthetase6.3.2.10.459
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3owl19ECasein kinase II subunit alpha2.7.11.10.459
4eok4SPCyclin-dependent kinase 22.7.11.220.459
4g2fC07Ephrin type-A receptor 32.7.10.10.459
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.459
1likADNAdenosine kinase2.7.1.200.458
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.458
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.458
1jpaANPEphrin type-B receptor 22.7.10.10.457
1oiyN41Cyclin-dependent kinase 22.7.11.220.457
1rfvADPPyridoxal kinase2.7.1.350.457
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3mtfA3FActivin receptor type-12.7.11.300.457
3r9hZ67Cyclin-dependent kinase 22.7.11.220.457
4bcpT3CCyclin-dependent kinase 22.7.11.220.457
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.457
4lfiGNPCasein kinase II subunit alpha2.7.11.10.457
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
4g1wG1WMitogen-activated protein kinase 82.7.11.240.456
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.456
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.456
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.456
5auuLU2Death-associated protein kinase 12.7.11.10.456
1kkq471Peroxisome proliferator-activated receptor alpha/0.455
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.455
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
1eh4IC1Casein kinase I homolog 12.7.11.10.454
2c5nCK8Cyclin-dependent kinase 22.7.11.220.454
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2iw94SPCyclin-dependent kinase 22.7.11.220.454
3ibqATPPyridoxal kinase/0.454
3vt7VDXVitamin D3 receptor/0.454
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
3s1dZIRCytokinin dehydrogenase 11.5.99.120.453
3vryB43Tyrosine-protein kinase HCK2.7.10.20.453
3vt8YI3Vitamin D3 receptor/0.453
1u54ACPActivated CDC42 kinase 1/0.452
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.452
2np8CC3Aurora kinase A2.7.11.10.452
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.452
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.452
1ppjANYCytochrome b/0.451
3vt9YI4Vitamin D3 receptor/0.451
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.451
4c02TAKActivin receptor type-12.7.11.300.451
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.451
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.450
3qqkX02Cyclin-dependent kinase 22.7.11.220.450
3rni21ZCyclin-dependent kinase 22.7.11.220.450
4bcoT6QCyclin-dependent kinase 22.7.11.220.450
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.450
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.450
2qo9ANPEphrin type-A receptor 32.7.10.10.449
3d84NDPDihydrofolate reductase1.5.1.30.449
3pgqGY3Acetyl-CoA carboxylase/0.449
3ral04ZCyclin-dependent kinase 22.7.11.220.449
3rps4B0Casein kinase II subunit alpha2.7.11.10.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4eos1ROCyclin-dependent kinase 22.7.11.220.449
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.449
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4qmzB49Serine/threonine-protein kinase 242.7.11.10.449
3v2yML5Sphingosine 1-phosphate receptor 1/0.449
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1ol5ADPAurora kinase A2.7.11.10.448
1tj1FADBifunctional protein PutA1.5.5.20.448
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
4q72FADBifunctional protein PutA/0.448
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1pagFMPAntiviral protein I3.2.2.220.447
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.447
3r8pZ46Cyclin-dependent kinase 22.7.11.220.447
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.447
4a6cQG9Gag-Pol polyprotein3.4.23.160.447
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4dymIYZActivin receptor type-12.7.11.300.447
4fkw62KCyclin-dependent kinase 22.7.11.220.447
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.446
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1t86CAMCamphor 5-monooxygenase1.14.15.10.446
1v0oINRCell division control protein 2 homolog2.7.11.220.446
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3zxtACPDeath-associated protein kinase 12.7.11.10.446
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.446
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.446
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
5cvfATPCasein kinase II subunit alpha2.7.11.10.446
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.445
1ay0TPPTransketolase 12.2.1.10.445
1oiuN76Cyclin-dependent kinase 22.7.11.220.445
1vyw292Cyclin-dependent kinase 22.7.11.220.445
2acwUPGGlycosyltransferase/0.445
2izsBRQCasein kinase I isoform gamma-32.7.11.10.445
2vttLZDCyclin-dependent kinase 22.7.11.220.445
2xikJ60Serine/threonine-protein kinase 252.7.11.10.445
3a3bRBFLumazine protein/0.445
3l8p0CEAngiopoietin-1 receptor2.7.10.10.445
3r0tFU9Casein kinase II subunit alpha2.7.11.10.445
3u4uLNHCasein kinase II subunit alpha2.7.11.10.445
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.445
4l4bCAMCamphor 5-monooxygenase1.14.15.10.445
4riyADPEpidermal growth factor receptor2.7.10.10.445
4tuvCPZCytochrome P450 1191.140.445
5cp4CAMCamphor 5-monooxygenase1.14.15.10.445
1ke6LS2Cyclin-dependent kinase 22.7.11.220.444
1p9wANPType II secretion system protein E/0.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1udcUFMUDP-glucose 4-epimerase5.1.3.20.444
1wvxBD4Death-associated protein kinase 12.7.11.10.444
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.444
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.444
2j0k4STFocal adhesion kinase 12.7.10.20.444
2pv7NADT-protein1.3.1.120.444
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.444
2tscCB3Thymidylate synthase/0.444
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
2y6o1N1Ephrin type-A receptor 42.7.10.10.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3h86AP5Adenylate kinase/0.444
3r3f4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.444
4b4oNDPEpimerase family protein SDR39U1/0.444
4f7l0SOCyclin-dependent kinase 82.7.11.220.444
4gk3L87Ephrin type-A receptor 32.7.10.10.444
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.444
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.443
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.443
1rfuADPPyridoxal kinase2.7.1.350.443
1ungALHCyclin-dependent-like kinase 52.7.11.10.443
2fk8SAMHydroxymycolate synthase MmaA42.1.10.443
2pvmP29Casein kinase II subunit alpha2.7.11.10.443
2xlrFADPutative flavin-containing monooxygenase/0.443
3a9wNADNDP-sugar epimerase/0.443
3nr4PYVAbscisic acid receptor PYL2/0.443
3oom507Activin receptor type-12.7.11.300.443
3r6xX84Cyclin-dependent kinase 22.7.11.220.443
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1m78NDPDihydrofolate reductase1.5.1.30.442
1rx8FOLDihydrofolate reductase1.5.1.30.442
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.442
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.442
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.442
2gjlFMNNitronate monooxygenase1.13.12.160.442
2j09FMNDeoxyribodipyrimidine photo-lyase4.1.99.30.442
2p33J07Mitogen-activated protein kinase 102.7.11.240.442
2uzeC95Cyclin-dependent kinase 22.7.11.220.442
2zdt46CMitogen-activated protein kinase 102.7.11.240.442
3c13EMOCasein kinase II subunit alpha2.7.11.10.442
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.442
3rpv26ZCyclin-dependent kinase 22.7.11.220.442
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4fkv61KCyclin-dependent kinase 22.7.11.220.442
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
5auwQUEDeath-associated protein kinase 12.7.11.10.442
1dm2HMDCyclin-dependent kinase 22.7.11.220.441
1f4gTP4Thymidylate synthase/0.441
1ia3TQ5Dihydrofolate reductase1.5.1.30.441
1xddAAYIntegrin alpha-L/0.441
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.441
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.441
2dwbANPAurora kinase A2.7.11.10.441
2eufLQQCyclin-dependent kinase 62.7.11.220.441
2i40BLZCyclin-dependent kinase 22.7.11.220.441
2oapANPType II secretion system protein (GspE-2)/0.441
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3csdEMOPutative ketoacyl reductase1.3.10.441
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.441
3qtzX42Cyclin-dependent kinase 22.7.11.220.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4c57FEFCyclin-G-associated kinase2.7.11.10.441
4eoi1ROCyclin-dependent kinase 22.7.11.220.441
4gk2L66Ephrin type-A receptor 32.7.10.10.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4ii5ADPCyclin-dependent kinase 22.7.11.220.441
4l49CAMCamphor 5-monooxygenase1.14.15.10.441
4wboANWRhodopsin kinase/0.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
1nooCAHCamphor 5-monooxygenase1.14.15.10.440
2qboCAMCamphor 5-monooxygenase1.14.15.10.440
2w17I19Cyclin-dependent kinase 22.7.11.220.440
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.440
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440
3rmf20ZCyclin-dependent kinase 22.7.11.220.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
4btjADPTau-tubulin kinase 12.7.11.10.440
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.440