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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m42HGFMAP kinase-activated protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3m42HGFMAP kinase-activated protein kinase 22.7.11.11.000
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.625
3sheI85MAP kinase-activated protein kinase 32.7.11.10.555
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.525
1aq1STUCyclin-dependent kinase 22.7.11.220.520
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.504
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.501
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.500
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.496
2xikJ60Serine/threonine-protein kinase 252.7.11.10.493
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.492
2c6tDT5Cyclin-dependent kinase 22.7.11.220.481
3q43D66M1 family aminopeptidase3.4.110.479
3lfnA27Cyclin-dependent kinase 22.7.11.220.476
3rk708ZCyclin-dependent kinase 22.7.11.220.474
2xmyCDKCyclin-dependent kinase 22.7.11.220.473
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.472
1oirHDYCyclin-dependent kinase 22.7.11.220.472
1y91CT9Cyclin-dependent kinase 22.7.11.220.472
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.472
4qmzB49Serine/threonine-protein kinase 242.7.11.10.472
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.471
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.471
4ek610KCyclin-dependent kinase 22.7.11.220.471
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.469
1eh4IC1Casein kinase I homolog 12.7.11.10.468
1vikBAYGag-Pol polyprotein/0.468
3lfqA28Cyclin-dependent kinase 22.7.11.220.468
4fkg4CKCyclin-dependent kinase 22.7.11.220.468
4e4m0NHTyrosine-protein kinase JAK2/0.466
4fkt48KCyclin-dependent kinase 22.7.11.220.466
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.466
2hog710Serine/threonine-protein kinase Chk12.7.11.10.463
1vjy460TGF-beta receptor type-12.7.11.300.462
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.462
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.462
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.461
3i60E86Mitogen-activated protein kinase 12.7.11.240.461
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.461
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.459
3gubGUBDeath-associated protein kinase 12.7.11.10.459
4ek816KCyclin-dependent kinase 22.7.11.220.459
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.459
2b7aIZATyrosine-protein kinase JAK2/0.457
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.457
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.457
3qu0X40Cyclin-dependent kinase 22.7.11.220.456
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.456
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.456
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.455
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.455
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.455
3orkAGSSerine/threonine protein kinase/0.455
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.455
4fkv61KCyclin-dependent kinase 22.7.11.220.455
4kbk1QGCasein kinase I isoform delta2.7.11.10.455
1g5sI17Cyclin-dependent kinase 22.7.11.220.454
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.454
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.454
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.453
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.453
3kfs3TLGag-Pol polyprotein/0.453
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.453
1u4dDBQActivated CDC42 kinase 1/0.452
2fxdDR7Pol polyprotein/0.452
2p3b3TLV-1 PROTEASE protein/0.452
2p3b3TLV-1 protease/0.452
2qbuSAHPrecorrin-2 methyltransferase/0.452
3rk507ZCyclin-dependent kinase 22.7.11.220.452
3so9017Pol protein/0.452
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.452
1bygSTUTyrosine-protein kinase CSK/0.451
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.451
3qn8NI7Gag-Pol polyprotein3.4.23.160.451
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.450
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.450
1xddAAYIntegrin alpha-L/0.449
2b52D42Cyclin-dependent kinase 22.7.11.220.449
2b53D23Cyclin-dependent kinase 22.7.11.220.449
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.449
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.449
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
4c02TAKActivin receptor type-12.7.11.300.448
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.448
1p4fDRGDeath-associated protein kinase 12.7.11.10.447
1zys199Serine/threonine-protein kinase Chk12.7.11.10.447
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
2uznC96Cyclin-dependent kinase 22.7.11.220.447
3r83Z14Cyclin-dependent kinase 22.7.11.220.447
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.447
1xjdSTUProtein kinase C theta type2.7.11.130.446
2dwbANPAurora kinase A2.7.11.10.446
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
4lopSB4Mitogen-activated protein kinase 14/0.446
1om1IQACasein kinase II subunit alpha2.7.11.10.445
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.445
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.445
2iw94SPCyclin-dependent kinase 22.7.11.220.445
3qp0NI8Gag-Pol polyprotein3.4.23.160.445
3uli1N3Cyclin-dependent kinase 22.7.11.220.445
4a1zADPKinesin-like protein KIF11/0.445
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
5drdATPAurora kinase A2.7.11.10.445
1h1r6CPCyclin-dependent kinase 22.7.11.220.444
2btrU73Cyclin-dependent kinase 22.7.11.220.444
2iw84SPCyclin-dependent kinase 22.7.11.220.444
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.444
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.443
3rni21ZCyclin-dependent kinase 22.7.11.220.443
4iwd1JCHepatocyte growth factor receptor2.7.10.10.443
4kb81QNCasein kinase I isoform delta2.7.11.10.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
2uzeC95Cyclin-dependent kinase 22.7.11.220.442
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.442
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.442
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
2bhhRYUCyclin-dependent kinase 22.7.11.220.441
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.441
2btsU32Cyclin-dependent kinase 22.7.11.220.441
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1pxlCK4Cyclin-dependent kinase 22.7.11.220.440
2xnbY8LCyclin-dependent kinase 22.7.11.220.440
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3kfr3TLGag-Pol polyprotein/0.440
3zh8C58Protein kinase C iota type2.7.11.130.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.440