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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.11.000
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.623
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.528
3w32W32Epidermal growth factor receptor2.7.10.10.526
3w33W19Epidermal growth factor receptor2.7.10.10.523
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.506
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.496
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.483
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.483
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.476
3vs3VSETyrosine-protein kinase HCK2.7.10.20.476
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.472
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.464
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.463
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.456
4y93746Tyrosine-protein kinase/0.456
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.452
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.451
3w2sW2REpidermal growth factor receptor2.7.10.10.450
1xkkFMMEpidermal growth factor receptor2.7.10.10.448
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.446
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.442
4y95746Tyrosine-protein kinase/0.442
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.441