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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.60

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.601.000
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.719
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.714
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.677
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.616
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.613
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.589
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.584
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.557
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.484
3q7fED2Uncharacterized protein/0.476
3sfy3FYUncharacterized protein/0.469
3sfxJANUncharacterized protein/0.464
1ry0PG2Aldo-keto reductase family 1 member C3/0.455
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.452
3n0hTOPDihydrofolate reductase1.5.1.30.444