sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3ppk	FNI	Serine/threonine-protein kinase B-raf	2.7.11.1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3ppk	FNI	Serine/threonine-protein kinase B-raf	2.7.11.1	1.000
3prf	FP3	Serine/threonine-protein kinase B-raf	2.7.11.1	0.628
4wo5	324	Serine/threonine-protein kinase B-raf	2.7.11.1	0.562
2fb8	215	Serine/threonine-protein kinase B-raf	2.7.11.1	0.544
4fk3	325	Serine/threonine-protein kinase B-raf	2.7.11.1	0.538
4g34	924	Eukaryotic translation initiation factor 2-alpha kinase 3	2.7.11.1	0.472
3bi6	396	Wee1-like protein kinase	2.7.10.2	0.461
4g31	0WH	Eukaryotic translation initiation factor 2-alpha kinase 3	2.7.11.1	0.452
3cqe	P91	Wee1-like protein kinase	2.7.10.2	0.451
3biz	61E	Wee1-like protein kinase	2.7.10.2	0.444
3cr0	809	Wee1-like protein kinase	2.7.10.2	0.440