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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.261.000
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.561
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.559
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.538
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.497
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.494
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.483
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.482
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.479
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.479
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.478
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.475
4bgg844Activin receptor type-12.7.11.300.473
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.472
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.469
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.468
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.464
2vu3LZECyclin-dependent kinase 22.7.11.220.463
3mtfA3FActivin receptor type-12.7.11.300.461
1dayGNPCasein kinase II subunit alpha2.7.11.10.459
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.456
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.455
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.445
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.443
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
3s1h56ZCyclin-dependent kinase 22.7.11.220.442
4jboWPHAurora kinase A2.7.11.10.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.440