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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lltANPProtein serine/threonine kinase-1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lltANPProtein serine/threonine kinase-1/1.000
2yaaATPDeath-associated protein kinase 2/0.511
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.506
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.485
5av2KMPDeath-associated protein kinase 12.7.11.10.483
4anmWULCasein kinase II subunit alpha2.7.11.10.480
4grb0XGCasein kinase II subunit alpha2.7.11.10.479
4l9i8PRRhodopsin kinase/0.477
4bcmT7ZCyclin-dependent kinase 22.7.11.220.474
5av3KMPDeath-associated protein kinase 12.7.11.10.474
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3gu7ADPDeath-associated protein kinase 12.7.11.10.468
5cvfATPCasein kinase II subunit alpha2.7.11.10.468
1jklANPDeath-associated protein kinase 12.7.11.10.466
1om1IQACasein kinase II subunit alpha2.7.11.10.463
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.460
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.460
3c4xATPRhodopsin kinase/0.459
4dgmAGICasein kinase II subunit alpha2.7.11.10.459
4qnyANPMitogen activated protein kinase, putative/0.459
3my5RFZCyclin-dependent kinase 22.7.11.220.458
3bqr4RBDeath-associated protein kinase 3/0.457
3be9P04Casein kinase II subunit alpha2.7.11.10.456
2pvlP55Casein kinase II subunit alpha2.7.11.10.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3q9xEMOCasein kinase II subunit alpha2.7.11.10.453
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4ysjADPCalmodulin-like domain protein kinase/0.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
4dgnLU2Casein kinase II subunit alpha2.7.11.10.448
3axwTIDCasein kinase II subunit alpha2.7.11.10.445
1ig1ANPDeath-associated protein kinase 12.7.11.10.443
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.442
3u4uLNHCasein kinase II subunit alpha2.7.11.10.442
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.442
1jkkANPDeath-associated protein kinase 12.7.11.10.441
2ckeIQUDeath-associated protein kinase 2/0.441