sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kec | 3KE | Collagenase 3 | 3.4.24 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 1.000 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.621 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.588 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.584 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.574 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.573 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.569 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.569 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.566 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.564 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.550 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.549 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.546 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.546 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.544 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.543 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.540 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.530 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.530 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.530 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.524 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.524 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.524 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.523 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.523 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.522 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.520 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.520 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.519 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.519 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.515 | |
| 4h30 | 0ZD | Macrophage metalloelastase | 3.4.24.65 | 0.514 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.512 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.512 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.511 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.506 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.506 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.505 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.501 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.501 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.499 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.499 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.498 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.494 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.492 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.490 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.487 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.483 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.483 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.482 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.480 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.480 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.478 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.476 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.476 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.474 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.468 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.464 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.461 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.461 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.456 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.452 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.450 | |
| 4l4x | NDP | AmphI | / | 0.447 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.445 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.440 |