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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kvxFMYMitogen-activated protein kinase 102.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3kvxFMYMitogen-activated protein kinase 102.7.11.241.000
2xrwANPMitogen-activated protein kinase 82.7.11.240.576
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.560
4g1wG1WMitogen-activated protein kinase 82.7.11.240.493
4jboWPHAurora kinase A2.7.11.10.483
3cgoJNOMitogen-activated protein kinase 102.7.11.240.481
3i60E86Mitogen-activated protein kinase 12.7.11.240.477
1pmn984Mitogen-activated protein kinase 102.7.11.240.470
4e730NRMitogen-activated protein kinase 82.7.11.240.470
5e8ySTUTGF-beta receptor type-22.7.11.300.470
2o2u738Mitogen-activated protein kinase 102.7.11.240.469
3ttiKBIMitogen-activated protein kinase 102.7.11.240.467
3cgfJNFMitogen-activated protein kinase 102.7.11.240.461
4j95ACPFibroblast growth factor receptor 2/0.461
4dgnLU2Casein kinase II subunit alpha2.7.11.10.459
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.456
4jbpYPHAurora kinase A2.7.11.10.454
2p33J07Mitogen-activated protein kinase 102.7.11.240.453
4ux9ANPMitogen-activated protein kinase 82.7.11.240.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.447
2xs0ANPMitogen-activated protein kinase 82.7.11.240.446
4ocvANPAminoglycoside phosphotransferase/0.446
1jnkANPMitogen-activated protein kinase 102.7.11.240.444
3orpAGSSerine/threonine protein kinase/0.444
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.443
3eljGS7Mitogen-activated protein kinase 82.7.11.240.442
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4anmWULCasein kinase II subunit alpha2.7.11.10.441