scPDB - Distribution of Cavity Similarity values of 3l3r entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3l3r	OAG	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	1.000
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.608
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.604
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.601
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.597
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.589
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.584
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.584
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.583
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.574
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.572
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.568
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.562
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.561
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.558
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.555
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.546
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.544
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.539
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.536
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.534
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.531
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.531
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.527
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.526
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.525
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.524
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.524
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.519
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.519
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.516
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.514
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.509
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.505
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.504
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.501
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.499
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.497
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.495
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.492
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.491
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.488
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.486
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
3qly	55V	Uncharacterized protein	/	0.483
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.483
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.483
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.482
3qlz	QLZ	Uncharacterized protein	/	0.480
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.477
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.475
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.474
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.474
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.473
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.473
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.473
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.470
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.470
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.467
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.464
3qlx	QLR	Uncharacterized protein	/	0.464
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.463
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.462
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.462
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.462
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.460
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.459
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.457
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.457
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.457
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.455
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.453
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.453
3p9t	TCL	Repressor	/	0.453
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.453
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.452
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.451
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.450
3cse	N22	Uncharacterized protein	/	0.450
3eej	53R	Uncharacterized protein	/	0.450
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.450
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.449
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.449
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.448
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.448
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.447
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.447
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.446
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.446
2bxo	OPB	Serum albumin	/	0.445
3eek	53S	Uncharacterized protein	/	0.445
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.442
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.441
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.440
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.440
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.440