sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3q1f | YPP | Beta-lactamase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3q1f | YPP | Beta-lactamase | / | 1.000 | |
| 4de0 | 0JB | Beta-lactamase | / | 0.580 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.575 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.574 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.570 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.553 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.548 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.494 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.490 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.487 | |
| 2bxm | IMN | Serum albumin | / | 0.485 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.483 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.482 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.481 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.475 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.474 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.474 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.473 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.473 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.472 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.472 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.472 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2o12 | FMN | Chorismate synthase | / | 0.471 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.471 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.470 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.470 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.470 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.469 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.469 | |
| 1e2n | RCA | Thymidine kinase | / | 0.468 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.468 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.467 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.467 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.467 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.467 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.467 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.466 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.466 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.466 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.466 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.465 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.465 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.464 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.464 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.464 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.464 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.464 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.464 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.464 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.463 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.463 | |
| 4qec | NAP | ElxO | / | 0.463 | |
| 5dp2 | NAP | CurF | / | 0.463 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.462 | |
| 2egb | SAH | Diphthine synthase | / | 0.462 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.461 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.461 | |
| 3b9l | AZZ | Serum albumin | / | 0.461 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.461 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.461 | |
| 4f97 | VDO | Putative glycosyltransferase | / | 0.461 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.461 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.460 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.460 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.459 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.459 | |
| 4s1h | ADP | Pyridoxal kinase, putative | / | 0.459 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.459 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.458 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.458 | |
| 1jzq | ILA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.458 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.458 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.458 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.457 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.457 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.457 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.457 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.457 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.457 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.456 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 1wng | SAH | Diphthine synthase | / | 0.456 | |
| 2en5 | SAH | Diphthine synthase | / | 0.456 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.456 | |
| 2pci | SAH | Diphthine synthase | / | 0.456 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.456 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.456 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.456 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.456 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.456 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.456 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.456 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.455 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.455 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.455 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.455 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.455 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.455 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.455 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.455 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 2ejk | SAH | Diphthine synthase | / | 0.454 | |
| 2owk | SAH | Diphthine synthase | / | 0.454 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.454 | |
| 4eu4 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.454 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.454 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.453 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.453 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.453 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.453 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.453 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 1csc | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.452 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.452 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.452 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.452 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.452 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.452 | |
| 2el0 | SAH | Diphthine synthase | / | 0.452 | |
| 2eni | SAH | Diphthine synthase | / | 0.452 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.452 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.451 | |
| 2e16 | SAH | Diphthine synthase | / | 0.451 | |
| 2owu | SAH | Diphthine synthase | / | 0.451 | |
| 2p5f | SAH | Diphthine synthase | / | 0.451 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.451 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.451 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.451 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4f6r | GDP | Tubulin beta chain | / | 0.451 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.451 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.451 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 2eka | SAH | Diphthine synthase | / | 0.450 | |
| 2emr | SAH | Diphthine synthase | / | 0.450 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.450 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2p5c | SAH | Diphthine synthase | / | 0.450 | |
| 2p6i | SAH | Diphthine synthase | / | 0.450 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.450 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.449 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.449 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.449 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.449 | |
| 2e17 | SAH | Diphthine synthase | / | 0.449 | |
| 2egs | SAH | Diphthine synthase | / | 0.449 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.449 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.449 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.449 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.449 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.449 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.448 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.448 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.448 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.448 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.448 | |
| 2pcm | SAH | Diphthine synthase | / | 0.448 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.448 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.448 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 2dxx | SAH | Diphthine synthase | / | 0.447 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.447 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.447 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.447 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.447 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.446 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.446 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.446 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.446 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2dsh | SAH | Diphthine synthase | / | 0.446 | |
| 2e8q | SAH | Diphthine synthase | / | 0.446 | |
| 2egl | SAH | Diphthine synthase | / | 0.446 | |
| 2emu | SAH | Diphthine synthase | / | 0.446 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.446 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.446 | |
| 3qvi | K95 | HAP protein | / | 0.446 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.446 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.446 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.446 | |
| 4e2d | FMN | Dehydrogenase | / | 0.446 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.446 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.445 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.445 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.445 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 2e07 | SAH | Diphthine synthase | / | 0.445 | |
| 2e7r | SAH | Diphthine synthase | / | 0.445 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.445 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.445 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.445 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3upf | 0BU | Polyprotein | / | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.445 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.444 | |
| 1i5z | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.444 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.444 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 2e8h | SAH | Diphthine synthase | / | 0.444 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.444 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.444 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.444 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 5fkm | TDC | Tetracycline repressor protein class D | / | 0.444 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.443 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 1nqm | BTN | Streptavidin | / | 0.443 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.443 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.443 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.443 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.443 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3e39 | FMN | Nitroreductase | / | 0.443 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.443 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.443 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4jic | FMN | GTN Reductase | / | 0.443 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.443 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.442 | |
| 1eq2 | ADQ | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.442 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.442 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.442 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.442 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2dsi | SAH | Diphthine synthase | / | 0.442 | |
| 2dxv | SAH | Diphthine synthase | / | 0.442 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.442 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.442 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.442 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.441 | |
| 2e15 | SAH | Diphthine synthase | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.441 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.441 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.441 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.441 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.441 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.441 | |
| 4ozn | ATP | Ammonium transporter | / | 0.441 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.441 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 5fko | TDC | Tetracycline repressor protein class D | / | 0.441 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.440 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1vpm | COA | Acyl-CoA hydrolase | / | 0.440 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.440 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2eld | SAH | Diphthine synthase | / | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2npf | MOU | Elongation factor 2 | / | 0.440 | |
| 2owv | SAH | Diphthine synthase | / | 0.440 | |
| 2p6l | SAH | Diphthine synthase | / | 0.440 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.440 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.440 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.440 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.440 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.440 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.440 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.440 |