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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l8sBFFMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3l8sBFFMitogen-activated protein kinase 14/1.000
3lfeZ84Mitogen-activated protein kinase 14/0.535
3o8tBMUMitogen-activated protein kinase 14/0.493
4eh50OMMitogen-activated protein kinase 14/0.492
3oc1BMUMitogen-activated protein kinase 14/0.481
3hv3R49Mitogen-activated protein kinase 14/0.479
2ewaSB2Mitogen-activated protein kinase 14/0.478
3gcq1BUMitogen-activated protein kinase 14/0.478
4dlj6RGMitogen-activated protein kinase 14/0.476
1ouy094Mitogen-activated protein kinase 14/0.472
1bl7SB4Mitogen-activated protein kinase 14/0.471
3gc9B45Mitogen-activated protein kinase 112.7.11.240.471
4eh60ONMitogen-activated protein kinase 14/0.465
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.462
2po7CHDFerrochelatase, mitochondrial4.99.1.10.453
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.452
3cv9VDXVitamin D3 dihydroxylase/0.451
3gwfFADCyclohexanone monooxygenase/0.450
3zsh469Mitogen-activated protein kinase 14/0.450
4lxhC1EAlpha/beta hydrolase fold/0.450
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
1bl6SB6Mitogen-activated protein kinase 14/0.447
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
1ove358Mitogen-activated protein kinase 14/0.442
1ouk084Mitogen-activated protein kinase 14/0.441
1q5dEPBEpothilone C/D epoxidase1.140.441
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1zg32HIIsoflavone 4'-O-methyltransferase/0.441
4rkdKETAminotransferase/0.440