sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 1.000 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.499 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.498 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.494 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.490 | |
| 3bbh | SFG | Ribosomal RNA small subunit methyltransferase Nep1 | 2.1.1 | 0.487 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.486 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.484 | |
| 3bbd | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | 2.1.1 | 0.479 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.479 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.477 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.475 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.475 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.474 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.472 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.472 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.472 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.471 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.471 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.470 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.470 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.469 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.469 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.469 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.468 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.468 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.467 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.467 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.466 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.465 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.465 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.465 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.465 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.465 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.465 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.465 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.465 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.464 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.464 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.464 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.464 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.464 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.464 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.464 | |
| 3s2v | 3HU | Glutamate receptor ionotropic, kainate 1 | / | 0.464 | |
| 4jic | FMN | GTN Reductase | / | 0.464 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.463 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.463 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.463 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.463 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.462 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.462 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.461 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.461 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.461 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.461 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.460 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.460 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3n14 | FMN | Xenobiotic reductase | / | 0.459 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.459 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.458 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.458 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.458 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.457 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.457 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.457 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.457 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.456 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.456 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.456 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4kgn | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.456 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.456 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.455 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.455 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.455 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.455 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.455 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.455 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.454 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.454 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.454 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.454 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.454 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.454 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.454 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.454 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.453 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.453 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.453 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.453 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.453 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.453 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.453 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.453 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.452 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.452 | |
| 2p9d | SAH | Diphthine synthase | / | 0.452 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.452 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.452 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.452 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.452 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.452 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.452 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.451 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.451 | |
| 4e2x | TYD | Methyltransferase | / | 0.451 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.451 | |
| 4y0k | NAP | AntE | / | 0.451 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.451 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.450 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2dxw | SAH | Diphthine synthase | / | 0.450 | |
| 2e16 | SAH | Diphthine synthase | / | 0.450 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 3a3g | DLZ | Lumazine protein | / | 0.450 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.450 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.450 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.450 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.449 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.449 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.449 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.449 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.449 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.449 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.448 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.448 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.448 | |
| 2ejk | SAH | Diphthine synthase | / | 0.448 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.448 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.448 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.448 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.448 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.448 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.447 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.447 | |
| 2ewv | ADP | Twitching motility protein PilT | / | 0.447 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.447 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.447 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.446 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 2egs | SAH | Diphthine synthase | / | 0.446 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.446 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.446 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.446 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.446 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.446 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.446 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.445 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.444 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.444 | |
| 2dsg | SAH | Diphthine synthase | / | 0.444 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.444 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.444 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.444 | |
| 3w1q | YRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.444 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.443 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.443 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2el0 | SAH | Diphthine synthase | / | 0.443 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.443 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.443 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4nvk | 2NY | Peroxidase | / | 0.443 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.443 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.442 | |
| 2dxv | SAH | Diphthine synthase | / | 0.442 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.442 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.442 | |
| 2pca | SAH | Diphthine synthase | / | 0.442 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.442 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.442 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.442 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.442 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.441 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.441 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4jal | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.441 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.440 | |
| 2emr | SAH | Diphthine synthase | / | 0.440 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.440 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3w2j | QRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.440 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.440 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.440 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.440 | |
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.440 |