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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/1.000
3bqr4RBDeath-associated protein kinase 3/0.493
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.486
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.484
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.477
4ysjADPCalmodulin-like domain protein kinase/0.477
3zxtACPDeath-associated protein kinase 12.7.11.10.475
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.474
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.470
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.469
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.465
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.465
3ztxZTXAurora kinase B-A2.7.11.10.465
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.464
2vgpAD6Aurora kinase B-A2.7.11.10.461
3bu5ATPInsulin receptor2.7.10.10.461
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.461
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.459
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.457
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.457
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.456
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.455
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.450
2y03Y01Beta-1 adrenergic receptor/0.449
1jklANPDeath-associated protein kinase 12.7.11.10.448
4l9i8PRRhodopsin kinase/0.446
2ckeIQUDeath-associated protein kinase 2/0.444
4c3pACPAurora kinase A2.7.11.10.444
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
5av2KMPDeath-associated protein kinase 12.7.11.10.443
2yaaATPDeath-associated protein kinase 2/0.442
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.440