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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lboLDTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lboLDTAldose reductase1.1.1.211.000
3lqlLDTAldose reductase1.1.1.210.888
3m4h388Aldose reductase1.1.1.210.849
1z3n3NAAldose reductase1.1.1.210.726
2fz9ZSTAldose reductase1.1.1.210.712
3m64393Aldose reductase1.1.1.210.711
1z8962PAldose reductase1.1.1.210.702
4yu153NAldose reductase1.1.1.210.696
2pdxZSTAldose reductase1.1.1.210.691
2ikj393Aldose reductase1.1.1.210.686
2dv0ZSTAldose reductase1.1.1.210.680
2duxZSTAldose reductase1.1.1.210.671
3lz5LDTAldose reductase1.1.1.210.645
4gca2X9Aldose reductase1.1.1.210.644
2ikhLITAldose reductase1.1.1.210.643
1t41ID5Aldose reductase1.1.1.210.642
1t40ID5Aldose reductase1.1.1.210.641
1us0LDTAldose reductase1.1.1.210.641
2hv5ZSTAldose reductase1.1.1.210.640
3mb9ZSTAldose reductase1.1.1.210.639
2i16LDTAldose reductase1.1.1.210.638
2iki388Aldose reductase1.1.1.210.627
3lenZSTAldose reductase1.1.1.210.622
2qxwLDTAldose reductase1.1.1.210.618
2pd5ZSTAldose reductase1.1.1.210.609
3ld5LDTAldose reductase1.1.1.210.609
2pdu393Aldose reductase1.1.1.210.608
2pzn393Aldose reductase1.1.1.210.606
2pdbZSTAldose reductase1.1.1.210.604
2pdg47DAldose reductase1.1.1.210.603
2i17LDTAldose reductase1.1.1.210.601
3m0iZSTAldose reductase1.1.1.210.599
1pwlBFIAldose reductase1.1.1.210.597
3mc5393Aldose reductase1.1.1.210.597
2pdc393Aldose reductase1.1.1.210.596
2duzZSTAldose reductase1.1.1.210.593
2fz8ZSTAldose reductase1.1.1.210.593
2pdfZSTAldose reductase1.1.1.210.590
2pdh47DAldose reductase1.1.1.210.589
3t423T4Aldose reductase1.1.1.210.587
3ghuLDTAldose reductase1.1.1.210.581
2pdp393Aldose reductase1.1.1.210.578
3g5eQ74Aldose reductase1.1.1.210.577
2pdn47DAldose reductase1.1.1.210.576
2pdq47DAldose reductase1.1.1.210.576
2pevNDPAldose reductase1.1.1.210.575
2hvoZSTAldose reductase1.1.1.210.572
3ghrLDTAldose reductase1.1.1.210.568
1ieiZESAldose reductase1.1.1.210.557
2fzdTOLAldose reductase1.1.1.210.550
1frbZSTAldose reductase-related protein 2/0.542
2pdj393Aldose reductase1.1.1.210.542
3ghtLDTAldose reductase1.1.1.210.516
3ghsLDTAldose reductase1.1.1.210.513
1el3I84Aldose reductase1.1.1.210.510
1ah3TOLAldose reductase1.1.1.210.506
5liu388Aldo-keto reductase family 1 member B101.1.10.501
2pdlTOLAldose reductase1.1.1.210.500
2agtFIDAldose reductase1.1.1.210.495
2fzbTOLAldose reductase1.1.1.210.490
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
2f2kTGGAldose reductase1.1.1.210.474
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.474
2pd9FIDAldose reductase1.1.1.210.473
4wevSUZAldo-keto reductase family 1 member B101.1.10.472
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3b82NADExotoxin A2.4.2.360.467
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.466
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.462
4phlPILPhosphodiesterase/0.462
1h22E10Acetylcholinesterase3.1.1.70.461
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.460
1ekoI84Aldose reductase1.1.1.210.459
3mjrAC2Deoxycytidine kinase2.7.1.740.458
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.456
4u163C0Muscarinic acetylcholine receptor M3/0.456
4dbw511Aldo-keto reductase family 1 member C3/0.455
2pdwFIDAldose reductase1.1.1.210.454
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/0.454
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2oazI96Methionine aminopeptidase 2/0.452
2qimZEAClass 10 plant pathogenesis-related protein/0.452
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4daj0HKMuscarinic acetylcholine receptor M3/0.452
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.449
2ga2A19Methionine aminopeptidase 2/0.449
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.449
1yw7A41Methionine aminopeptidase 2/0.448
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.448
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
3u2cSUZAldose reductase1.1.1.210.448
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
2f3815MAldo-keto reductase family 1 member C3/0.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.447
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
1lnmDTXBilin-binding protein/0.446
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2inzOHPAldose reductase1.1.1.210.446
3zv7NHGAcetylcholinesterase3.1.1.70.446
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.446
1gt5BZQOdorant-binding protein/0.445
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2v0mKLNCytochrome P450 3A4/0.445
3f3y4OABile salt sulfotransferase2.8.2.140.445
4ea2RWZDehydrosqualene synthase/0.445
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.444
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
1obnASVIsopenicillin N synthase1.21.3.10.443
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4k4eK4ETankyrase-12.4.2.300.443
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.442
2pdyFIDAldose reductase1.1.1.210.442
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.441
1e66HUXAcetylcholinesterase3.1.1.70.441
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3v35NTIAldose reductase1.1.1.210.441
3uonQNBMuscarinic acetylcholine receptor M2/0.441
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.440
4ey6GNTAcetylcholinesterase3.1.1.70.440
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.440