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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mpt1GKMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3mpt1GKMitogen-activated protein kinase 14/1.000
3iphG11Mitogen-activated protein kinase 14/0.676
4kin1M8Mitogen-activated protein kinase 14/0.599
4aa5NQBMitogen-activated protein kinase 14/0.596
3fln3FNMitogen-activated protein kinase 14/0.594
3fklFKLMitogen-activated protein kinase 14/0.590
2balPQAMitogen-activated protein kinase 14/0.585
2rg6287Mitogen-activated protein kinase 14/0.583
3flyFLYMitogen-activated protein kinase 14/0.576
3fskRO6Mitogen-activated protein kinase 14/0.569
4aacAAVMitogen-activated protein kinase 14/0.566
4kiq1RAMitogen-activated protein kinase 14/0.566
2rg5279Mitogen-activated protein kinase 14/0.559
3flzFLZMitogen-activated protein kinase 14/0.557
3dt1P40Mitogen-activated protein kinase 14/0.556
3fmh533Mitogen-activated protein kinase 14/0.556
3s4qNK0Mitogen-activated protein kinase 14/0.556
4kip1R9Mitogen-activated protein kinase 14/0.556
4aa4QC0Mitogen-activated protein kinase 14/0.552
3nww3NWMitogen-activated protein kinase 14/0.546
3l8xN4DMitogen-activated protein kinase 14/0.544
3hl7I47Mitogen-activated protein kinase 14/0.543
3fi4FI4Mitogen-activated protein kinase 14/0.540
3ocgOCGMitogen-activated protein kinase 14/0.539
4lopSB4Mitogen-activated protein kinase 14/0.539
2ghlLIBMitogen-activated protein kinase 14/0.515
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.512
3flwFLWMitogen-activated protein kinase 14/0.511
3mvm39PMitogen-activated protein kinase 14/0.507
2qd9LGFMitogen-activated protein kinase 14/0.504
1zz2B11Mitogen-activated protein kinase 14/0.501
2zazGK1Mitogen-activated protein kinase 14/0.499
2zb1GK4Mitogen-activated protein kinase 14/0.499
3gfeP37Mitogen-activated protein kinase 14/0.499
2zb0GK3Mitogen-activated protein kinase 14/0.495
3d7zGK5Mitogen-activated protein kinase 14/0.494
3hvcGG5Mitogen-activated protein kinase 14/0.493
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3vjoANPEpidermal growth factor receptor2.7.10.10.488
4looSB4Mitogen-activated protein kinase 14/0.488
1a72PADAlcohol dehydrogenase E chain1.1.1.10.487
3bv2P38Mitogen-activated protein kinase 14/0.486
3fmkFMKMitogen-activated protein kinase 14/0.485
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.484
4a8v2ANMajor pollen allergen Bet v 1-J/0.483
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.476
3bv3P39Mitogen-activated protein kinase 14/0.476
3zh8C58Protein kinase C iota type2.7.11.130.476
1ouk084Mitogen-activated protein kinase 14/0.473
2w3bNDPDihydrofolate reductase1.5.1.30.473
3gbuATPUncharacterized sugar kinase PH14592.7.10.472
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1zyjBI5Mitogen-activated protein kinase 14/0.470
4eh60ONMitogen-activated protein kinase 14/0.469
1agwSU2Fibroblast growth factor receptor 1/0.468
2nniMTKCytochrome P450 2C8/0.468
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.467
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.467
3gc9B45Mitogen-activated protein kinase 112.7.11.240.467
3t2vKKJPeptidoglycan recognition protein 1/0.467
2y6o1N1Ephrin type-A receptor 42.7.10.10.465
1xddAAYIntegrin alpha-L/0.464
3itzP66Mitogen-activated protein kinase 14/0.464
2qboCAMCamphor 5-monooxygenase1.14.15.10.463
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.463
3uvqFS8Mitogen-activated protein kinase 14/0.463
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.463
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.462
4i231C9Epidermal growth factor receptor2.7.10.10.462
3uyt0CKCasein kinase I isoform delta2.7.11.10.461
3ac2KSETyrosine-protein kinase Lck2.7.10.20.460
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.459
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.459
3e92G6AMitogen-activated protein kinase 14/0.459
3hllI45Mitogen-activated protein kinase 14/0.459
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.458
1h73ANPHomoserine kinase2.7.1.390.457
2briANPUridylate kinase2.7.4.220.457
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
4loqSB4Mitogen-activated protein kinase 14/0.457
2qo9ANPEphrin type-A receptor 32.7.10.10.456
1zrzBI1Protein kinase C iota type2.7.11.130.455
2a7r5GPGMP reductase 2/0.455
2itwITQEpidermal growth factor receptor2.7.10.10.455
2itxANPEpidermal growth factor receptor2.7.10.10.455
1dz6CAMCamphor 5-monooxygenase1.14.15.10.454
4l4fCAMCamphor 5-monooxygenase1.14.15.10.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
2aa3AP0L-lactate dehydrogenase/0.453
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.453
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.452
2ab8MTPAdenosine kinase2.7.1.200.452
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.452
2a1nCAMCamphor 5-monooxygenase1.14.15.10.451
2rlcCHDCholoylglycine hydrolase3.5.1.240.451
3nxxNDPDihydrofolate reductase1.5.1.30.451
3qlsNDPDihydrofolate reductase1.5.1.30.451
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.450
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.450
3d84NDPDihydrofolate reductase1.5.1.30.450
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.450
4c6uTLG3-oxoacyl-ACP synthase/0.450
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.450
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1fm4DXCMajor pollen allergen Bet v 1-L/0.449
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.449
1phePIYCamphor 5-monooxygenase1.14.15.10.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.449
3tjzGNPADP-ribosylation factor 1/0.449
1ezvUQ6Cytochrome b/0.448
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.448
2eb3ANPEpidermal growth factor receptor2.7.10.10.448
3fp0FP015-O-acetyltransferase/0.448
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.448
1rw8580TGF-beta receptor type-12.7.11.300.447
2gjlFMNNitronate monooxygenase1.13.12.160.447
2x8hFADThioredoxin glutathione reductase/0.447
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.447
4a802ANMajor pollen allergen Bet v 1-A/0.447
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.447
4g7gVFVLanosterol 14-alpha-demethylase/0.447
4jq7KJQEpidermal growth factor receptor2.7.10.10.447
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.447
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.447
1o76CAMCamphor 5-monooxygenase1.14.15.10.446
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.446
2of2547Tyrosine-protein kinase Lck2.7.10.20.446
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.446
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.446
4tuvCPZCytochrome P450 1191.140.446
4xr9NADCalS8/0.446
2bxoOPBSerum albumin/0.445
2ozuACOHistone acetyltransferase KAT6A/0.445
2z97CAMCamphor 5-monooxygenase1.14.15.10.445
3b6zCO7Enoyl reductase LovC10.445
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4fv7E94Mitogen-activated protein kinase 12.7.11.240.445
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.445
4l4cCAMCamphor 5-monooxygenase1.14.15.10.445
1dr3HBIDihydrofolate reductase1.5.1.30.444
1osvCHCBile acid receptor/0.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2qbmCAMCamphor 5-monooxygenase1.14.15.10.444
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3ac1KZITyrosine-protein kinase Lck2.7.10.20.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
4a86H35Major pollen allergen Bet v 1-A/0.444
4du82P0Mevalonate diphosphate decarboxylase/0.444
4jr3KJREpidermal growth factor receptor2.7.10.10.444
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.443
1tqf32PBeta-secretase 13.4.23.460.443
1trgCB3Thymidylate synthase/0.443
1ywrLI9Mitogen-activated protein kinase 14/0.443
2ien017Gag-Pol polyprotein3.4.23.160.443
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.443
2yyuC5POrotidine 5'-phosphate decarboxylase/0.443
3tucFPWTyrosine-protein kinase SYK2.7.10.20.443
4a99FADTetX family tetracycline inactivation enzyme/0.443
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.443
4dbzNDPPutative ketoacyl reductase1.3.10.443
4k28NADShikimate dehydrogenase family protein/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4rww2BALmo2692 protein/0.443
1adfTADAlcohol dehydrogenase E chain1.1.1.10.442
1rrmAPRLactaldehyde reductase1.1.1.770.442
3gobHXXDdmC/0.442
3nr4PYVAbscisic acid receptor PYL2/0.442
4a862ANMajor pollen allergen Bet v 1-A/0.442
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.442
4prvADPDNA gyrase subunit B/0.442
1di9MSQMitogen-activated protein kinase 14/0.441
2cig1DGDihydrofolate reductase1.5.1.30.441
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.441
2gfsPQBMitogen-activated protein kinase 14/0.441
2oegUPGUDP-glucose pyrophosphorylase/0.441
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.441
4bfzZVZPantothenate kinase2.7.1.330.441
4e5pNADPhosphonate dehydrogenase1.20.1.10.441
4g2fC07Ephrin type-A receptor 32.7.10.10.441
4jq8KJ8Epidermal growth factor receptor2.7.10.10.441
5dhhDGWNociceptin receptor/0.441
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.440
1me8RVPInosine-5'-monophosphate dehydrogenase/0.440
2itvANPEpidermal growth factor receptor2.7.10.10.440
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.440
2y3sTIRTamL/0.440
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.440
3lzs017Gag-Pol polyprotein3.4.23.160.440
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.440
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.440
4q73FADBifunctional protein PutA/0.440
4y93746Tyrosine-protein kinase/0.440