sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.704 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.695 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.678 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.670 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.572 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.558 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.557 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.556 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.556 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.554 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.554 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.553 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.548 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.548 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.547 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.543 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.541 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.539 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.537 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.536 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.532 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.528 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.521 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.521 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.521 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.519 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.514 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.512 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.511 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.507 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.505 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.500 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.499 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.498 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.496 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.495 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.492 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.492 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.490 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.484 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.484 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.482 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.482 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.480 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.477 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.477 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.477 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.475 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.475 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.474 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.473 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.473 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.472 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.472 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.472 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.471 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 4iae | 1DX | Alr2278 protein | / | 0.470 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.469 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.468 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.467 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.467 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.465 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.464 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.464 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.463 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 1c7o | PPG | Hemolysin | / | 0.462 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.460 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.460 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.459 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.459 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.458 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.457 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.457 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.457 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.455 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.455 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4iah | 1DX | Alr2278 protein | / | 0.455 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.454 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.454 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.454 | |
| 3wag | TYD | Glycosyltransferase | / | 0.454 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.454 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.454 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.453 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2wvl | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.453 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.452 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.452 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.452 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.452 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.450 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.450 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.450 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.450 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.450 | |
| 4rel | KMP | Glycosyltransferase | / | 0.450 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.449 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.449 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.448 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.448 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.448 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.448 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.448 | |
| 4y1b | NAP | AntE | / | 0.448 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 3ckq | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.447 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.447 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.447 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.447 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.447 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.446 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.446 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.446 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.446 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.446 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.445 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.445 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.445 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.445 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.444 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.444 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.444 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.443 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.443 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.443 | |
| 4nvk | 2NY | Peroxidase | / | 0.443 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.442 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.442 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.442 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 4c1e | MCO | Beta-lactamase class B VIM-2 | / | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.442 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.442 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.442 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 6gsu | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.442 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.442 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.441 | |
| 1phq | FPE | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.441 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.441 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.441 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.440 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.440 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.440 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.440 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 |