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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3och2MXDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3och2MXDihydrofolate reductase1.5.1.31.000
1ddsMTXDihydrofolate reductase1.5.1.30.614
1dhjMTXDihydrofolate reductase1.5.1.30.611
1draMTXDihydrofolate reductase1.5.1.30.586
1jolFFODihydrofolate reductase1.5.1.30.586
1dyjDDFDihydrofolate reductase1.5.1.30.584
4dfrMTXDihydrofolate reductase1.5.1.30.581
3drcMTXDihydrofolate reductase1.5.1.30.576
1ddrMTXDihydrofolate reductase1.5.1.30.575
2drcMTXDihydrofolate reductase1.5.1.30.572
1tdrMTXDihydrofolate reductase1.5.1.30.557
1re7FOLDihydrofolate reductase1.5.1.30.540
1drbMTXDihydrofolate reductase1.5.1.30.531
1dyiFOLDihydrofolate reductase1.5.1.30.524
1rb3MTXDihydrofolate reductase1.5.1.30.514
1dhiMTXDihydrofolate reductase1.5.1.30.499
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.488
1dyhDZFDihydrofolate reductase1.5.1.30.482
1rf7DHFDihydrofolate reductase1.5.1.30.473
1rb2FOLDihydrofolate reductase1.5.1.30.466
4cd2FOLDihydrofolate reductase1.5.1.30.464
1rd7FOLDihydrofolate reductase1.5.1.30.451
2qk8MTXDihydrofolate reductase/0.445
4ele31IDihydrofolate reductase/0.444
1diuBDMDihydrofolate reductase1.5.1.30.441
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441