sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 1.000 | |
| 3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.637 | |
| 4e9a | QAP | Peptide deformylase | / | 0.622 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.595 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.593 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.591 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.581 | |
| 1ws1 | BB2 | Peptide deformylase 1 | / | 0.568 | |
| 2ew6 | Y13 | Peptide deformylase | / | 0.568 | |
| 4e9b | BB2 | Peptide deformylase | / | 0.540 | |
| 1g2a | BB2 | Peptide deformylase | 3.5.1.88 | 0.525 | |
| 3uwb | BB2 | RIIA-RIIB membrane-associated protein | / | 0.519 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.515 | |
| 1s17 | GNR | Peptide deformylase | / | 0.515 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1g27 | BB1 | Peptide deformylase | 3.5.1.88 | 0.501 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.499 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.498 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.497 | |
| 3k6l | 2BB | Peptide deformylase | 3.5.1.88 | 0.497 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.492 | |
| 3e3u | NVC | Peptide deformylase | 3.5.1.88 | 0.491 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.491 | |
| 1lry | BB2 | Peptide deformylase | / | 0.490 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.488 | |
| 3m6r | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.487 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.482 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.482 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 4l4x | NDP | AmphI | / | 0.478 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.473 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.473 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.472 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.471 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.469 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.468 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.467 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.466 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.465 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.464 | |
| 1l4m | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.464 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.463 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4ple | CPS | Nuclear receptor subfamily 5 group A member 2 | / | 0.463 | |
| 5djt | FMN | NPH1-2 | / | 0.463 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.462 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.462 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.462 | |
| 4qec | NAP | ElxO | / | 0.462 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.461 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.461 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.461 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3g5k | BB2 | Peptide deformylase, mitochondrial | 3.5.1.88 | 0.461 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.461 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.460 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.460 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.458 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.458 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.458 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.458 | |
| 1jha | AAM | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.457 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.457 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.457 | |
| 4eox | 0S5 | Peptide deformylase | / | 0.457 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.456 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.456 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 4cje | Q31 | Integrase | / | 0.456 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.455 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.455 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.455 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1lqy | BB2 | Peptide deformylase 2 | 3.5.1.88 | 0.454 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.454 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.453 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 4yfy | 1YJ | VioF | / | 0.453 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
| 1l4k | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.452 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.452 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 3zv6 | 4HB | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.452 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.452 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1aj8 | COA | Citrate synthase | / | 0.451 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2jfz | 003 | Glutamate racemase | / | 0.451 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.451 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.450 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.450 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.450 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 4cfa | WOP | Integrase | / | 0.450 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.449 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.449 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.449 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.449 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.449 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.449 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.449 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.448 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.448 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.448 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.448 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.447 | |
| 1ci0 | FMN | Pyridoxamine 5'-phosphate oxidase | 1.4.3.5 | 0.447 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
| 1l4f | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.447 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.447 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.447 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.447 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.447 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.447 | |
| 4cj3 | E4F | Integrase | / | 0.447 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.447 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.446 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.446 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.446 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.446 | |
| 3zsr | O3N | Integrase | / | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4cez | O3N | Integrase | / | 0.446 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.445 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.445 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.445 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.445 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.444 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.444 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.444 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.444 | |
| 3vaq | ADN | Putative adenosine kinase | / | 0.444 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.444 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.444 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1l4l | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.443 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.443 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.443 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.443 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.443 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.443 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4asj | N6A | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.443 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1e80 | 0GQ | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.442 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 3rdo | BTN | Streptavidin | / | 0.442 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.442 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.442 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.442 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 1d0v | RBZ | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.441 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.441 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.441 | |
| 2ele | SAH | Diphthine synthase | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.441 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.441 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.441 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.441 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.441 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.441 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.441 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.441 | |
| 5bpf | ADP | D-alanine--D-alanine ligase | / | 0.441 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.440 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.440 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.440 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.440 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.440 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 4cgj | NZL | Integrase | / | 0.440 | |
| 4ck2 | NVU | Integrase | / | 0.440 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4mcc | 21X | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 |