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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mpaSB2Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3mpaSB2Mitogen-activated protein kinase 14/1.000
3hp552PMitogen-activated protein kinase 14/0.562
3ha85JZMitogen-activated protein kinase 14/0.532
3fknFKNMitogen-activated protein kinase 14/0.518
3fskRO6Mitogen-activated protein kinase 14/0.512
3zsh469Mitogen-activated protein kinase 14/0.510
4g1wG1WMitogen-activated protein kinase 82.7.11.240.501
2ghmLICMitogen-activated protein kinase 14/0.500
3uvqFS8Mitogen-activated protein kinase 14/0.497
3fl4FL4Mitogen-activated protein kinase 14/0.496
4eym0RXMitogen-activated protein kinase 132.7.11.240.495
2gfsPQBMitogen-activated protein kinase 14/0.493
3ds6A17Mitogen-activated protein kinase 14/0.493
3hub469Mitogen-activated protein kinase 14/0.477
3flwFLWMitogen-activated protein kinase 14/0.469
3c5uP41Mitogen-activated protein kinase 14/0.468
4nka2K7Fibroblast growth factor receptor 1/0.466
3hl7I47Mitogen-activated protein kinase 14/0.464
3hllI45Mitogen-activated protein kinase 14/0.462
1ywrLI9Mitogen-activated protein kinase 14/0.460
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.459
3roc29AMitogen-activated protein kinase 14/0.459
2hw1ANPKetohexokinase/0.458
3s4qNK0Mitogen-activated protein kinase 14/0.458
3nww3NWMitogen-activated protein kinase 14/0.457
4e730NRMitogen-activated protein kinase 82.7.11.240.456
3flsFLSMitogen-activated protein kinase 14/0.452
3ttiKBIMitogen-activated protein kinase 102.7.11.240.452
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.452
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.450
3icsCOACoenzyme A disulfide reductase/0.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.449
2xrwANPMitogen-activated protein kinase 82.7.11.240.448
2xvdAS6Ephrin type-B receptor 42.7.10.10.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
2zb0GK3Mitogen-activated protein kinase 14/0.448
1pmn984Mitogen-activated protein kinase 102.7.11.240.446
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.446
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
4aacAAVMitogen-activated protein kinase 14/0.442
3nc9TR3Ketohexokinase/0.441
1zyjBI5Mitogen-activated protein kinase 14/0.440
3icrCOACoenzyme A disulfide reductase/0.440