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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p19NDPPutative blue fluorescent protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3p19NDPPutative blue fluorescent protein/1.000
4j7xNAPSepiapterin reductase1.1.1.1530.523
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.513
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.513
1ae1NAPTropinone reductase 1/0.511
4j7uNAPSepiapterin reductase1.1.1.1530.506
4hwkNAPSepiapterin reductase1.1.1.1530.504
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.496
3l77NJPShort-chain alcohol dehydrogenase/0.494
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.493
1w4zNAPPutative ketoacyl reductase1.3.10.492
1x7gNAPPutative ketoacyl reductase1.3.10.491
3sjuNDPKeto reductase/0.490
3tn7NJPShort-chain alcohol dehydrogenase/0.490
2bd0NAPSepiapterin reductase/0.489
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.489
1ipeNDPTropinone reductase 21.1.1.2360.484
1oaaNAPSepiapterin reductase1.1.1.1530.482
3qrwNDPPutative ketoacyl reductase1.3.10.482
3toxNAPPutative oxidoreductase/0.482
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
4dc1NDPPutative ketoacyl reductase1.3.10.480
2jahNDPClavaldehyde dehydrogenase/0.478
4qecNAPElxO/0.477
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.473
2dteNAIGlucose 1-dehydrogenase related protein/0.472
5idwNAPShort-chain dehydrogenase/reductase SDR/0.471
1xg5NAPDehydrogenase/reductase SDR family member 11/0.470
1gcoNADGlucose 1-dehydrogenase1.1.1.470.469
4qedNAPElxO/0.468
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.465
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.464
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.462
1xkqNDPUncharacterized protein/0.461
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.460
1n5dNDPCarbonyl reductase [NADPH] 1/0.460
2yutNAPPutative short-chain oxidoreductase/0.460
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.459
1snyNAPLD36273p/0.455
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.454
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.453
1g6kNADGlucose 1-dehydrogenase1.1.1.470.452
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.452
4gh5NADShort-chain dehydrogenase/reductase SDR/0.452
1geeNADGlucose 1-dehydrogenase1.1.1.470.451
1pr9NAPL-xylulose reductase1.1.1.100.451
4bmvNAPShort-chain dehydrogenase/0.450
5jlaNADPutative short-chain dehydrogenase/reductase/0.449
3d3wNAPL-xylulose reductase1.1.1.100.448
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.447
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.445
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.444
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3f1kNAPUncharacterized oxidoreductase YciK10.442
1wntNAPL-xylulose reductase1.1.1.100.441