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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p7cP7CMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3p7cP7CMitogen-activated protein kinase 14/1.000
3p7bP7BMitogen-activated protein kinase 14/0.723
2yisYISMitogen-activated protein kinase 14/0.666
3o8uBMUMitogen-activated protein kinase 14/0.625
3p7aP7AMitogen-activated protein kinase 14/0.621
1kv2B96Mitogen-activated protein kinase 14/0.605
3lfbZ87Mitogen-activated protein kinase 14/0.596
3hv6R39Mitogen-activated protein kinase 14/0.584
3uvr06FMitogen-activated protein kinase 14/0.538
1kv1BMUMitogen-activated protein kinase 14/0.528
3d83GK6Mitogen-activated protein kinase 14/0.522
3gcuR48Mitogen-activated protein kinase 14/0.510
3gcvSS6Mitogen-activated protein kinase 14/0.510
4eh90OQMitogen-activated protein kinase 14/0.510
3nnxEDDMitogen-activated protein kinase 14/0.509
1wbsLI2Mitogen-activated protein kinase 14/0.508
3p5kP5KMitogen-activated protein kinase 14/0.503
1wbvLI3Mitogen-activated protein kinase 14/0.501
3p79P79Mitogen-activated protein kinase 14/0.501
3nnwEDDMitogen-activated protein kinase 14/0.493
2e2b406Tyrosine-protein kinase ABL12.7.10.20.491
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.487
1w82L10Mitogen-activated protein kinase 14/0.483
3nnuEDBMitogen-activated protein kinase 14/0.482
1wbnL09Mitogen-activated protein kinase 14/0.477
3lffZ83Mitogen-activated protein kinase 14/0.475
1wbtWBTMitogen-activated protein kinase 14/0.474
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.471
3gcsBAXMitogen-activated protein kinase 14/0.467
2yiwYIWMitogen-activated protein kinase 14/0.465
3npcB96Mitogen-activated protein kinase 92.7.11.240.462
2hyySTITyrosine-protein kinase ABL12.7.10.20.457
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.456
3qw2NADMyo-inositol-1-phosphate synthase (Ino1)/0.454
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
1wbwLI4Mitogen-activated protein kinase 14/0.447
3e9319BMitogen-activated protein kinase 14/0.447
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.446
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.445
2v51LABActin, alpha skeletal muscle/0.444
4b1uLABActin, alpha skeletal muscle/0.444
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.444
3hv71AUMitogen-activated protein kinase 14/0.443
3ldgSAHUncharacterized protein/0.443
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.443
2hznKINTyrosine-protein kinase ABL12.7.10.20.441
3gi3B10Mitogen-activated protein kinase 14/0.440
4aqc88ATyrosine-protein kinase JAK2/0.440