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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.11.000
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.557
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.552
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.527
5av2KMPDeath-associated protein kinase 12.7.11.10.516
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.510
3bqr4RBDeath-associated protein kinase 3/0.507
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.504
4jia1K3Tyrosine-protein kinase JAK2/0.498
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.496
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.495
5av3KMPDeath-associated protein kinase 12.7.11.10.494
2yaaATPDeath-associated protein kinase 2/0.493
1jklANPDeath-associated protein kinase 12.7.11.10.492
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.489
3gu7ADPDeath-associated protein kinase 12.7.11.10.477
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.476
1jkkANPDeath-associated protein kinase 12.7.11.10.475
4ysjADPCalmodulin-like domain protein kinase/0.473
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.471
2ckeIQUDeath-associated protein kinase 2/0.470
3c4xATPRhodopsin kinase/0.470
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.467
4l9i8PRRhodopsin kinase/0.467
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.463
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.463
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.463
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.463
4bcmT7ZCyclin-dependent kinase 22.7.11.220.460
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
2vrx447Aurora kinase B-A2.7.11.10.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.455
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
1ig1ANPDeath-associated protein kinase 12.7.11.10.453
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.452
3w2sW2REpidermal growth factor receptor2.7.10.10.452
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.451
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.448
4j99ACPFibroblast growth factor receptor 2/0.448
2j0lANPFocal adhesion kinase 12.7.10.20.447
3qxpX64Cyclin-dependent kinase 22.7.11.220.446
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3js2VM1Fibroblast growth factor receptor 1/0.445
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.444
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.443
2uzbC75Cyclin-dependent kinase 22.7.11.220.443
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.443
3lpbNVBTyrosine-protein kinase JAK2/0.442
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4grb0XGCasein kinase II subunit alpha2.7.11.10.441
3ztxZTXAurora kinase B-A2.7.11.10.440