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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pg3DG7Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pg3DG7Mitogen-activated protein kinase 14/1.000
1w7h3IPMitogen-activated protein kinase 14/0.522
3itzP66Mitogen-activated protein kinase 14/0.520
3hv3R49Mitogen-activated protein kinase 14/0.506
3gcq1BUMitogen-activated protein kinase 14/0.502
3lfcZ86Mitogen-activated protein kinase 14/0.502
2gfsPQBMitogen-activated protein kinase 14/0.491
3fl4FL4Mitogen-activated protein kinase 14/0.477
3hub469Mitogen-activated protein kinase 14/0.477
3l8sBFFMitogen-activated protein kinase 14/0.475
3zsh469Mitogen-activated protein kinase 14/0.471
3ds6A17Mitogen-activated protein kinase 14/0.464
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.459
3upyFOMOxidoreductase, putative/0.459
3bx5304Mitogen-activated protein kinase 14/0.458
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.455
3fknFKNMitogen-activated protein kinase 14/0.454
2ewaSB2Mitogen-activated protein kinase 14/0.452
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.447
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.446
3fkoFKOMitogen-activated protein kinase 14/0.445
2zb1GK4Mitogen-activated protein kinase 14/0.444
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.444
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.444
3lthUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
3l0lHC3Nuclear receptor ROR-gamma/0.442
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.442
3hucG97Mitogen-activated protein kinase 14/0.441
3vf60H6Glucokinase2.7.1.20.441
2c9ePIDPeridinin-chlorophyll a protein, high-salt form/0.440