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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3kmtSAHHistone H3K27 methylase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3kmtSAHHistone H3K27 methylase/1.000
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.505
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.488
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.473
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.466
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.456
4nvq2ODHistone-lysine N-methyltransferase EHMT2/0.454
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.453
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.453
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.449
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.443
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.441