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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pxkPXKFocal adhesion kinase 12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pxkPXKFocal adhesion kinase 12.7.10.21.000
2ijmATPFocal adhesion kinase 12.7.10.20.601
4k8aK8AFocal adhesion kinase 12.7.10.20.551
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.522
2ijmADPFocal adhesion kinase 12.7.10.20.515
2j0lANPFocal adhesion kinase 12.7.10.20.505
2j0m4STFocal adhesion kinase 12.7.10.20.492
3zewSTUEphrin type-B receptor 42.7.10.10.488
4y95746Tyrosine-protein kinase/0.480
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
1i44ACPInsulin receptor2.7.10.10.476
2jkoBIJFocal adhesion kinase 12.7.10.20.476
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.475
4y93746Tyrosine-protein kinase/0.475
2v7a627Tyrosine-protein kinase ABL12.7.10.20.474
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.474
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.474
4o0wADNAurora kinase A2.7.11.10.474
2x9fX9FEphrin type-B receptor 42.7.10.10.471
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.471
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.470
2zjwREFCasein kinase II subunit alpha2.7.11.10.469
4jajXU1Aurora kinase A2.7.11.10.469
4jia1K3Tyrosine-protein kinase JAK2/0.469
4fob0USALK tyrosine kinase receptor2.7.10.10.468
3i60E86Mitogen-activated protein kinase 12.7.11.240.467
3lpbNVBTyrosine-protein kinase JAK2/0.467
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.467
2btsU32Cyclin-dependent kinase 22.7.11.220.466
2w1fL0FAurora kinase A2.7.11.10.466
3iok1P6Tyrosine-protein kinase JAK2/0.466
3zmmF9JTyrosine-protein kinase JAK2/0.466
4b99R4LMitogen-activated protein kinase 72.7.11.240.466
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.466
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.465
2xvdAS6Ephrin type-B receptor 42.7.10.10.465
4bcmT7ZCyclin-dependent kinase 22.7.11.220.465
4l9i8PRRhodopsin kinase/0.465
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.465
4aqc88ATyrosine-protein kinase JAK2/0.464
4o0uADNAurora kinase A2.7.11.10.464
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.463
4fod0UVALK tyrosine kinase receptor2.7.10.10.463
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.462
2bfyH1NAurora kinase B-A2.7.11.10.461
5dr6SKEAurora kinase A2.7.11.10.461
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.460
5dt0SKEAurora kinase A2.7.11.10.460
4foc0UUALK tyrosine kinase receptor2.7.10.10.459
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.459
2pvnP63Casein kinase II subunit alpha2.7.11.10.458
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2xb7GUIALK tyrosine kinase receptor2.7.10.10.457
4jboWPHAurora kinase A2.7.11.10.457
2etm7PYFocal adhesion kinase 12.7.10.20.456
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.456
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.455
4dgnLU2Casein kinase II subunit alpha2.7.11.10.455
3c4xATPRhodopsin kinase/0.454
3lltANPProtein serine/threonine kinase-1/0.454
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.454
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.453
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.453
4btjADPTau-tubulin kinase 12.7.11.10.453
5dr9SKEAurora kinase A2.7.11.10.453
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.452
5dosATPAurora kinase A2.7.11.10.452
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.451
4h3qANPMitogen-activated protein kinase 12.7.11.240.451
4hvi19STyrosine-protein kinase JAK32.7.10.20.451
4jqeANPCasein kinase II subunit alpha2.7.11.10.451
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.450
2xa4AZ5Tyrosine-protein kinase JAK2/0.450
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3my5RFZCyclin-dependent kinase 22.7.11.220.449
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4g1wG1WMitogen-activated protein kinase 82.7.11.240.449
4grb0XGCasein kinase II subunit alpha2.7.11.10.449
4gu94GUFocal adhesion kinase 12.7.10.20.449
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
2pvmP29Casein kinase II subunit alpha2.7.11.10.448
2x1nX1NCyclin-dependent kinase 22.7.11.220.448
3c4wATPRhodopsin kinase/0.448
3rak03ZCyclin-dependent kinase 22.7.11.220.448
1m2rMNYCasein kinase II subunit alpha2.7.11.10.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
4hge15VTyrosine-protein kinase JAK2/0.447
1u54ACPActivated CDC42 kinase 1/0.446
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3be9P04Casein kinase II subunit alpha2.7.11.10.446
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.446
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.446
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4b8lA0PAurora kinase B-A2.7.11.10.446
4deeADPAurora kinase A2.7.11.10.446
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.445
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.445
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.445
1m2pHNACasein kinase II subunit alpha2.7.11.10.444
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.444
4ji91M3Tyrosine-protein kinase JAK2/0.444
5av2KMPDeath-associated protein kinase 12.7.11.10.444
4ewhT77Activated CDC42 kinase 1/0.443
4f650S9Fibroblast growth factor receptor 1/0.443
5dt3ATPAurora kinase A2.7.11.10.443
1om1IQACasein kinase II subunit alpha2.7.11.10.442
2pwlACPFibroblast growth factor receptor 2/0.442
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.442
4eooATPCyclin-dependent kinase 22.7.11.220.442
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
2yaaATPDeath-associated protein kinase 2/0.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
5dpvSKEAurora kinase A2.7.11.10.441
1oirHDYCyclin-dependent kinase 22.7.11.220.440
2hog710Serine/threonine-protein kinase Chk12.7.11.10.440
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.440
4j95ACPFibroblast growth factor receptor 2/0.440
4nifANPMitogen-activated protein kinase 12.7.11.240.440