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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m4h388Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3m4h388Aldose reductase1.1.1.211.000
3lboLDTAldose reductase1.1.1.210.872
3lqlLDTAldose reductase1.1.1.210.849
2fz9ZSTAldose reductase1.1.1.210.768
2pdxZSTAldose reductase1.1.1.210.750
4yu153NAldose reductase1.1.1.210.716
3m64393Aldose reductase1.1.1.210.711
2dv0ZSTAldose reductase1.1.1.210.710
1z8962PAldose reductase1.1.1.210.706
2hv5ZSTAldose reductase1.1.1.210.706
2ikj393Aldose reductase1.1.1.210.703
2duxZSTAldose reductase1.1.1.210.701
3lz5LDTAldose reductase1.1.1.210.695
1t40ID5Aldose reductase1.1.1.210.678
2hvnZSTAldose reductase1.1.1.210.673
4gca2X9Aldose reductase1.1.1.210.671
3mb9ZSTAldose reductase1.1.1.210.669
1t41ID5Aldose reductase1.1.1.210.668
1z3n3NAAldose reductase1.1.1.210.665
2iki388Aldose reductase1.1.1.210.643
2pdg47DAldose reductase1.1.1.210.640
3mc5393Aldose reductase1.1.1.210.640
1pwlBFIAldose reductase1.1.1.210.633
1us0LDTAldose reductase1.1.1.210.626
3m0iZSTAldose reductase1.1.1.210.616
2i16LDTAldose reductase1.1.1.210.613
2pdu393Aldose reductase1.1.1.210.612
2pdbZSTAldose reductase1.1.1.210.609
2pd5ZSTAldose reductase1.1.1.210.608
3lenZSTAldose reductase1.1.1.210.608
2fz8ZSTAldose reductase1.1.1.210.606
2hvoZSTAldose reductase1.1.1.210.606
2fzdTOLAldose reductase1.1.1.210.605
2ikhLITAldose reductase1.1.1.210.605
2qxwLDTAldose reductase1.1.1.210.604
2pdfZSTAldose reductase1.1.1.210.603
3ghrLDTAldose reductase1.1.1.210.602
2pdc393Aldose reductase1.1.1.210.601
3ghuLDTAldose reductase1.1.1.210.601
2pdn47DAldose reductase1.1.1.210.600
2pdh47DAldose reductase1.1.1.210.597
3t423T4Aldose reductase1.1.1.210.594
2pdp393Aldose reductase1.1.1.210.591
3ld5LDTAldose reductase1.1.1.210.588
2i17LDTAldose reductase1.1.1.210.585
2pzn393Aldose reductase1.1.1.210.585
1frbZSTAldose reductase-related protein 2/0.569
2pdj393Aldose reductase1.1.1.210.567
3ghsLDTAldose reductase1.1.1.210.567
2pfhNDPAldose reductase1.1.1.210.564
3g5eQ74Aldose reductase1.1.1.210.561
1ieiZESAldose reductase1.1.1.210.559
2pdq47DAldose reductase1.1.1.210.558
2pdiZSTAldose reductase1.1.1.210.552
2duzZSTAldose reductase1.1.1.210.546
1el3I84Aldose reductase1.1.1.210.543
2agtFIDAldose reductase1.1.1.210.534
3ghtLDTAldose reductase1.1.1.210.532
2pd9FIDAldose reductase1.1.1.210.513
5liu388Aldo-keto reductase family 1 member B101.1.10.511
1ah3TOLAldose reductase1.1.1.210.507
2f2kTGGAldose reductase1.1.1.210.498
1ekoI84Aldose reductase1.1.1.210.492
2pdlTOLAldose reductase1.1.1.210.482
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.481
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
3mjrAC2Deoxycytidine kinase2.7.1.740.480
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
4hmn16JAldo-keto reductase family 1 member C3/0.477
2inzOHPAldose reductase1.1.1.210.476
4wevSUZAldo-keto reductase family 1 member B101.1.10.476
4li61XOTankyrase-12.4.2.300.475
1ry8RUTAldo-keto reductase family 1 member C3/0.471
4fam0SZAldo-keto reductase family 1 member C3/0.471
2nvcITAAldose reductase1.1.1.210.470
2f3815MAldo-keto reductase family 1 member C3/0.468
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.468
4k4eK4ETankyrase-12.4.2.300.468
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.467
4kmzFOLFolate receptor beta/0.465
1dgbNDPCatalase1.11.1.60.463
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.463
2fzbTOLAldose reductase1.1.1.210.463
3b82NADExotoxin A2.4.2.360.462
3f3y4OABile salt sulfotransferase2.8.2.140.462
2bjsACVIsopenicillin N synthase1.21.3.10.461
3zkuHCVIsopenicillin N synthase1.21.3.10.461
4dbw511Aldo-keto reductase family 1 member C3/0.461
1obnASVIsopenicillin N synthase1.21.3.10.460
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.460
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.460
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.460
1yw9A84Methionine aminopeptidase 2/0.459
2iqdLPAAldose reductase1.1.1.210.459
3u2cSUZAldose reductase1.1.1.210.459
3v35NTIAldose reductase1.1.1.210.459
2pdwFIDAldose reductase1.1.1.210.458
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
2pdyFIDAldose reductase1.1.1.210.457
4bjbP34Tankyrase-22.4.2.300.457
1ah0SBIAldose reductase1.1.1.210.456
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1zuaTOLAldo-keto reductase family 1 member B101.1.10.456
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.456
1ef3FIDAldose reductase1.1.1.210.455
1yw7A41Methionine aminopeptidase 2/0.455
2aovC2MHistamine N-methyltransferase2.1.1.80.455
4ga8SBIAldo-keto reductase family 1 member B101.1.10.455
4kn2LYAFolate receptor beta/0.455
4phlPILPhosphodiesterase/0.455
4pnmNU1Tankyrase-22.4.2.300.455
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.454
2ga2A19Methionine aminopeptidase 2/0.453
4dz5NAPAldo-keto reductase family 1 member C3/0.453
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
1s2cFLFAldo-keto reductase family 1 member C3/0.452
2aotSAHHistamine N-methyltransferase2.1.1.80.452
2aouCQAHistamine N-methyltransferase2.1.1.80.452
2is72CLAldose reductase1.1.1.210.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.452
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.452
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.452
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.451
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.451
4u95MIYMultidrug efflux pump subunit AcrB/0.451
1e66HUXAcetylcholinesterase3.1.1.70.450
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.450
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.450
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.450
4kn0MTXFolate receptor beta/0.450
4psbGA3Cytokinin-specific binding protein/0.450
1bk0ACVIsopenicillin N synthase1.21.3.10.449
1ry0PG2Aldo-keto reductase family 1 member C3/0.449
4jtrIZPAldo-keto reductase family 1 member C2/0.449
1w6jR71Lanosterol synthase5.4.99.70.448
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.448
2oazI96Methionine aminopeptidase 2/0.448
3r43ID8Aldo-keto reductase family 1 member C3/0.448
4ey6GNTAcetylcholinesterase3.1.1.70.448
1esmCOAPantothenate kinase2.7.1.330.447
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.447
1s36CEIObelin/0.446
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3h7rNAPAldo-keto reductase family 4 member C8/0.446
3pn1IVHDNA ligase/0.446
3zkyWT4Isopenicillin N synthase1.21.3.10.446
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.445
2bfmTOPPteridine reductase 11.5.1.330.445
2gywOBIAcetylcholinesterase3.1.1.70.445
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
1gt5BZQOdorant-binding protein/0.444
2aot2PMHistamine N-methyltransferase2.1.1.80.444
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.444
2xupTZ5Acetylcholinesterase3.1.1.70.444
3ntqNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.444
3p2vDOYAldose reductase1.1.1.210.444
3r58NPSAldo-keto reductase family 1 member C3/0.444
3r8hZOMAldo-keto reductase family 1 member C3/0.444
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.444
3uweVJJAldo-keto reductase family 1 member C3/0.444
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.444
4mt92D6Tankyrase-12.4.2.300.444
1jf2CZHObelin/0.443
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1u08PLPMethionine aminotransferase/0.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2vt4P32Beta-1 adrenergic receptor/0.443
4jq2SUZAldo-keto reductase family 1 member C2/0.443
1adsNAPAldose reductase1.1.1.210.442
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3ugrIMNAldo-keto reductase family 1 member C3/0.442
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.442
1gm8SOXPenicillin G acylase3.5.1.110.441
1hb1OCVIsopenicillin N synthase1.21.3.10.441
1s1rNAPAldo-keto reductase family 1 member C3/0.441
1t7o152Carnitine O-acetyltransferase2.3.1.70.441
2ckmAA7Acetylcholinesterase3.1.1.70.441
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.441
3zc3FADFerredoxin--NADP reductase1.18.1.20.441
4b65NDPL-ornithine N(5)-monooxygenase/0.441
4j7gTRHPCZA361.3/0.441
4jqaID8Aldo-keto reductase family 1 member C2/0.441
4x9dU5PUncharacterized protein MJ1435/0.441
1vkgCRIHistone deacetylase 83.5.1.980.440
2xufTZ4Acetylcholinesterase3.1.1.70.440
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.440
3hl0NADMaleylacetate reductase/0.440
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/0.440