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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3llaACPMyosin heavy chain kinase A2.7.11.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3llaACPMyosin heavy chain kinase A2.7.11.71.000
4zs4ATPMyosin heavy chain kinase A2.7.11.70.625
3pdtADPMyosin heavy chain kinase A2.7.11.70.613
5e9eANPMyosin heavy chain kinase A2.7.11.70.561
4zmeADNMyosin heavy chain kinase A2.7.11.70.559
1ia9ANPTransient receptor potential cation channel subfamily M member 72.7.11.10.550
3lmhADPMyosin heavy chain kinase A2.7.11.70.544
3lmiATPMyosin heavy chain kinase A2.7.11.70.540
1iahADPTransient receptor potential cation channel subfamily M member 72.7.11.10.525
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.476
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.465
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.453
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.443
3tubFPUTyrosine-protein kinase SYK2.7.10.20.442
3hziATPSerine/threonine-protein kinase toxin HipA/0.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3d5wADPSerine/threonine-protein kinase PLK/0.440