sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3n6u | TSU | HTH-type transcriptional regulator TsaR |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3n6u | TSU | HTH-type transcriptional regulator TsaR | / | 1.000 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.511 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.499 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.495 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.494 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.491 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.490 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.490 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.489 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.489 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.489 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.487 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.487 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.487 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.486 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.485 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.485 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.483 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.482 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.482 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.480 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.480 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.479 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.479 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.478 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.478 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.478 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.478 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.477 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.477 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.477 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.477 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.477 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.476 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.476 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.475 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.475 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.475 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.475 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.475 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 1bwa | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.474 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.474 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.474 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.472 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.471 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.471 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.471 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3fpa | DTB | ATP-dependent dethiobiotin synthetase BioD | / | 0.471 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.471 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.470 | |
| 2cjm | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.470 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.470 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.470 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.470 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.470 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.470 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.469 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.469 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.469 | |
| 4g73 | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.469 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.469 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.468 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.468 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.468 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.468 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.468 | |
| 3iaf | TPP | Benzaldehyde lyase | / | 0.468 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.468 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.467 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.467 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.467 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.467 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.467 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.467 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.467 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.466 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.466 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.466 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.466 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.466 | |
| 4kwh | NAP | Reductase homolog | / | 0.466 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.465 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.465 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.465 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.465 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.465 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.465 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.465 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.465 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.465 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.465 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.464 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3dk1 | G05 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 3k3b | ADP | Kinesin-like protein KIF11 | / | 0.464 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.464 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 5c4f | UPG | Histo-blood group ABO system transferase | / | 0.464 | |
| 1aj8 | COA | Citrate synthase | / | 0.463 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.463 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.463 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.463 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.463 | |
| 3ieu | GDP | GTPase Era | / | 0.463 | |
| 3lm9 | ADP | Putative fructokinase | 2.7.1.4 | 0.463 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.463 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.463 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.462 | |
| 1sn5 | T3 | Transthyretin | / | 0.462 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.462 | |
| 1zdw | FLV | Prenyltransferase | / | 0.462 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.462 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.462 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.462 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.461 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.461 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.461 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.461 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.461 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.461 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3qs8 | 17D | Anthranilate phosphoribosyltransferase | / | 0.461 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.461 | |
| 4k42 | ADP | Actin, alpha skeletal muscle | / | 0.461 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.461 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.461 | |
| 1c6y | MK1 | Protease | / | 0.460 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.460 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 1ylu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.460 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.460 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.460 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.460 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.460 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.460 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.460 | |
| 4ysj | ADP | Calmodulin-like domain protein kinase | / | 0.460 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.460 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.459 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.459 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.459 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.459 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.459 | |
| 1gqt | ACP | Ribokinase | / | 0.458 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.458 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.458 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.458 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 2cdu | FAD | NADH oxidase | / | 0.458 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.458 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.458 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.458 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.458 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.458 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.458 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4eu6 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.458 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.457 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.457 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.457 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 4a28 | ADP | Kinesin-like protein KIF11 | / | 0.457 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4cfa | WOP | Integrase | / | 0.457 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.457 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.457 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.457 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.456 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.456 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.456 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3up0 | D7S | aceDAF-12 | / | 0.456 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.456 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.456 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.455 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.455 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.455 | |
| 1nmd | ATP | Major actin | / | 0.455 | |
| 1ozp | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.455 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.455 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.455 | |
| 2fb2 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.455 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.455 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.455 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.455 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.455 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.455 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.455 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.455 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.455 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.454 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.454 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.454 | |
| 1vdc | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.454 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.454 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.454 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.454 | |
| 2i4u | DJR | Protease | / | 0.454 | |
| 2ph8 | 35A | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2yim | MC4 | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.454 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.454 | |
| 3qft | NAP | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.454 | |
| 4k7y | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.454 | |
| 4s1h | ADP | Pyridoxal kinase, putative | / | 0.454 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.454 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.453 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.453 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.453 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.453 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.453 | |
| 2xy9 | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.453 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.453 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.453 | |
| 4hxy | NDP | Plm1 | / | 0.453 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.453 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.453 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.453 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.452 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.452 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.452 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.452 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.452 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.452 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.452 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4ke0 | 1R8 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4l4x | NDP | AmphI | / | 0.452 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.452 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.452 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.452 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.451 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.451 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.451 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.451 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.451 | |
| 3a3g | DLZ | Lumazine protein | / | 0.451 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3cyw | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3wag | TYD | Glycosyltransferase | / | 0.451 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.451 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.451 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 5a3b | APR | SIR2 family protein | / | 0.451 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.450 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.450 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.450 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.450 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.450 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.450 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.450 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.450 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.450 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.450 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.450 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.450 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.450 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.450 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.450 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.449 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.449 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.449 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.449 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3chw | ATP | Major actin | / | 0.449 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.449 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.449 | |
| 3t8w | DGZ | M17 leucyl aminopeptidase | / | 0.449 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.449 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.449 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.449 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.449 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.448 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.448 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 1ppj | ANY | Cytochrome b | / | 0.448 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.448 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.448 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.448 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.448 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4eke | D1I | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.448 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.448 | |
| 4h4y | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.448 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.448 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.448 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.448 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.448 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.447 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.447 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1ng4 | FAD | Glycine oxidase | 1.4.3.19 | 0.447 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.447 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.447 | |
| 1qmz | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.447 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.447 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.447 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.447 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.447 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.447 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3gob | HXX | DdmC | / | 0.447 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3pfh | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.447 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.447 | |
| 3qem | QEM | Glutamate receptor ionotropic, NMDA 2B | / | 0.447 | |
| 3qem | QEM | NMDA glutamate receptor subunit | / | 0.447 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.447 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.447 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.447 | |
| 3zuy | TCH | Transporter | / | 0.447 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4cpd | NAD | Alcohol dehydrogenase | / | 0.447 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.447 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.446 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.446 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.446 | |
| 1w49 | APC | NTPase P4 | / | 0.446 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2b8t | THM | Thymidine kinase | / | 0.446 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.446 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.446 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.446 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 3up3 | XCA | aceDAF-12 | / | 0.446 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.446 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.446 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.446 | |
| 5c41 | ACP | Ribokinase | / | 0.446 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.446 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.445 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.445 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.445 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.445 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3e8x | NAP | BH1520 protein | / | 0.445 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.445 | |
| 3nwz | COA | BH2602 protein | / | 0.445 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.445 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.445 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.445 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.445 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.444 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.444 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1n06 | ADP | Riboflavin kinase | 2.7.1.26 | 0.444 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.444 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.444 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.444 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.444 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.444 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.444 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.444 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.444 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.444 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.444 | |
| 2vnn | CM7 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2vzz | SCA | Putative succinyl-CoA transferase Rv0802c | 2.8.3 | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.444 | |
| 3fx5 | KNI | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.444 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.444 | |
| 3px3 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.444 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.444 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.444 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.444 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.444 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4wxx | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.444 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.443 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.443 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.443 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.443 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.443 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 2i0d | MUT | Protease | / | 0.443 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.443 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.443 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.443 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.443 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.443 | |
| 4ktc | 1X3 | Genome polyprotein | 3.4.21.98 | 0.443 | |
| 4lx9 | ACO | N-alpha-acetyltransferase | 2.3.1 | 0.443 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.443 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 5c4c | UPG | Histo-blood group ABO system transferase | / | 0.443 | |
| 5cvc | PLP | Serine racemase | / | 0.443 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1bwb | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1xh5 | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.442 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.442 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.442 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.442 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.442 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.442 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3qqs | 17C | Anthranilate phosphoribosyltransferase | / | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.442 | |
| 4a1z | ADP | Kinesin-like protein KIF11 | / | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4bqu | CLR | Japanin | / | 0.442 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.442 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4kbz | 1QA | Egl nine homolog 1 | / | 0.442 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.442 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.442 | |
| 5byl | GCP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.442 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.442 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.441 | |
| 1c70 | L75 | Protease | / | 0.441 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.441 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1sny | NAP | LD36273p | / | 0.441 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1vza | UMP | Thymidylate synthase | / | 0.441 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.441 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.441 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.441 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.441 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.441 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.441 | |
| 3fxu | TSU | HTH-type transcriptional regulator TsaR | / | 0.441 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.441 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.441 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.441 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.441 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3ule | ATP | Actin-related protein 2 | / | 0.441 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.441 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4dt9 | GMP | APH(2'')-Id | / | 0.441 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.441 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.441 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4oae | CLM | Uncharacterized protein | / | 0.441 | |
| 4pkh | ADP | Actin, alpha skeletal muscle | / | 0.441 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 4xwz | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.440 | |
| 1gad | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.440 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.440 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.440 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.440 | |
| 2p5n | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 2r8p | T6F | Transketolase 1 | / | 0.440 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.440 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3nzk | C90 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.440 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.440 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.440 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.440 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4e2d | FMN | Dehydrogenase | / | 0.440 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ks7 | X4Z | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.440 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.440 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.440 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |