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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3onwGDPGuanine nucleotide-binding protein G(i) subunit alpha-1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3onwGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/1.000
4g5qGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.571
3qi2GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.560
1gp2GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.529
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.475
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.473
4dieC5PCytidylate kinase/0.466
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.456
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.455
3b6zCO7Enoyl reductase LovC10.455
3fhyATPPyridoxal kinase2.7.1.350.455
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
4e03ADPPlasmid partitioning protein ParF/0.452
3b70NAPEnoyl reductase LovC10.449
2y05NAPProstaglandin reductase 1/0.448
1me6IVSPlasmepsin-23.4.23.390.447
2ozuACOHistone acetyltransferase KAT6A/0.445
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.445
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.444
2givACOHistone acetyltransferase KAT8/0.443
4gh5NADShort-chain dehydrogenase/reductase SDR/0.443
3d91REMRenin3.4.23.150.442
4b722FBBeta-secretase 13.4.23.460.442
2zjmF1MBeta-secretase 13.4.23.460.441
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.441
3otwCOAPhosphopantetheine adenylyltransferase/0.441
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.440
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.440
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ylrNAPPhenylacetone monooxygenase1.14.13.920.440
3qdlFMNOxygen-insensitive NADPH nitroreductase/0.440
3vyeVYERenin3.4.23.150.440
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.440