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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ncgBK1Calmodulin-domain protein kinase 1, putative

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ncgBK1Calmodulin-domain protein kinase 1, putative/1.000
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.545
3l8p0CEAngiopoietin-1 receptor2.7.10.10.529
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.529
3gubGUBDeath-associated protein kinase 12.7.11.10.525
3igoANPCalmodulin-domain protein kinase 1, putative/0.521
4yuqKS1Calmodulin-like domain protein kinase/0.518
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.517
3ormAGSSerine/threonine protein kinase/0.517
4ih8B43Calmodulin-domain protein kinase 1/0.515
3mvl38PMitogen-activated protein kinase 14/0.512
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.512
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.510
4kb81QNCasein kinase I isoform delta2.7.11.10.510
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.508
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.505
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.504
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.504
1bygSTUTyrosine-protein kinase CSK/0.503
4y93746Tyrosine-protein kinase/0.503
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.502
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.502
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.501
4nk92K5Fibroblast growth factor receptor 1/0.500
2b1pAIZMitogen-activated protein kinase 102.7.11.240.499
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.498
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.498
3poz03PEpidermal growth factor receptor2.7.10.10.497
4kba1QMCasein kinase I isoform delta2.7.11.10.497
5auwQUEDeath-associated protein kinase 12.7.11.10.497
2excJNKMitogen-activated protein kinase 102.7.11.240.496
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.496
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3ttjJBIMitogen-activated protein kinase 102.7.11.240.495
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.494
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.493
3w2sW2REpidermal growth factor receptor2.7.10.10.492
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.492
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
4hyu1BKMitogen-activated protein kinase 82.7.11.240.492
4iarERM5-hydroxytryptamine receptor 1B/0.492
4b99R4LMitogen-activated protein kinase 72.7.11.240.491
4i22IREEpidermal growth factor receptor2.7.10.10.491
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.491
1dkfBMSRetinoic acid receptor alpha/0.490
2balPQAMitogen-activated protein kinase 14/0.490
3kf7L9GMitogen-activated protein kinase 14/0.490
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.490
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.490
3hllI45Mitogen-activated protein kinase 14/0.489
4y95746Tyrosine-protein kinase/0.489
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.488
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.488
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.487
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.486
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.486
4fob0USALK tyrosine kinase receptor2.7.10.10.486
4hnf16WCasein kinase I isoform delta2.7.11.10.486
3oom507Activin receptor type-12.7.11.300.485
3oroAGSSerine/threonine protein kinase/0.485
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.485
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.485
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.484
4nka2K7Fibroblast growth factor receptor 1/0.484
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.484
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.483
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.483
3w33W19Epidermal growth factor receptor2.7.10.10.483
1xkkFMMEpidermal growth factor receptor2.7.10.10.482
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.482
3iw4LW4Protein kinase C alpha type2.7.11.130.482
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
5aaaVGHALK tyrosine kinase receptor2.7.10.10.482
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.481
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.481
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.481
2hog710Serine/threonine-protein kinase Chk12.7.11.10.480
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.480
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.479
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.478
3ogqAB1Pol polyprotein/0.478
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.478
4oavACP2-5A-dependent ribonuclease3.1.260.478
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.477
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.477
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.477
4e730NRMitogen-activated protein kinase 82.7.11.240.477
3pgqGY3Acetyl-CoA carboxylase/0.476
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.476
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.476
4oauADP2-5A-dependent ribonuclease3.1.260.476
2wotZZGTGF-beta receptor type-12.7.11.300.475
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.475
3wxyCOAUncharacterized protein/0.475
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.475
4f640S8Fibroblast growth factor receptor 1/0.475
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.475
4nks2M2Fibroblast growth factor receptor 1/0.475
4fuxE75Mitogen-activated protein kinase 12.7.11.240.474
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.474
1ywrLI9Mitogen-activated protein kinase 14/0.473
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.473
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.473
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.473
4iebANPCalmodulin-domain protein kinase 1/0.473
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.473
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.472
2vgoAD5Aurora kinase B-A2.7.11.10.472
2vx17X8Ephrin type-B receptor 42.7.10.10.472
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.472
3mpaSB2Mitogen-activated protein kinase 14/0.472
3s4qNK0Mitogen-activated protein kinase 14/0.472
4gmy0X5Tyrosine-protein kinase JAK2/0.472
4iaq2GM5-hydroxytryptamine receptor 1B/0.472
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.472
4zseANPEpidermal growth factor receptor2.7.10.10.472
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.472
2ittAEEEpidermal growth factor receptor2.7.10.10.471
2j0k4STFocal adhesion kinase 12.7.10.20.471
2jedLG8Protein kinase C theta type2.7.11.130.471
2pwlACPFibroblast growth factor receptor 2/0.471
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.471
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.471
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.471
4xiwAZMCarbonic anhydrase, alpha type/0.471
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.470
1ouk084Mitogen-activated protein kinase 14/0.470
1zyjBI5Mitogen-activated protein kinase 14/0.470
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.470
4kiq1RAMitogen-activated protein kinase 14/0.470
4lopSB4Mitogen-activated protein kinase 14/0.470
5e8xSTUTGF-beta receptor type-12.7.11.300.470
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.469
3fklFKLMitogen-activated protein kinase 14/0.469
3vryB43Tyrosine-protein kinase HCK2.7.10.20.469
4ez50RSCyclin-dependent kinase 62.7.11.220.469
4gk2L66Ephrin type-A receptor 32.7.10.10.469
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.469
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.469
4nj32KDCyclin-dependent kinase 22.7.11.220.469
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.468
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.468
2hk51BMTyrosine-protein kinase HCK2.7.10.20.468
2vwz7X6Ephrin type-B receptor 42.7.10.10.468
3vquO22Dual specificity protein kinase TTK2.7.12.10.468
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.468
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.468
4ez8DHFThymidylate synthase2.1.1.450.468
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.467
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.467
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.467
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.467
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.467
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.467
5e8wSTUTGF-beta receptor type-12.7.11.300.467
2om9AJAPeroxisome proliferator-activated receptor gamma/0.466
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.466
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.466
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.466
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.466
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.466
4fod0UVALK tyrosine kinase receptor2.7.10.10.466
1h1r6CPCyclin-dependent kinase 22.7.11.220.465
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.465
1u4dDBQActivated CDC42 kinase 1/0.465
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.465
3flsFLSMitogen-activated protein kinase 14/0.465
3roc29AMitogen-activated protein kinase 14/0.465
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.465
4id71G0Activated CDC42 kinase 1/0.465
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.465
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.464
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.464
2itnANPEpidermal growth factor receptor2.7.10.10.464
2itzIREEpidermal growth factor receptor2.7.10.10.464
2o0uC0MMitogen-activated protein kinase 102.7.11.240.464
2vx07X7Ephrin type-B receptor 42.7.10.10.464
3h0sB38Acetyl-CoA carboxylase/0.464
3icrCOACoenzyme A disulfide reductase/0.464
3oriAGSSerine/threonine protein kinase/0.464
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.464
4ewqMWLMitogen-activated protein kinase 14/0.464
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.464
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.464
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2h96893Mitogen-activated protein kinase 82.7.11.240.463
2vwx7X4Ephrin type-B receptor 42.7.10.10.463
3gc9B45Mitogen-activated protein kinase 112.7.11.240.463
3gwfFADCyclohexanone monooxygenase/0.463
3ictADPCoenzyme A disulfide reductase/0.463
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
3w32W32Epidermal growth factor receptor2.7.10.10.463
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.463
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.463
4ic7ANPMitogen-activated protein kinase 72.7.11.240.463
4j97ACPFibroblast growth factor receptor 2/0.463
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.462
2hcdBIVVitamin D3 receptor A/0.462
2i0ePDSProtein kinase C beta type2.7.11.130.462
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.462
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.462
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.462
3fln3FNMitogen-activated protein kinase 14/0.462
3hl7I47Mitogen-activated protein kinase 14/0.462
3w2rW2REpidermal growth factor receptor2.7.10.10.462
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.462
4klrCHDFerrochelatase, mitochondrial4.99.1.10.462
2eq9FADDihydrolipoyl dehydrogenase/0.461
2gs7ANPEpidermal growth factor receptor2.7.10.10.461
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.461
3bu5ATPInsulin receptor2.7.10.10.461
3gggNADPrephenate dehydrogenase/0.461
3nww3NWMitogen-activated protein kinase 14/0.461
4nfn2KCTau-tubulin kinase 12.7.11.10.461
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.461
5av4GENDeath-associated protein kinase 12.7.11.10.461
1jioDEB6-deoxyerythronolide B hydroxylase/0.460
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1w2xRCPAcetyl-CoA carboxylase/0.460
1zg32HIIsoflavone 4'-O-methyltransferase/0.460
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.460
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.460
2p4yC03Peroxisome proliferator-activated receptor gamma/0.460
2py3ACPFibroblast growth factor receptor 2/0.460
2vwy7X5Ephrin type-B receptor 42.7.10.10.460
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.460
3h18PMSEsterase/lipase/0.460
4f630S7Fibroblast growth factor receptor 1/0.460
4g170VNCasein kinase I isoform gamma-32.7.11.10.460
4hjoAQ4Epidermal growth factor receptor2.7.10.10.460
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.459
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.459
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
3pe6ZYHMonoglyceride lipase/0.459
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.459
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
4erwSTUCyclin-dependent kinase 22.7.11.220.459
4hys1BJMitogen-activated protein kinase 82.7.11.240.459
4loqSB4Mitogen-activated protein kinase 14/0.459
1rj6AZMCarbonic anhydrase 144.2.1.10.458
2bfyH1NAurora kinase B-A2.7.11.10.458
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.458
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.458
2wqeADPAurora kinase A2.7.11.10.458
2zmd537Dual specificity protein kinase TTK2.7.12.10.458
3ntgD72Prostaglandin G/H synthase 21.14.99.10.458
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.458
3wy0COAUncharacterized protein/0.458
3zuyTCHTransporter/0.458
4em9TCEPeroxisome proliferator-activated receptor gamma/0.458
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.458
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.458
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.458
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.458
4i3wNADAldehyde dehydrogenase (NAD+)/0.458
5auzGENDeath-associated protein kinase 12.7.11.10.458
5drdATPAurora kinase A2.7.11.10.458
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.457
2ghlLIBMitogen-activated protein kinase 14/0.457
2q61SF1Peroxisome proliferator-activated receptor gamma/0.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.457
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.457
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.457
4aa4QC0Mitogen-activated protein kinase 14/0.457
4g1wG1WMitogen-activated protein kinase 82.7.11.240.457
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.457
4wboANWRhodopsin kinase/0.457
4xwtU5PRibonuclease J/0.457
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1v0pPVBCell division control protein 2 homolog2.7.11.220.456
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.456
3mqe416Prostaglandin G/H synthase 21.14.99.10.456
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.456
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.456
3uvqFS8Mitogen-activated protein kinase 14/0.456
3zk5Z18Cytochrome P450 monooxygenase PikC/0.456
4ansVGHALK tyrosine kinase receptor2.7.10.10.456
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.456
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.456
4jrvKJVEpidermal growth factor receptor2.7.10.10.456
3a4pDFQHepatocyte growth factor receptor2.7.10.10.455
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.455
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.455
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.455
4b7dQLECytochrome P450 monooxygenase PikC/0.455
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.455
4gk3L87Ephrin type-A receptor 32.7.10.10.455
4gu94GUFocal adhesion kinase 12.7.10.20.455
4kaoKAOFocal adhesion kinase 12.7.10.20.455
4pl3ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.455
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.455
1m17AQ4Epidermal growth factor receptor2.7.10.10.454
1ppm0P1Penicillopepsin-13.4.23.200.454
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.454
2vn0TDZCytochrome P450 2C8/0.454
2wedPP6Penicillopepsin-13.4.23.200.454
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.454
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.454
3w0oADPHygromycin-B 4-O-kinase2.7.1.1630.454
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.454
4anqVGHALK tyrosine kinase receptor2.7.10.10.454
4c4g7RODual specificity protein kinase TTK2.7.12.10.454
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4hnc0UTMandelate racemase/0.454
4hvh19RTyrosine-protein kinase JAK32.7.10.20.454
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4xgxADPFAD:protein FMN transferase/0.454
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.454
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.454
1p4fDRGDeath-associated protein kinase 12.7.11.10.453
2bujSTUSerine/threonine-protein kinase 16/0.453
2c7xNRBCytochrome P450 monooxygenase PikC/0.453
2vzmNRBCytochrome P450 monooxygenase PikC/0.453
3cgcFADCoenzyme A disulfide reductase/0.453
3dxjNE6DNA-directed RNA polymerase subunit beta/0.453
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.453
3fmkFMKMitogen-activated protein kinase 14/0.453
3icsADPCoenzyme A disulfide reductase/0.453
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.453
4bgg844Activin receptor type-12.7.11.300.453
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.453
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1q4t4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.452
1xjdSTUProtein kinase C theta type2.7.11.130.452
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.452
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.452
2q59240Peroxisome proliferator-activated receptor gamma/0.452
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.452
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.452
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
3a60STURibosomal protein S6 kinase beta-12.7.11.10.452
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.452
3q5iANPProtein kinase, putative/0.452
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
3rkb12ZCyclin-dependent kinase 22.7.11.220.452
3vs1VSATyrosine-protein kinase HCK2.7.10.20.452
4c02TAKActivin receptor type-12.7.11.300.452
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.452
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
1chwHXCChalcone synthase 22.3.1.740.451
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1zrzBI1Protein kinase C iota type2.7.11.130.451
2aibERGBeta-elicitin cinnamomin/0.451
2j0lANPFocal adhesion kinase 12.7.10.20.451
2o2u738Mitogen-activated protein kinase 102.7.11.240.451
2ociTYCValacyclovir hydrolase3.10.451
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.451
3bfa9ODOdorant binding protein ASP1/0.451
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.451
3le62BZCyclin-dependent kinase 22.7.11.220.451
3r34COA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.451
3v9v21LPeroxisome proliferator-activated receptor gamma/0.451
3vt8YI3Vitamin D3 receptor/0.451
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.451
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.451
4g160VMCasein kinase I isoform gamma-32.7.11.10.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
4jqeANPCasein kinase II subunit alpha2.7.11.10.451
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.451
4qmzB49Serine/threonine-protein kinase 242.7.11.10.451
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.450
1v9aSAHUncharacterized protein/0.450
2q5g1FAPeroxisome proliferator-activated receptor delta/0.450
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.450
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.450
3tmz06XCytochrome P450 2B41.14.14.10.450
3vthAPCCarbamoyltransferase/0.450
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.450
4c4f7CEDual specificity protein kinase TTK2.7.12.10.450
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4ubsDIFPentalenic acid synthase1.14.15.110.450
1i44ACPInsulin receptor2.7.10.10.449
1jpaANPEphrin type-B receptor 22.7.10.10.449
2of2547Tyrosine-protein kinase Lck2.7.10.20.449
2qocANPEphrin type-A receptor 32.7.10.10.449
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.449
2vrx447Aurora kinase B-A2.7.11.10.449
2xp2VGHALK tyrosine kinase receptor2.7.10.10.449
3cv9VDXVitamin D3 dihydroxylase/0.449
3hub469Mitogen-activated protein kinase 14/0.449
3hv6R39Mitogen-activated protein kinase 14/0.449
3nwyGTPUridylate kinase/0.449
3vt7VDXVitamin D3 receptor/0.449
3zuxTCHTransporter/0.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4eevL1XHepatocyte growth factor receptor2.7.10.10.449
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.449
4looSB4Mitogen-activated protein kinase 14/0.449
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4zcaADPKinesin-like protein KIF11/0.449
5auuLU2Death-associated protein kinase 12.7.11.10.449
5auxKMPDeath-associated protein kinase 12.7.11.10.449
1diuBDMDihydrofolate reductase1.5.1.30.448
1ol6ATPAurora kinase A2.7.11.10.448
1pagFMPAntiviral protein I3.2.2.220.448
2izrBRKCasein kinase I isoform gamma-32.7.11.10.448
2vd5BI8Myotonin-protein kinase2.7.11.10.448
2xikJ60Serine/threonine-protein kinase 252.7.11.10.448
3ctj320Hepatocyte growth factor receptor2.7.10.10.448
3gxlQIGTGF-beta receptor type-12.7.11.300.448
3il1B5DGlutamate receptor 2/0.448
3tk3CPZCytochrome P450 2B41.14.14.10.448
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.448
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.448
4gstGTDGlutathione S-transferase Mu 12.5.1.180.448
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.448
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.448
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.447
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.447
1h1s4SPCyclin-dependent kinase 22.7.11.220.447
1ir3ANPInsulin receptor2.7.10.10.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
1pp9SMACytochrome b/0.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.447
3csdEMOPutative ketoacyl reductase1.3.10.447
3kpkFADSulfide-quinone reductase/0.447
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
4bcqTJFCyclin-dependent kinase 22.7.11.220.447
4c61LMMTyrosine-protein kinase JAK2/0.447
4dtaADNAPH(2'')-Id/0.447
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.447
4jbqVX6Aurora kinase A2.7.11.10.447
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.447
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
4wkqIREEpidermal growth factor receptor2.7.10.10.447
4xldBRLPeroxisome proliferator-activated receptor gamma/0.447
1dyjDDFDihydrofolate reductase1.5.1.30.446
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.446
1ie4T44Transthyretin/0.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.446
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.446
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.446
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.446
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.446
2znnS44Peroxisome proliferator-activated receptor alpha/0.446
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.446
3d7tSTUTyrosine-protein kinase CSK/0.446
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.446
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.446
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.446
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.446
4kl9NDPDihydrofolate reductase1.5.1.30.446
4lsmNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
4o0sADNAurora kinase A2.7.11.10.446
4riyADPEpidermal growth factor receptor2.7.10.10.446
4z9rNADOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.446
1iyzNDPProbable quinone oxidoreductase/0.445
1lriCLRBeta-elicitin cryptogein/0.445
1ojtFADDihydrolipoyl dehydrogenase/0.445
1phePIYCamphor 5-monooxygenase1.14.15.10.445
2acxANPG protein-coupled receptor kinase 62.7.11.160.445
2ftoCB3Thymidylate synthase/0.445
2w05FRTCyclin-dependent kinase 22.7.11.220.445
2ydoADNAdenosine receptor A2a/0.445
2zbzVDXVitamin D3 dihydroxylase/0.445
3qaiXNNKetohexokinase/0.445
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3sz0FADSulfide-quinone reductase/0.445
3t2zFADSulfide-quinone reductase/0.445
3uzp0CKCasein kinase I isoform delta2.7.11.10.445
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.445
4c4h7RODual specificity protein kinase TTK2.7.12.10.445
4c59FEFCyclin-G-associated kinase2.7.11.10.445
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4k2xFADPolyketide oxygenase/hydroxylase/0.445
4kb81QOCasein kinase I isoform delta2.7.11.10.445
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4nxwADPMitochondrial dynamics protein MID51/0.445
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
5br4NADLactaldehyde reductase1.1.1.770.445
5eowFAD6-hydroxynicotinate 3-monooxygenase1.14.13.1140.445
5ii2LU2Protein polybromo-1/0.445
4z34ON7Lysophosphatidic acid receptor 1/0.445
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.444
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.444
1og5SWFCytochrome P450 2C9/0.444
1ot7IU5Bile acid receptor/0.444
1q4u4CA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.444
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
1sn5T3Transthyretin/0.444
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.444
1uyrD1LAcetyl-CoA carboxylase/0.444
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.444
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2pmdGNPTranslation initiation factor 2 subunit gamma/0.444
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.444
3b7dCNIGlutamate receptor 2/0.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4kgmATPUncharacterized protein/0.444
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.444
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.444
4ryvZEAProtein LlR18A/0.444
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.444
5f0a1FBcGMP-dependent protein kinase, putative/0.444
5k2aZMAAdenosine receptor A2a/0.444
1gih1PUCyclin-dependent kinase 22.7.11.220.443
1ictT44Transthyretin/0.443
1k6pXN3Gag-Pol polyprotein3.4.23.160.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
1phgMYTCamphor 5-monooxygenase1.14.15.10.443
1zeoC01Peroxisome proliferator-activated receptor gamma/0.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
2izsBRQCasein kinase I isoform gamma-32.7.11.10.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.443
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.443
3iw6PP0Mitogen-activated protein kinase 14/0.443
3my5RFZCyclin-dependent kinase 22.7.11.220.443
3opdHIEHeat shock protein 83/0.443
3w0rANPHygromycin-B 4-O-kinase2.7.1.1630.443
4a28ADPKinesin-like protein KIF11/0.443
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.443
4aotGW8Serine/threonine-protein kinase 102.7.11.10.443
4fnyI3KALK tyrosine kinase receptor2.7.10.10.443
4g2fC07Ephrin type-A receptor 32.7.10.10.443
4gg70J8Hepatocyte growth factor receptor2.7.10.10.443
4kwi1TJReductase homolog/0.443
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.443
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.442
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.442
2yfxVGHALK tyrosine kinase receptor2.7.10.10.442
3axwTIDCasein kinase II subunit alpha2.7.11.10.442
3bhlTHGThymidylate synthase/0.442
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.442
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.442
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3icrFADCoenzyme A disulfide reductase/0.442
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3qly55VUncharacterized protein/0.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
3zpuM8BGag-Pol polyprotein3.4.23.160.442
4b4oNDPEpimerase family protein SDR39U1/0.442
4b7sQLECytochrome P450 monooxygenase PikC/0.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.442
4j6dTESCytochrome P450 monooxygenase/0.442
4jaqCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.442
4kbc1QJCasein kinase I isoform delta2.7.11.10.442
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.442
4rrxLURProstaglandin G/H synthase 21.14.99.10.442
5awmANPStress-activated protein kinase JNK2.7.11.240.442
5jtbZMAAdenosine receptor A2a/0.442
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1ckpPVBCyclin-dependent kinase 22.7.11.220.441
1g67TZPThiamine-phosphate synthase/0.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.441
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
1zgaHMKIsoflavone 4'-O-methyltransferase/0.441
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.441
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2xneASHAurora kinase A2.7.11.10.441
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.441
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
3tqhNDPQuinone oxidoreductase/0.441
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4ejh0QACytochrome P450 2A131.14.14.10.441
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4hvg19QTyrosine-protein kinase JAK32.7.10.20.441
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4nxuADPMitochondrial dynamics protein MID51/0.441
4o761M3Bromodomain-containing protein 4/0.441
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.441
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5cwa0GAAnthranilate synthase component 14.1.3.270.441
1oecAA2Fibroblast growth factor receptor 2/0.440
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
1ykdCMPAdenylate cyclase/0.440
2ay84TBAromatic-amino-acid aminotransferase2.6.1.570.440
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.440
2cciATPCyclin-dependent kinase 22.7.11.220.440
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.440
2rkfAB1Pol protein/0.440
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.440
3emg685Tyrosine-protein kinase SYK2.7.10.20.440
3ictFADCoenzyme A disulfide reductase/0.440
3ns2PYVAbscisic acid receptor PYL2/0.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3sruQ26Dihydrofolate reductase1.5.1.30.440
4brxKGWFocal adhesion kinase 12.7.10.20.440
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.440
4cd0AWJALK tyrosine kinase receptor2.7.10.10.440
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4e37NDPCatalase1.11.1.60.440
4f650S9Fibroblast growth factor receptor 1/0.440
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.440
4ia2BIVVitamin D3 receptor A/0.440
4ly91YYGlucokinase regulatory protein/0.440
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.440
5dt4ATPAurora kinase A2.7.11.10.440